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Yet, physical\u2010chemical differences between chemodrugs and nucleic acids often hinder the construction of feasible delivery systems with synergistic activity. Herein, a smart supramolecular polymeric scaffold is reported to co\u2010load chemodrug paclitaxel (PTX) and Bcl\u20102 small interfering RNA (siRNA), respectively via Hydrogen\u2010bonding (H\u2010bonding) association and electrostatic interaction, toward efficiently reversing drug resistance and significantly inhibiting tumor growth in a synergistic manner via GT\u2010enhanced CT. Therefore, a cationic copolymer carrier, P(OEGA\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010DMAEA)\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010P(HFA\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010TU) (e.g., PODHT), serves as a structurally distinct drug\u2010delivery platform. The hydrophobic section, P(HFA\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010TU) (poly((heptafluorobutyl acrylate)\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010acylthiourea)), incorporates pendant thiourea (TU) moieties that can selectively recognize hydrophobic PTX. Such molecular recognition and co\u2010assembly are governed by TU\/PTX double H\u2010bonding association in concert with hydrophobic interactions. Moreover, the cationic shell consisting of P(OEGA\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010DMAEA) (poly(oligo(ethylene glycol) monomethyl ether acrylate\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u20102\u2010dimethylaminoethyl acrylate)) from resulting PTX\u2010loaded micelles can steadily bind the negative siRNA via electrostatic interaction, finally to afford the targeted supramolecular micelleplexes PTX@PODHT\/siRNA. Such nanoplatform not only possesses the enhanced co\u2010loading capacity and transportation stability of distinct PTX and siRNA, but also can induce pH\u2010responsive cargos release within the tumor zone, ultimately effectively inhibiting tumor growth via synergistic CT\/GT.\n                  <\/jats:p>","DOI":"10.1002\/smtd.202500760","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:06:13Z","timestamp":1764050773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Supramolecular Micelleplex Co\u2010Delivers Bcl\u20102 siRNA and Paclitaxel for Synergistic Chemo\u2010Gene Cancer Therapy"],"prefix":"10.1002","volume":"10","author":[{"given":"Yanggui","family":"Wu","sequence":"first","affiliation":[{"name":"Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Cosme Biotechnology Co., Ltd.  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