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The proposed method utilizes a \u201cneedle\u2010eye\u201d design, featuring a through\u2010microchannel fabricated at the needle tip. The microchannel and its surface are tuned via focused ion beam (FIB) milling and plasma treatment, enabling NPs dispersed in a resin precursor to be confined in the microchannel due to a pressure gradient upon immersion. The retained suspension is promptly polymerized in situ on the tip and shaped by FIB milling into specific geometries, including but not limited to a micropillar, lamella, and nanoneedle. Here, to demonstrate its applicability, a mixed metal oxide catalyst prepared by the needle\u2010eye approach is characterized with energy\u2010dispersive X\u2010ray spectroscopy (EDX), FIB secondary ion mass spectrometry (FIB\u2010SIMS), (scanning) transmission electron microscopy ((S)TEM), and atom probe tomography (APT). The results validate the ability of the method to achieve multimodal, combining correlative and complementary high\u2010resolution structural and chemical imaging of individuals and clustered NPs. The proposed method confines picoliter\u2010scale samples (6\u201360 pL) at a tip, eliminating lift\u2010out and microtomy while enabling comprehensive analysis via combined microscopy techniques.<\/jats:p>","DOI":"10.1002\/smtd.202500622","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T07:19:18Z","timestamp":1748243958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["On\u2010Tip Polymerization Method for Multimodal Characterization of Nanoparticles with Electron\/Ion Imaging and Atom Probe Tomography"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-8919","authenticated-orcid":false,"given":"Aristide","family":"Djoulde","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Monash University  Clayton Victoria 3800 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