{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:11:07Z","timestamp":1789488667816,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["rsnz.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal Society of New Zealand"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Antifungal resistance in tropical mycoses is an increasingly important component of the global antimicrobial resistance crisis, particularly in endemic regions where diagnostic capacity, therapeutic options, and surveillance systems are limited. This review synthesizes clinical, environmental, and genomic evidence on resistance in major endemic and tropical fungal pathogens, including\n                    <jats:italic>Histoplasma capsulatum<\/jats:italic>\n                    , the\n                    <jats:italic>Sporothrix schenckii<\/jats:italic>\n                    complex,\n                    <jats:italic>Talaromyces marneffei<\/jats:italic>\n                    , the\n                    <jats:italic>Paracoccidioides brasiliensis<\/jats:italic>\n                    complex, and tropical\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    isolates. Reported mechanisms include target alteration involving ERG11\/CYP51A and FKS1, overexpression of efflux transporters, altered ergosterol biosynthesis, stress response pathways, and biofilm\u2010associated tolerance. Environmental and agricultural selection pressures, especially azole fungicide exposure, may promote the emergence of resistant strains before human infection occurs. The revised synthesis treats prevalence estimates as descriptive aggregations rather than a formal meta\u2010analysis because included studies used heterogeneous antifungal susceptibility testing methods, breakpoints, and reporting formats. The evidence supports integrated surveillance that links clinical isolates, environmental sampling, antifungal stewardship, and genomic monitoring. Whole\u2010genome sequencing and targeted molecular assays can shorten time to resistance detection, but genotype\u2013phenotype discordance and incomplete resistance databases require cautious interpretation. Strengthening laboratory networks, improving access to validated diagnostics, and developing region\u2010specific treatment guidance are essential to limit the clinical impact of antifungal resistance in endemic tropical settings.\n                  <\/jats:p>","DOI":"10.1002\/snz2.70074","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:31:10Z","timestamp":1786408270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging Antifungal Resistance in Tropical Mycoses: A Genomic and Clinical Perspective From Endemic Zones"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-1921","authenticated-orcid":false,"given":"Meral","family":"Miraloglu","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology Medical Faculty Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1134755"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45631"},{"key":"e_1_2_12_4_1","first-page":"935","article-title":"A Proposal for Antifungal Epidemiological Cut\u2010Off Values Against Histoplasma capsulatum Var. Capsulatum Isolates From HIV\u2010Infected Patients","volume":"56","author":"Brilhante R. S. 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