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However, conventional NMR measurements are inherently sequential, which limits experimental throughput. We recently demonstrated that\n                    <jats:sup>19<\/jats:sup>\n                    F MR imaging (MRI) enables spatial parallelization of such measurements. In this study, we leverage the reporter assay format, where the transverse relaxation () of a fluorinated reporter ligand is monitored in the presence of potential competitors. Using \u2010weighted MR images, up to 61 miniaturized samples can be resolved simultaneously. The screening assay operates at microliter\u2010scale volumes in a custom miniaturized honeycomb sample holder, providing a readily accessible and scalable quantitative binding assay. To further accelerate data acquisition, we developed optimized imaging protocols based on compressed sensing (CS), enabling substantial reductions in measurement time without compromising quantitative accuracy. This approach allows parallel screening of 55 potential ligands and efficient determination of relative binding affinities through simultaneous dose\u2010response experiments. We demonstrate the method on the model protein trypsin and the antibiotic target PPAT, characterizing several ligands with distinct binding properties. This study highlights the potential of MRI to enhance throughput and efficiency in early\u2010stage drug discovery\u00a0markedly.\n                  <\/jats:p>","DOI":"10.1002\/smtd.71004","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:27:51Z","timestamp":1788776871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Parallelized 61\u2010Sample Inhibition Screening Accelerated by\n                    <sup>19<\/sup>\n                    F\u2010MRI Compressed Sensing"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6680-6117","authenticated-orcid":false,"given":"Dilara","family":"Faderl","sequence":"first","affiliation":[{"name":"Institute of Microstructure Technology Karlsruhe Institute of Technology Eggenstein\u2010Leopoldshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-495X","authenticated-orcid":false,"given":"Alvar D.","family":"Gossert","sequence":"additional","affiliation":[{"name":"Department of Biology ETH Zurich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-7295","authenticated-orcid":false,"given":"Jan G.","family":"Korvink","sequence":"additional","affiliation":[{"name":"Institute of Microstructure Technology Karlsruhe Institute of Technology Eggenstein\u2010Leopoldshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-4845","authenticated-orcid":false,"given":"Neil","family":"MacKinnon","sequence":"additional","affiliation":[{"name":"Institute of Microstructure Technology Karlsruhe Institute of Technology Eggenstein\u2010Leopoldshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2010.01127.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2006.06.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206778743600"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099\u20101352(199901\/02)12:1<3::AID\u2010JMR441>3.0.CO;2\u20106"},{"key":"e_1_2_8_6_1","first-page":"79","volume-title":"Methods in Cell Biology","author":"Freyer M. 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