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About 25% of women have well\u2010developed hyperplastic changes and have a risk elevation, controlled for age, of 1.5\u20132 times that of the general population. Less than 5% of women have atypical hyperplasia demonstrating some histologic features of carcinoma in situ, which indicates a risk elevation of 4\u20135 times. This is about one half the risk associated with microscopic carcinoma in situ. Therapeutic implications of these premalignant lesions rest predominantly in their indication for the heightened intensity of subsequent breast cancer surveillance and screening.<\/jats:p>","DOI":"10.1002\/ssu.2980040403","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T06:02:15Z","timestamp":1172124135000},"page":"213-217","source":"Crossref","is-referenced-by-count":17,"title":["Histopathologic risk factors for breast cancer in women with benign breast disease"],"prefix":"10.1002","volume":"4","author":[{"given":"David L.","family":"Page","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William 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