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Most studies aim to improve the hydrophobicity of materials by modifying their contact angle, thereby enhancing water stability. However, water droplets poorly adhere to the surface of hydrophobic materials, limiting their application for direct contact and detection in aqueous environments. Drawing inspiration from the sacrificial protection mechanism of butterfly wings used to evade predation and entanglement, a universal approach is successfully developed to protect water\u2010sensitive MIL\u2010MOFs from water molecule attack while preserving good hydrophilicity. Using the organic ligand 2,2\u2032\u2010bipyridine\u20105,5\u2032\u2010dicarboxylic acid (bpydc) as sacrificial protection scales, the MIL\u2010125\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    \u2010bpydc demonstrated broad pH structural stability (pH 2\u201312) and fluorescence stability increased by 10.17 time in aqueous solutions, achieving the highest performance in MILMOFs. The MIL\u2010125\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    \u2010bpydc is biocompatible enabling it to perform long\u2010term fluorescence imaging in living cells and zebrafish, further detecting hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) in the aqueous and biological systems via turn\u2010on fluorescence emission. This study offers a novel and universal sacrifice\u2010protection strategy for the design and development of the luminescent biocompatible MOFs tailored for biosensing applications.\n                  <\/jats:p>","DOI":"10.1002\/smtd.202500277","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:39:01Z","timestamp":1744623541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Water\u2010Stable MIL\u2010MOFs Developed Through a Novel Sacrifice\u2010Protection Strategy Inspired by Butterfly Wings\u2019 Scales for Long\u2010Term Turn\u2010On Fluorescence Sensing of H\n                    <sub>2<\/sub>\n                    S"],"prefix":"10.1002","volume":"9","author":[{"given":"Zhanglin","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Chemistry MOE Key Laboratory of Analysis and Detection for Food Safety and Biology Fujian Provincial Key Laboratory of 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