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To amplify catalytic efficiency, structural engineering of nanozymes through hollow architectures has emerged as a pivotal strategy by maximizing active site accessibility and optimizing substrate diffusion kinetics. However, conventional synthetic routes necessitate extreme chemical conditions and complex processes, hindering the functional integration of biomolecule. Herein, a template\u2010free self\u2010assembly strategy is developed to construct hollow Au\u2010adenine coordination polymers (HAuA CPs) through ethanol\u2010induced reconstruction at ambient temperature. By optimizing HAuCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010adenine coordination chemistry, precursors formed within 8 minutes in aqueous solution, followed by ligand displacement\u2010driven structural evolution to yield hollow architectures with specific shell thickness. Density functional theory calculations reveal ethanol molecules competitively weaken Au\u2013N\/Cl bonds, enabling spontaneous hollowing. The optimized HAuA CPs exhibits 1.75\u2010fold enhanced oxidase\u2010like activity and catalase\u2010like functionality modulated by pH, compared to solid counterparts. Crucially, this mild synthesis preserved activity of encapsulated glucose oxidase, achieving 31.7\u2010fold reactive oxygen species generation. In vivo experiment prove that the system induce significant tumor growth inhibition (83.3%). This work establishes a green and universal synthesis strategy for hollow coordination nanozymes and provides mechanistic insights into structure control of coordination nanozymes for advanced catalytic therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/smtd.202500931","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T07:41:07Z","timestamp":1753083667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Hollow Nucleobase Coordinated Nanozyme for Tumor Catalytic Therapy"],"prefix":"10.1002","volume":"10","author":[{"given":"Qingyuan","family":"Wu","sequence":"first","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology  Beijing 100029 P.R. China"},{"name":"Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Tsinghua University  No. 30, Shuangqing Road, Haidian District Beijing 100084 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengjia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology  Beijing 100029 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolong","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology  Beijing 100029 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokun","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology  Beijing 100029 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical and Health Materials SINOPEC Beijing Research Institute of Chemical Industry  Beijing 100013 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Medical and Health Materials SINOPEC Beijing Research Institute of Chemical Industry  Beijing 100013 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology  Beijing 100029 P.R. 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