{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:07:27Z","timestamp":1788516447884,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:00:00Z","timestamp":1508457600000},"content-version":"vor","delay-in-days":292,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stat"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The self\u2010controlled case series (SCCS) method is useful for estimating the relative incidence (RI) of acute events, such as adverse events during a specified risk period following an exposure (e.g. six\u2010week period after vaccinations or 30\u2010day period after infection\u2010related hospitalizations). In practice, the \u201coptimal\u201d risk period is unknown and must be specified. To date, two approaches are available to guide the specification of the risk period. Both methods do not fully utilize the nature of the bias due to misspecification, which to date has not been characterized. Thus, we elucidate the bias of SCCS estimate of the RI when the risk period is misspecified. We then propose a novel method that more effectively estimates the optimal risk period and the associated RI of adverse events. The new method incorporates information on the functional form of the bias. Efficacy of the proposed approach is illustrated with substantial reduction in bias and variance in simulation studies. The proposed method is illustrated with two SCCS studies to determine the (1) risk of idiopathic thrombocytopenic purpura after measles\u2013mumps\u2013rubella vaccination in children and (2) risk of cardiovascular events after infection\u2010related hospitalizations in older patients on dialysis. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/sta4.166","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T05:18:36Z","timestamp":1508476716000},"page":"373-389","source":"Crossref","is-referenced-by-count":5,"title":["Bias and estimation under misspecification of the risk period in self\u2010controlled case series studies"],"prefix":"10.1002","volume":"6","author":[{"given":"Luis Fernando","family":"Campos","sequence":"first","affiliation":[{"name":"Department of Statistics Harvard University  Cambridge 02138 MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damla","family":"\u015eent\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of California  Los Angeles 90095 CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Science University of California Irvine  Irvine 92617 CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-8239","authenticated-orcid":false,"given":"Danh V.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California Irvine  Orange 92868 CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.01790.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10151110"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533328"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008695"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116479"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.3.227"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2012.695648"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12033"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1111"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2302"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5733"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4125"}],"container-title":["Stat"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsta4.166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sta4.166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:30:11Z","timestamp":1695641411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sta4.166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/sta4.166"],"URL":"https:\/\/doi.org\/10.1002\/sta4.166","archive":["Portico"],"relation":{},"ISSN":["2049-1573","2049-1573"],"issn-type":[{"value":"2049-1573","type":"print"},{"value":"2049-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}