{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:31:37Z","timestamp":1792125097392,"version":"4.4.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T00:00:00Z","timestamp":1242259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft Research Center Molecular Physiology of the Brain","award":["Project B1\/9"],"award-info":[{"award-number":["Project B1\/9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the olfactory epithelium (OE) continuous neurogenesis is maintained throughout life. The OE is in direct contact with the external environment, and its cells are constantly exposed to pathogens and noxious substances. To maintain a functional sense of smell the OE has evolved the ability to permanently replenish olfactory receptor neurons and sustentacular cells lost during natural turnover. A cell population residing in the most basal part of the OE, the so-called basal cells (BCs), keep up this highly regulated genesis of new cells. The population of BCs is thought to include both the stem cells of the OE and various progenitor cells. In recent years a number of regulatory factors that positively and\/or negatively regulate the proliferation within the OE have been identified, but a thorough comprehension of the complex interplay of these regulatory factors and the role of the different epithelial cell types is still illusive. Combining labeling techniques, immunohistochemistry, electron microscopy, functional calcium imaging, and a bromo-2\u2032-deoxyuridine incorporation assay, we show for the first time that purinergic receptors are expressed in BCs of the OE of larval Xenopus laevis and that nucleotide-induced Ca2+ signaling in these cells is involved in the regulation of the cell turnover in the OE. Our data contribute to a better understanding of the regulation of the cell turnover in the OE in particular and also of how the proliferation of neuronal progenitor cells is regulated in general.<\/jats:p><jats:p>Disclosure of potential conflicts of interest is found at the end of this article.<\/jats:p>","DOI":"10.1002\/stem.126","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T01:07:09Z","timestamp":1242349629000},"page":"2022-2031","source":"Crossref","is-referenced-by-count":41,"title":["Purinergic Signaling Regulates Cell Proliferation of Olfactory Epithelium Progenitors"],"prefix":"10.1093","volume":"27","author":[{"given":"Thomas","family":"Hassenkl\u00f6ver","sequence":"first","affiliation":[{"name":"Department of Neurophysiology and Cellular Biophysics, University of G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"DFG Research Center for Molecular Physiology of the Brain (CMPB), University of G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Center of Anatomy, University of G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlev","family":"Schild","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology and Cellular Biophysics, University of G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"DFG Research Center for Molecular Physiology of the Brain (CMPB), University of G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Manzini","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology and Cellular Biophysics, University of G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"DFG Research Center for Molecular Physiology of the Brain (CMPB), University of G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,5,14]]},"reference":[{"key":"2022011221420466400_bib1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0014-4827(68)90191-2","article-title":"Lengthening of the generation cycle during embryonic differentiation of the mouse neural tube","volume":"49","author":"Kauffman","year":"1968","journal-title":"Exp Cell Res"},{"key":"2022011221420466400_bib2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0166-2236(95)93933-O","article-title":"Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model","volume":"18","author":"Caviness","year":"1995","journal-title":"Trends Neurosci"},{"key":"2022011221420466400_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cne.901240303","article-title":"Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats","volume":"124","author":"Altman","year":"1965","journal-title":"J Comp Neurol"},{"key":"2022011221420466400_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/cne.901370404","article-title":"Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb","volume":"137","author":"Altman","year":"1969","journal-title":"J Comp Neurol"},{"key":"2022011221420466400_bib5","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"2022011221420466400_bib6","first-page":"227","volume-title":"Ciba Foundation Symposium on Taste and Smell in Vertebrates","author":"Moulton","year":"1970"},{"key":"2022011221420466400_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-642-66880-7_2","article-title":"Handbook of Sensory Physiology","volume-title":"Development of Sensory Systems","author":"Graziadei","year":"1978"},{"key":"2022011221420466400_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01206454","article-title":"Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons","volume":"8","author":"Graziadei","year":"1979","journal-title":"J Neurocytol"},{"key":"2022011221420466400_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ar.10047","article-title":"Neural regeneration and the peripheral olfactory system","volume":"269","author":"Schwob","year":"2002","journal-title":"Anat Rec"},{"key":"2022011221420466400_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/(SICI)1096-9861(19981102)400:4<469::AID-CNE3>3.0.CO;2-8","article-title":"Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells","volume":"400","author":"Huard","year":"1998","journal-title":"J Comp Neurol"},{"key":"2022011221420466400_bib11","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0166-2236(90)90017-5","article-title":"Olfactory neurogenesis: genetic or environmental controls?","volume":"13","author":"Farbman","year":"1990","journal-title":"Trends Neurosci"},{"key":"2022011221420466400_bib12","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1523\/JNEUROSCI.16-04-01294.1996","article-title":"Sequential expression of Trks A, B, and C in the regenerating olfactory neuroepithelium","volume":"16","author":"Roskams","year":"1996","journal-title":"J