{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:46:10Z","timestamp":1792583170240,"version":"4.5.0"},"reference-count":181,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small Methods"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Synthetic cells are emerging as promising platforms that combine cell\u2010free biomolecule synthesis with the programmability of bottom\u2010up engineered compartments. By decoupling biomolecule production from cellular growth and evolutionary constraints, synthetic cells enable the controlled generation of proteins, nucleic acids, peptides, and signaling molecules within defined artificial environments. However, many envisioned biomedical applications require precise regulation over biomolecule synthesis, activation, transport, release, and communication. In this Review, we examine how light can provide spatiotemporal control over synthetic cell functions relevant to future therapeutic applications. We compare external control modalities and review optical strategies that regulate synthetic cell functions across multiple functional layers, including biomolecule synthesis, activation, transport and release, communication, and systems\u2010level integration. Particular emphasis is placed on integrating optical control with cell\u2010free expression systems, RNA\u2010based regulatory platforms, membrane engineering, and emerging synthetic cell architectures. We further discuss challenges associated with system integration, biomolecule complexity, energy management, light delivery, and translation. By classifying optical methodologies according to the functional layers they regulate, we provide a methodology\u2010centered framework for comparing and integrating optical\u2010control strategies toward increasingly sophisticated light\u2010responsive synthetic cell platforms for future therapeutic applications.<\/jats:p>","DOI":"10.1002\/smtd.71136","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:27:26Z","timestamp":1792582046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optical Control of Therapeutic Synthetic Cells: Controlling Biomolecule Synthesis, Activation, and Communication"],"prefix":"10.1002","author":[{"given":"Gia Bao Leon","family":"Hoang","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry and Chemical Biology and Institute of Biochemistry Goethe\u2010Universit\u00e4t Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4465-8343","authenticated-orcid":false,"given":"Taniya","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Chemical Biology and Institute of Biochemistry Goethe\u2010Universit\u00e4t Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201802288"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1mh01431e"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6305"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00114\u2010005\u20100056\u2010z"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701163"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2511"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03300"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202202436"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2020.08.002"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001744\u20109"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2023.12.008"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121522"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304654"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010024\u201001673\u20107"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400353"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1685"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.4174230"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00116"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010019\u20100186\u20103"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010021\u201000046\u2010x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043398\u20106"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.1c00472"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00518"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202100776"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01238"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02350"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004\u2010023\u201000860\u20102"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201018673\u20105"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001823\u2010x"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205266"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202210886"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09908"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c01600"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010023\u201001374\u20107"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029871\u20108"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja109137s"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10447"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat5005"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5cc00826c"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201072328\u20105"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201069605\u20108"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202110855"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010025\u201001909\u20106"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2307772120"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2207525119"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00079"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.804717"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702208114"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj4047"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202514980"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201915303"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003469\u20105"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202400037"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010025\u201001879\u20103"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16190"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9cc02734c"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.054494"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903500116"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.slast.2023.06.004"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201031898\u2010w"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201051620\u20102"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.19662"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30332\u20102"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1261821"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13550"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.0c00205"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010017\u20102317\u20104"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/86684"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41928\u2010023\u201001013\u2010y"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1785\u201018.2018"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600521"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023025\u2010y"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2015685118"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2020.1798514"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730500158360"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00893"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2020.1779357"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4364"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.72"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010022\u201001085\u20105"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003560\u2010x"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055658\u20100"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010020\u201000585\u2010y"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219665110"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300670"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010025\u201000366\u20107"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.9b00204"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600163113"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.09.012"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231041"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7cc03455e"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.256230"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018181445"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004529\u20106"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00015.2019"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b03411"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010023\u201000850\u20107"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016249\u2010x"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b10081"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneng.2014.00016"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010022\u201000873\u20107"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010020\u20100518\u20109"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378\u2010022\u201000451\u20106"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.967491"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae678"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010022\u201000136\u20104"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010021\u201000829\u20103"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417910112"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300179f"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101188\u20101"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010025\u201000783\u20107"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1524"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9cc04768a"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200461779"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600056"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300177k"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038993\u20106"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202009890"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300663"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2644"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08446"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth975"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2006.180"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr09131a"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202514041"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb4920"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7ra03742b"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.2c00392"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038965\u2010w"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.013"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2016.1039"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.12.107"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005110\u2010x"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9168"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.082"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001726\u2010x"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010021\u201000436\u20107"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218507"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201000904\u20104"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010023\u201001016\u2010x"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja4051026"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201000041"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.002"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2023.2237719"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010019\u20100346\u2010y"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010021\u201000162\u2010z"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012170118"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009147\u20104"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz6802"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.201217011"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.107"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042434\u20109"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010025\u201000318\u20101"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001152\u2010x"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400539"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1109979"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201700147"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201027974\u2010w"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043805\u2010y"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202201486"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010021\u201000326\u2010w"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn901374b"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn967"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c02229"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202527008"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12491"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201066621\u2010y"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202400401"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029272\u2010x"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201603281"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010022\u201001351\u2010w"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201806445"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046732\u20108"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/synbio\/ysy011"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7ib00138j"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7341"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053783\u20104"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade5853"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3864"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202206474"}],"container-title":["Small Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smtd.71136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smtd.71136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smtd.71136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:27:30Z","timestamp":1792582050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smtd.71136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":181,"alternative-id":["10.1002\/smtd.71136"],"URL":"https:\/\/doi.org\/10.1002\/smtd.71136","archive":["Portico"],"relation":{},"ISSN":["2366-9608","2366-9608"],"issn-type":[{"value":"2366-9608","type":"print"},{"value":"2366-9608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"assertion":[{"value":"2026-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71136"}}