{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:59:15Z","timestamp":1773867555464,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81360081"],"award-info":[{"award-number":["81360081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsnz.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal Society of New Zealand"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Autophagy plays a dual role in colon cancer, but its mechanisms in tumor\u2010stroma interactions are unclear.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Using TCGA\u2010COAD and GSE161277 datasets, we identified autophagy\u2010related prognostic genes via bioinformatics and machine learning. RCCD1's role was further investigated using single\u2010cell RNA\u2010seq and functional coculture assays (fibroblasts\/HCT116 cells), validated in clinical samples.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    RCCD1 was upregulated in colon cancer and cancer\u2010associated fibroblasts (CAFs), correlating with poor prognosis. In CAFs, RCCD1 activated AMPK\/mTOR\/ULK1 signaling, enhancing autophagy and driving WNT5A secretion. This activated the Wnt\/CaMKII\/ERK pathway in tumor cells, promoting EMT, proliferation, and invasion. These effects were reversed by autophagy inhibition or WNT5A neutralization.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The RCCD1\u2010autophagy\u2010WNT5A axis is a critical mediator of protumorigenic CAF\u2010tumor cell crosstalk, representing a novel therapeutic target for colon cancer.\n                  <\/jats:p>","DOI":"10.1002\/snz2.70013","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T18:20:15Z","timestamp":1768760415000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RCC1 Domain\u2010Containing Protein 1 Promotes Colon Cancer Malignant Progression by Activating Autophagy\u2010Dependent WNT5A Secretion in Cancer\u2010Associated Fibroblasts"],"prefix":"10.1002","volume":"56","author":[{"given":"Chao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"},{"name":"Departments of Gastrointestinal, Hernia and Enterofistula Surgery The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Gastrointestinal, Hernia and Enterofistula Surgery The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Gynecology The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuntian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66559-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2018\/e814s"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0398-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39762-1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111349"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338231178403"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.0213"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2022.05.006"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155429"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58748-9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0694"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.06.062"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i30.6876"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2023.2180196"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2019.106338"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.04.011"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjr\/tqae061"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000003263"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.050"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0292-y"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.95122"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3136508"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02877-2"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.144323"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1542"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S289819"},{"issue":"1","key":"e_1_2_12_28_1","first-page":"33","article-title":"Sesamin Induces Autophagy in Colon Cancer Cells by Reducing Tyrosine Phosphorylation of EphA1 and EphB2","volume":"39","author":"Tanabe H.","year":"2011","journal-title":"International Journal of Oncology"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41618-7"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.48095\/ccrvch202597"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5018-x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.04.021"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1113-9"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-020-03535-9"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-024-09941-9"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2022.2088247"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118745"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.167"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.62347\/BCZW1355"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310944"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520750"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106757"}],"container-title":["Journal of the Royal Society of New Zealand"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rsnz.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/snz2.70013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rsnz.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/snz2.70013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rsnz.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/snz2.70013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:48:53Z","timestamp":1773841733000},"score":1,"resource":{"primary":{"URL":"https:\/\/rsnz.onlinelibrary.wiley.com\/doi\/10.1002\/snz2.70013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,18]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/snz2.70013"],"URL":"https:\/\/doi.org\/10.1002\/snz2.70013","archive":["Portico"],"relation":{},"ISSN":["0303-6758","1175-8899"],"issn-type":[{"value":"0303-6758","type":"print"},{"value":"1175-8899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,18]]},"assertion":[{"value":"2025-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70013"}}