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However, their diverse designs necessitate specialized analytical equipment, which complicates standardization, limits productivity, impedes universal analysis, and hinders the acquisition of reliable data. To address these issues, a 96\u2010Puddle Paper Plate (96\u2010PPP) is presented, a versatile lab\u2010on\u2010paper platform that is fully compatible with microplate readers. The 96\u2010PPP offers significant advantages in high\u2010throughput analysis, enabling both qualitative assessments using visual inspection and smartphone cameras, as well as quantitative measurements of absorbance and fluorescence. The versatility of this platform is demonstrated by its ability to detect a wide range of key analytes, including acetone, magnesium ions (Mg\n                    <jats:sup>2+<\/jats:sup>\n                    ), ascorbic acid, and ketone, which is pertinent to clinical diagnostics, metabolic research, and environmental monitoring. Additionally, 96\u2010PPP enables the study of amyloid deposition (variation within 3.5% across 480 puddles) and proteolysis in cellulose networks that resemble extracellular matrix structures, a capability not achievable with conventional 96\u2010well plates. Overall, 96\u2010PPP replicates the functionality of 96\u2010well plates and concurrently addresses the limitations of conventional \u00b5PADs, such as low productivity, versatility, and reliability. Furthermore, it provides unprecedented scalability via a stable, cellulose\u2010based sheet.\n                  <\/jats:p>","DOI":"10.1002\/smtd.202500729","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:26:52Z","timestamp":1749727612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The 96\u2010Puddle Paper Plate as a Versatile Lab\u2010on\u2010Paper Platform"],"prefix":"10.1002","volume":"9","author":[{"given":"Taeha","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Bioinformatics Korea University  Sejong 30019 South Korea"},{"name":"Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University  Sejong 30019 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeongjun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Biotechnology 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