{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:53:46Z","timestamp":1771509226340,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":7169,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Surgical Oncology"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human <jats:italic>myc<\/jats:italic> gene is homologous to the v\u2010<jats:italic>myc<\/jats:italic> gene, which was discovered in the avian oncogenic retrovirus MC29. Abnormally high expression of the cellular oncogenes is suspected to be involved in nonviral carcinogenesis. This article reviews the evidence that elevated expression of the human <jats:italic>myc<\/jats:italic> gene is involved in sporadic colon carcinoma and familial polyposis coli. The abundance of <jats:italic>myc<\/jats:italic> RNA and protein is frequently higher in colorectal cancer than in normal mucosa. The mechanism of this altered expression is obscure because the structure and quantity of <jats:italic>myc<\/jats:italic> DNA are very rarely disturbed. The COL0320 cell line is discussed as one unusual example of <jats:italic>myc<\/jats:italic> DNA rearrangement and amplification. There is a correlation between tumor\u2010specific elevated <jats:italic>myc<\/jats:italic> RNA level and location in the bowel; tumors distal to the transverse colon are more likely to have elevated <jats:italic>myc<\/jats:italic> expression. The site distribution of unselected colorectal malignancies with an elevated <jats:italic>myc<\/jats:italic> RNA level is similar to the site distribution of familial polyposis coli tumors. With this observation it is suggested that elevated <jats:italic>myc<\/jats:italic> RNA may be a marker of a distinct type of colorectal cancer that involves the same genetic events as precede familial polyposis coli cancer.<\/jats:p>","DOI":"10.1002\/ssu.2980030305","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T06:55:19Z","timestamp":1172127319000},"page":"152-158","source":"Crossref","is-referenced-by-count":19,"title":["The role of the oncogene c\u2010<i>myc<\/i> in sporadic large bowel cancer and familial polyposis coli"],"prefix":"10.1002","volume":"3","author":[{"given":"Paul C.","family":"Rothberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.18.120184.003005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80098-2"},{"key":"e_1_2_1_4_2","first-page":"269","article-title":"Avian leukemia viruses: Interaction with their target cells in vivo and in vitro.","volume":"516","author":"Graf T","year":"1978","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7837"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.7.1982"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.4.6.1096"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.8.1969"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1986.1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6538699"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4834"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3941898"},{"key":"e_1_2_1_13_2","unstructured":"KodaT MatsushimaS SasakiA DanjoY KakinumaM: C\u2010mycgene amplification in primary stomach cancer.Jpn J Cancer Res76551\u2013554 1985."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.2.414"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/306194a0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711490107"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(86)90086-X"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.6.1707"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90092-2"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90217-4"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/310697a0"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4221"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81802-8_3"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90012-6"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/310655a0"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.12.3345"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/318533a0"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1983.tb01749.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90534-2"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.4.11.2486"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.12.3610"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.3.942"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90030-3"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/312280a0"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2425428"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(81)90281-5"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(85)90071-7"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7842"},{"key":"e_1_2_1_39_2","first-page":"4914","article-title":"Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions","volume":"39","author":"Quinn LA","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197803000-00004"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.7.2752"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327240"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.24.7742"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1985.237"},{"key":"e_1_2_1_45_2","first-page":"241","volume-title":"Genetics in Clinical Oncology","author":"Anderson DE","year":"1985"},{"key":"e_1_2_1_46_2","volume-title":"Familial Polyposis Coli","author":"Bussey HJR","year":"1975"},{"key":"e_1_2_1_47_2","first-page":"109","volume-title":"Colorectal Cancer: Prevention, Epidemiology and Screening","author":"Anderson DE","year":"1980"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02586685"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/66.6.1037"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357908309042421"}],"container-title":["Seminars in Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fssu.2980030305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ssu.2980030305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T18:56:59Z","timestamp":1697914619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ssu.2980030305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/ssu.2980030305"],"URL":"https:\/\/doi.org\/10.1002\/ssu.2980030305","archive":["Portico"],"relation":{},"ISSN":["8756-0437","1098-2388"],"issn-type":[{"value":"8756-0437","type":"print"},{"value":"1098-2388","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}