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However, current in vivo imaging techniques lack the necessary precision, sensitivity, and resolution to meet this demand. Here, we report a renal\u2010clearable, tantalum\u2010rich carbon dot (Ta\u2010rCD) contrast agent that enables high\u2010performance computed tomography (CT) imaging for noninvasive visualization and differentiation of multiple AKI subtypes. The Ta\u2010rCDs are synthesized via a simple and efficient air\u2010assisted carbonization method, featuring ultrahigh Ta content (48%), gram\u2010scale production capacity, ultrasmall hydrodynamic size (\u223c2.8\u00a0nm), excellent water solubility (&gt;500\u00a0mg mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), and strong x\u2010ray attenuation capability. Benefiting from their renal\u2010clearable nature, Ta\u2010rCDs avoid long\u2010term retention in vivo while enabling effective renal imaging. Notably, Ta\u2010rCDs enable high\u2010resolution anatomical and functional CT imaging across pre\u2010renal, renal, and post\u2010renal AKI models, facilitating precise detection of renal dysfunction beyond the reach of conventional biochemical markers. Furthermore, this approach allows accurate differentiation of AKI subtypes based on their distinct CT imaging features. In vitro and in vivo studies confirm their favorable biocompatibility. Our work provides a new paradigm for the development of sensitive and high\u2010resolution CT imaging contrast agents and offers a promising method for the accurate diagnosis of kidney diseases.\n                  <\/jats:p>","DOI":"10.1002\/smtd.70664","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:46:07Z","timestamp":1776843967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Renal\u2010Clearable Tantalum Contrast Agent Enables Precise CT Diagnosis and Subtyping of Acute Kidney Injury"],"prefix":"10.1002","volume":"10","author":[{"given":"Gang","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Radiology National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer Institute and Hospital Tianjin 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