{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:43:02Z","timestamp":1786714982952,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":6804,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Surgical Oncology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Five hundred and sixty\u2010five patients with soft\u2010tissue sarcoma were admitted to Memorial Sloan\u2010Kettering Cancer Center from July 1, 1982 to July 1, 1985. Clinical and pathologic factors were analyzed to identify initial characteristics and to determine factors associated with prognosis and the development of metastasis. In decreasing order of frequency, the most common sites of primary tumor were the extremity (51.1%), retroperito\u2010neum\/viscera (28.8%), trunk (15.9%), head and neck (3.7%) and breast (0.4%). The most common histologie types were liposarcoma (21.4%), malignant fibrous histiocytoma (20.2%), leiomyosarcoma (20.0%), fibrosarcoma (11.0%), and tendosynovial sarcoma (9.6%). One hundred and twenty\u2010eight patients (22.7%) had metastases in a median follow\u2010up period of 19 months. Metastasis was more common in patients with retroperito\u2010neal and visceral sarcomas than in patients with extremity sarcomas. Patients with leiomyosarcomas were more likely to develop metastases than those with other histologie types. Fibrosarcoma and liposarcomas were the least likely to develop metastases in this time frame. Tumors greater than 5 cm in diameter occurred more frequently in patients with metastases. Actuarial survival was related to the site of primary tumor and the histologie type and grade of malignancy. Multivariate analysis indicated that patients with low\u2010grade sarcomas, extremity sarcomas, and fibrosarcomas and patients without metastatic disease demonstrated significantly improved survival. In patients with metastases, disease\u2010free interval (&lt; 365 or &gt;365 days) was significantly related to overall survival. Thus the development of metastatic disease and prognosis in patients with soft\u2010tissue sarcoma is significantly associated with specific clinical and pathologic factors, including site of primary tumor, histologie type, histologie grade, and disease\u2010free interval.<\/jats:p>","DOI":"10.1002\/ssu.2980040105","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T06:25:58Z","timestamp":1172125558000},"page":"13-19","source":"Crossref","is-referenced-by-count":68,"title":["Soft\u2010tissue sarcoma: Initial characteristics and prognostic factors in patients with and without metastatic disease"],"prefix":"10.1002","volume":"4","author":[{"given":"Michael H.","family":"Torosian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mdclaudia","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Godbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven I.","family":"Hajdu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray F.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"16","volume":"36","author":"Estimated new cancer cases by sex for all sites\u2014US","year":"1986","journal-title":"CA"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196807000-00005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400120075013"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.4.601"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860701)58:1<190::AID-CNCR2820580133>3.0.CO;2-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)63771-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0022-5223(19)37420-3","article-title":"Analysis of prognostic factors in patients undergoing resection of pulmonary metastases from soft tissue sarcoma","volume":"87","author":"Putnam JB","year":"1984","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_9_2","first-page":"231","article-title":"Early lymphatic spread of osteogenic and soft tissue sarcomas","volume":"84","author":"Weingrad DW","year":"1978","journal-title":"Surgery"},{"key":"e_1_2_1_10_2","first-page":"423","article-title":"Non\u2010parametric estimation from incomplete observations","volume":"8","author":"Kaplan E","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc (Series B, Methodological)"},{"key":"e_1_2_1_12_2","volume-title":"Differential Diagnosis of Soft Tissue and Bone Tumors","author":"Hajdu SI","year":"1986"},{"key":"e_1_2_1_13_2","first-page":"1244","volume-title":"Principles and Practice of Oncology","author":"Rosenberg SA","year":"1985"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197911)44:5<1908::AID-CNCR2820440553>3.0.CO;2-2"}],"container-title":["Seminars in Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fssu.2980040105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ssu.2980040105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:46:35Z","timestamp":1736815595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ssu.2980040105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/ssu.2980040105"],"URL":"https:\/\/doi.org\/10.1002\/ssu.2980040105","archive":["Portico"],"relation":{},"ISSN":["8756-0437","1098-2388"],"issn-type":[{"value":"8756-0437","type":"print"},{"value":"1098-2388","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}