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We consider two compositions, ferrite and cobalt ferrite, synthesized under conditions that create aggregated multi\u2010core nanoparticles, called nanoflowers. Each nanoflower has an ionic surfactant or dextran to provide colloid stability in water. The composition, but not the coating, greatly impacts the heating output and the magnetic particle imaging tracer quality (with cobalt ferrite significantly reduced compared to ferrite). The cobalt ferrite nanoflowers have a core\/shell structure with a reduced magnetization, which limits the effective magnetic anisotropy of the individual cobalt ferrite nanoflowers as well as the magnetic interactions among the nanoflowers. Both limitations significantly reduce the overall increase in the magnetic anisotropy with increasing magnetic field and consequently the nanoflowers\u2019 efficacy for heating and imaging. Despite this, the formation of denser\u2010packed clusters and chains with external magnetic field in the ionic surfactant\u2010cobalt ferrite nanoflowers overcomes some of the shell's detrimental effects, resulting in better heating and imaging properties compared to the dextran\u2010cobalt ferrite. In short, the magnetic anisotropy dominates over physical and magnetic structure in the performance of the studied nanoflowers for heating and imaging applications.<\/jats:p>","DOI":"10.1002\/sstr.202400410","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T17:00:10Z","timestamp":1727715610000},"source":"Crossref","is-referenced-by-count":10,"title":["Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers"],"prefix":"10.1002","volume":"6","author":[{"given":"Julie","family":"Borchers","sequence":"first","affiliation":[{"name":"NIST Center for Neutron Research National Institute of Standards and Technology  Gaithersburg MD 20899\u20106102 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Krycka","sequence":"additional","affiliation":[{"name":"NIST Center for Neutron Research National Institute of Standards and Technology  Gaithersburg MD 20899\u20106102 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Bosch\u2010Santos","sequence":"additional","affiliation":[{"name":"Material Measurement Laboratory National Institute of Standards and Technology  Gaithersburg MD 20899\u20108552 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"de Lima Correa","sequence":"additional","affiliation":[{"name":"Material Measurement Laboratory National Institute of Standards and Technology  Gaithersburg MD 20899\u20108552 USA"},{"name":"Theiss Research  La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirudh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine  Baltimore MD 21231 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden","family":"Carlton","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine  Baltimore MD 21231 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanliu","family":"Dang","sequence":"additional","affiliation":[{"name":"Material Measurement Laboratory National Institute of Standards and Technology  Gaithersburg MD 20899\u20108552 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Donahue","sequence":"additional","affiliation":[{"name":"Information Technology Laboratory National Institute of Standards and Technology  Gaithersburg MD 20899 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Gr\u00fcttner","sequence":"additional","affiliation":[{"name":"micromod Partikeltechnologie, GmbH  18057 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ivkov","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine  Baltimore MD 21231 USA"},{"name":"Department of Oncology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine  Baltimore MD 21231 USA"},{"name":"Department of Mechanical Engineering Whiting School of Engineering Johns Hopkins University  Baltimore MD 21218\u20102681 USA"},{"name":"Department of Materials Science and Engineering Whiting School of Engineering Johns Hopkins University  Baltimore MD 21218\u20102681 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-9237","authenticated-orcid":false,"given":"Cindi L.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Material Measurement Laboratory National Institute of Standards and Technology  Gaithersburg MD 20899\u20108552 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmats.2019.00179"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910030218"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.924"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1471"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1779"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2018.1430867"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.06.025"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2011.03.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11030082"},{"key":"e_1_2_10_11_1","first-page":"A93","volume":"15","author":"Danielson B. 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