{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:14:35Z","timestamp":1791447275947,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":140,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL080670"],"award-info":[{"award-number":["R01 HL080670"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL141286"],"award-info":[{"award-number":["R01 HL141286"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stat"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>In longitudinal studies in which a medical device is used to monitor outcome repeatedly and frequently on the same patients over a prespecified duration of time, two clustering goals can arise. One goal is to assess the degree of heterogeneity among patient profiles. A second yet equally important goal unique to such studies is to determine frequency and duration of monitoring sufficient to identify longitudinal changes. Considering these goals jointly would identify clusters of patients who share similar patterns over time and characterize temporal stability within each cluster. We use a biclustering approach, allowing simultaneous clustering of observations at both patient and time levels and using a nonparametric hierarchical Bayesian model. Because clustering units at the time level (i.e., time points) are ordered and hence unexchangeable, we utilize a multivariate Dirichlet process mixture model by specifying a Dirichlet process prior at the patient level whose base measure employs change points at the time level to achieve the desired joint clustering. We consider structured covariance between consecutive time points and assess model performance through simulation studies. We apply the model to data on 24\u2010hr ambulatory blood pressure monitoring and examine the relationship between diastolic blood pressure and pediatric obstructive sleep apnoea.<\/jats:p>","DOI":"10.1002\/sta4.279","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T03:28:05Z","timestamp":1584329285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biclustering of medical monitoring data using a nonparametric hierarchical Bayesian model"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-5346","authenticated-orcid":false,"given":"Yan","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Environmental and Public Health Sciences University of Cincinnati  Cincinnati 45267 OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7093-8078","authenticated-orcid":false,"given":"Siva","family":"Sivaganesan","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences University of Cincinnati  Cincinnati 45221 OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center  Cincinnati 45229 OH USA"},{"name":"Department of Pediatrics University of Cincinnati  Cincinnati 45267 OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raouf S.","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati  Cincinnati 45267 OH USA"},{"name":"Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati 45229 OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0705-715X","authenticated-orcid":false,"given":"Rhonda D.","family":"Szczesniak","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center  Cincinnati 45229 OH USA"},{"name":"Department of Pediatrics University of Cincinnati  Cincinnati 45267 OH USA"},{"name":"Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati 45229 OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.099762"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176342871"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176342372"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/2347570"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13571-011-0014-z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2108"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511584589.011"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"677","article-title":"Clustering curves based on change point analysis: A nonparametric Bayesian approach","volume":"25","author":"Dass S. C.","year":"2015","journal-title":"Statistica Sinica"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1994.10476468"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476550"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176342360"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-234"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","unstructured":"Getz Gaddy Levine Erel &Domany Eytan(2000).Coupled two\u2010way clustering analysis of gene microarray data. InProceedings of the National Academy of Sciences of the United States of America 97 pp.12 079\u201312 084.","DOI":"10.1073\/pnas.210134797"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/82.4.711"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511802478"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2013.784705"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cor.2006.02.018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/03610919408813196"},{"key":"e_1_2_11_20_1","unstructured":"MacEachern S.(1999).Dependent nonparametric processes. InASA Proceedings of the Section on Bayesian Statistical Science pp.50\u201355."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/1390815"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2008.34"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.9.1194"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18968-0"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1214\/13-BA811"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2307\/1390653"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2009.00708.x"},{"key":"e_1_2_11_28_1","first-page":"554","volume-title":"Advances in Neural Information Processing Systems 12","author":"Rasmussen C.","year":"2000"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214508000000553"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/asn054"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1214\/08-BA313"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/joc.3447"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.189420"},{"key":"e_1_2_11_34_1","first-page":"234","article-title":"Semiparametric mixed models for medical monitoring data: An overview","volume":"6","author":"Szczesniak R. D.","year":"2015","journal-title":"Journal of Biometrics & Biostatistics"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.22237\/jmasm\/1462075980"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214506000000302"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9686-44-29"}],"container-title":["Stat"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sta4.279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/sta4.279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sta4.279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T13:17:30Z","timestamp":1693660650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sta4.279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/sta4.279"],"URL":"https:\/\/doi.org\/10.1002\/sta4.279","archive":["Portico"],"relation":{},"ISSN":["2049-1573","2049-1573"],"issn-type":[{"value":"2049-1573","type":"print"},{"value":"2049-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e279"}}