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Small electrochemical biosensors are appealing because they are fast, require microliter sample volumes, and can be integrated into portable devices. However, shrinking the sensor area often weakens the signal, making it difficult to detect low viral loads. We previously showed that combining redox cycling with controlled droplet evaporation can boost the signal. Yet, this method faces signal variability due to user\u2010dependent droplet placement. Here, we introduce a selective\u2010wettability, evaporation\u2010enhanced redox cycling (SW\u2010E2RC) device that passively centers and pins the droplet on the sensing area, improving both signal strength and reproducibility. The chip combines a wettable sensing zone surrounded by water\u2010repellent micropillars that guide the droplet into place and stabilize it during evaporation, concentrating redox\u2010active species over the electrodes. Using SARS\u2010CoV\u20102 and avian influenza H5N1 as model pathogens, we show that SW\u2010E2RC reduces the LOD to 9.2 \u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    copies\/mL, corresponding to a \u223c10\n                    <jats:sup>3<\/jats:sup>\n                    \u2010fold improvement in sensitivity compared with E2RC. This platform can be adapted to various capture probes and targets, enabling more sensitive and reliable point\u2010of\u2010need viral diagnostics.\n                  <\/jats:p>","DOI":"10.1002\/smtd.202502229","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:28:54Z","timestamp":1768807734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective Wettability\u2013Driven Evaporation\u2010Enhanced Redox Cycling for Robust and Ultrasensitive Detection of Viral Particles"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6121-338X","authenticated-orcid":false,"given":"Pouya","family":"Soltan Khamsi","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering The Pennsylvania State University University Park Pennsylvania USA"},{"name":"Materials Research Institute The Pennsylvania State University University Park 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