{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:10:28Z","timestamp":1788952228180,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008656","name":"Iketani Science and Technology Foundation","doi-asserted-by":"publisher","award":["0361252\u2010A"],"award-info":[{"award-number":["0361252\u2010A"]}],"id":[{"id":"10.13039\/501100008656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JPMXP1224NM5259"],"award-info":[{"award-number":["JPMXP1224NM5259"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JPMXP1225NM5235"],"award-info":[{"award-number":["JPMXP1225NM5235"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small Methods"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The detection of single particles or molecules represents a critical milestone in the development of biosensing technologies. Optical sensors based on quasi\u2010bound states in the continuum (qBICs) have primarily focused on detecting global refractive index changes, whereas detection of local refractive index perturbations, such as the binding of a nanometer\u2010sized molecule on a surface, remains elusive because of limited quality (\n                    <jats:italic>Q<\/jats:italic>\n                    ) factors and relatively large mode volumes. Here, we demonstrate low\u2010contrast BIC metasurfaces that can perform sensing with a virus\u2010sized single\u2010nanoparticle resolution. The qBIC resonance operating at the critical coupling condition exhibits an experimental\n                    <jats:italic>Q<\/jats:italic>\n                    factor of 4.5 \u00d7 10\n                    <jats:sup>4<\/jats:sup>\n                    in heavy water. The strong interactions between the localized electric field and polystyrene nanoparticles with a diameter of 100\u00a0nm enable the experimental observation of step\u2010like resonance wavelength shifts, serving as signatures of individual particle binding events. Furthermore, binding\u2010induced modifications to the qBIC resonance alter the optical confinement and asymmetry factor, inducing changes not only in the resonance wavelength but also in the linewidth and amplitude with single\u2010particle sensitivity. Combined with position\u2010insensitive response and free\u2010space accessible features, low\u2010contrast BIC metasurfaces provide a user\u2010friendly platform for next\u2010generation single\u2010nanoparticle sensing integrated with microfluidic systems.\n                  <\/jats:p>","DOI":"10.1002\/smtd.70931","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:57:32Z","timestamp":1785905852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010Nanoparticle Detection Using Quasi\u2010Bound States in the Continuum Supported by Silicon Metasurfaces"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-2135","authenticated-orcid":false,"given":"Keisuke","family":"Watanabe","sequence":"first","affiliation":[{"name":"International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS)  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0545-0348","authenticated-orcid":false,"given":"Samuel","family":"Crowther","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy Living Systems Institute University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-6940","authenticated-orcid":false,"given":"Masanobu","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Research Center for Electronic and Optical Materials National Institute for Materials Science (NIMS)  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-4671","authenticated-orcid":false,"given":"Frank","family":"Vollmer","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy Living Systems Institute University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6746-2686","authenticated-orcid":false,"given":"Tadaaki","family":"Nagao","sequence":"additional","affiliation":[{"name":"International Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS)  Tsukuba Ibaraki Japan"},{"name":"Department of Condensed Matter Physics Graduate School of Science Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adom.202301912"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01562-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c03585"},{"key":"e_1_2_8_5_1","first-page":"4100","article-title":"Superchiral Light Emerging From Bound States in the Continuum in Metasurfaces of Si Nanorod Dimers","volume":"11","author":"Pura J. 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