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Herein, we address this by developing a dual\u2010mode optoelectronic sensing platform. A self\u2010designed Cys fluorescent probe was integrated into a plasmonic nanopore via a site\u2010selective functionalization strategy. This platform synergistically combines plasmon\u2010enhanced fluorescence with nanopore\u2010based electrochemical detection, providing complementary optical and electrical signals that enable high spatio\u2010temporal resolution for accurate analyte quantification. The confined geometry of the nanopore enhances sensitivity by concentrating electromagnetic fields into sub\u2010diffraction volumes and restricting molecular motion within the nanospace. The developed Cys sensor achieves high sensitivity, along with excellent selectivity and strong anti\u2010interference capability, as validated through an \u201cAND\u201d logic gate operation. Importantly, the practical utility of the sensor is demonstrated by successful quantification of exogenous Cys in living MDA\u2010MB\u2010231 cells, confirming its capability for in situ cellular analysis. Furthermore, this versatile plasmonic nanopore platform can be readily adapted for the detection of various small molecules by simply substituting the probe molecule, offering a simple, stable, and generalizable sensing approach in small molecules detection.<\/jats:p>","DOI":"10.1002\/smtd.70990","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:39:00Z","timestamp":1788179940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Plasmonic Nanopore Sensor for Dual\u2010Gating Optoelectronic Detection of Cysteine"],"prefix":"10.1002","volume":"10","author":[{"given":"Di","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis &amp; Instrumentation College of Chemistry and Chemical Engineering Xiamen University  Xiamen P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis &amp; Instrumentation College of Chemistry and Chemical Engineering Xiamen University  Xiamen P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-1553","authenticated-orcid":false,"given":"Shuo\u2010Hui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis &amp; Instrumentation College of Chemistry and Chemical Engineering Xiamen University  Xiamen P. R. China"},{"name":"Department of Electronic Science Xiamen University  Xiamen P. R. 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