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Here, a monoatomic\u2010node strategy combined with solvent reduction was used to construct a rare trinuclear copper MOF featuring a planar, equilateral\u2010triangular Cu\n                    <jats:sup>I<\/jats:sup>\n                    <jats:sub>0.6<\/jats:sub>\n                    Cu\n                    <jats:sup>II<\/jats:sup>\n                    <jats:sub>2.4<\/jats:sub>\n                    core. The Cu\n                    <jats:sup>I<\/jats:sup>\n                    <jats:sub>0.6<\/jats:sub>\n                    Cu\n                    <jats:sup>II<\/jats:sup>\n                    <jats:sub>2.4<\/jats:sub>\n                    \u2013MOF nanozyme shows enzymatic activity 37.2 times than that of laccase and 13.6 times than that of a Cu\n                    <jats:sup>II<\/jats:sup>\n                    <jats:sub>3<\/jats:sub>\n                    \u2013MOF analogue, retains high chemical stability from pH 4 to 12, and lowers production cost by 16.2\u2010fold relative to natural laccase. DFT calculations attribute the superior performance to the introduction of Cu\n                    <jats:sup>+<\/jats:sup>\n                    , which yields a more favorable electronic structure, reaction energy landscape, and intermediate binding than in Cu\n                    <jats:sup>II<\/jats:sup>\n                    <jats:sub>3<\/jats:sub>\n                    \u2013MOF. Consequently, Cu\n                    <jats:sup>I<\/jats:sup>\n                    <jats:sub>0.6<\/jats:sub>\n                    Cu\n                    <jats:sup>II<\/jats:sup>\n                    <jats:sub>2.4<\/jats:sub>\n                    \u2013MOF efficiently degrades phenolic pollutants and enables colorimetric discrimination and detection of 11 phenols as a colorimetric sensor array. It also affords sensitive detection of epinephrine and dopamine, with limits of detection of 6.5 and 10\u00a0\u00b5\n                    <jats:sc>m<\/jats:sc>\n                    , respectively. Overall, this work demonstrates a laccase\u2010inspired route to high\u2010activity, low\u2010cost MOFs with strong potential for environmental remediation and biosensing.\n                  <\/jats:p>","DOI":"10.1002\/smtd.202502191","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:35:59Z","timestamp":1767677759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bio\u2010Inspired Laccase\u2010Mimicking Cu\n                    <sub>3<\/sub>\n                    \u2013MOF Nanozyme as Colorimetric Sensor Array for Rapid Degradation and Visual Sensing of Phenolic Compounds"],"prefix":"10.1002","volume":"10","author":[{"given":"Haitao","family":"Han","sequence":"first","affiliation":[{"name":"College of Medical Engineering&amp; the Key Laboratory for Medical Functional Nanomaterials Jining Medical University  Jining Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YangCui","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Medical Engineering&amp; the Key Laboratory for Medical Functional Nanomaterials Jining Medical University  Jining Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhe","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Medical College  Shenyang Liaoning P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JunHao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong P. R. 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