Neurosci"},{"key":"2022011221420466400_bib13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00324613","article-title":"Topological relations between olfactory neurons","volume":"118","author":"Graziadei","year":"1971","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"2022011221420466400_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0040-8166(73)80010-2","article-title":"Cell dynamics in the olfactory mucosa","volume":"5","author":"Graziadei","year":"1973","journal-title":"Tissue Cell"},{"key":"2022011221420466400_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00330630","article-title":"Autoradiographic and ultrastructural observations on the frog's olfactory mucosa","volume":"116","author":"Graziadei","year":"1971","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"2022011221420466400_bib16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10735-007-9141-2","article-title":"Olfactory epithelium progenitors: insights from transgenic mice and in vitro biology","volume":"38","author":"Murdoch","year":"2007","journal-title":"J Mol Histol"},{"key":"2022011221420466400_bib17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jemt.10151","article-title":"Cellular and molecular biology of ensheathing cells","volume":"58","author":"Chuah","year":"2002","journal-title":"Microsc Res Tech"},{"key":"2022011221420466400_bib18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/jemt.10147","article-title":"Progenitor cells of the olfactory receptor neuron lineage","volume":"58","author":"Calof","year":"2002","journal-title":"Microsc Res Tech"},{"key":"2022011221420466400_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cne.903630111","article-title":"An immunochemical, ultrastructural, and developmental characterization of the horizontal basal cells of rat olfactory epithelium","volume":"363","author":"Holbrook","year":"1995","journal-title":"J Comp Neurol"},{"key":"2022011221420466400_bib20","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1523\/JNEUROSCI.0330-04.2004","article-title":"Olfactory horizontal basal cells demonstrate a conserved multipotent progenitor phenotype","volume":"24","author":"Carter","year":"2004","journal-title":"J Neurosci"},{"key":"2022011221420466400_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0896-6273(94)90351-4","article-title":"Globose basal cells are neuronal progenitors in the olfactory epithelium: a lineage analysis using a replication-incompetent retrovirus","volume":"13","author":"Caggiano","year":"1994","journal-title":"Neuron"},{"key":"2022011221420466400_bib22","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1523\/JNEUROSCI.11-11-03556.1991","article-title":"Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography","volume":"11","author":"Schwartz Levey","year":"1991","journal-title":"J Neurosci"},{"key":"2022011221420466400_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.yexcr.2005.03.027","article-title":"Identification and molecular regulation of neural stem cells in the olfactory epithelium","volume":"306","author":"Beites","year":"2005","journal-title":"Exp Cell Res"},{"key":"2022011221420466400_bib24","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nn1882","article-title":"Contribution of olfactory neural stem cells to tissue maintenance and regeneration","volume":"10","author":"Leung","year":"2007","journal-title":"Nat Neurosci"},{"key":"2022011221420466400_bib25","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1634\/stemcells.2007-0891","article-title":"Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium","volume":"26","author":"Iwai","year":"2008","journal-title":"Stem Cells"},{"key":"2022011221420466400_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0014-4886(92)90221-B","article-title":"Ablation of the olfactory bulb up-regulates the rate of neurogenesis and induces precocious cell death in olfactory epithelium","volume":"115","author":"Carr","year":"1992","journal-title":"Exp Neurol"},{"key":"2022011221420466400_bib27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/(SICI)1097-4695(199808)36:2<190::AID-NEU7>3.0.CO;2-X","article-title":"The neuronal stem cell of the olfactory epithelium","volume":"36","author":"Calof","year":"1998","journal-title":"J Neurobiol"},{"key":"2022011221420466400_bib28","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1523\/JNEUROSCI.23-05-01792.2003","article-title":"Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium","volume":"23","author":"Bauer","year":"2003","journal-title":"J Neurosci"},{"key":"2022011221420466400_bib29","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1242\/dev.127.24.5403","article-title":"Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage","volume":"127","author":"Shou","year":"2000","journal-title":"Development"},{"key":"2022011221420466400_bib30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0896-6273(02)01172-8","article-title":"Autoregulation of neurogenesis by GDF11","volume":"37","author":"Wu","year":"2003","journal-title":"Neuron"},{"key":"2022011221420466400_bib31","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/0896-6273(94)90047-7","article-title":"Genesis of olfactory receptor neurons in vitro: regulation of progenitor cell divisions by fibroblast growth factors","volume":"13","author":"DeHamer","year":"1994","journal-title":"Neuron"},{"key":"2022011221420466400_bib32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/(SICI)1097-4695(199606)30:2<267::AID-NEU8>3.0.CO;2-3","article-title":"Transforming growth factor-\u03b1 and other growth factors stimulate cell division in olfactory epithelium in vitro","volume":"30","author":"Farbman","year":"1996","journal-title":"J Neurobiol"},{"key":"2022011221420466400_bib33","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/7251","article-title":"BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor","volume":"2","author":"Shou","year":"1999","journal-title":"Nat Neurosci"},{"key":"2022011221420466400_bib34","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.mcn.2003.08.001","article-title":"Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium","volume":"24","author":"Simpson","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"2022011221420466400_bib35","doi-asserted-by":"crossref","first-page":"8291","DOI":"10.1523\/JNEUROSCI.23-23-08291.2003","article-title":"Activation of purinergic receptor subtypes modulates odor sensitivity","volume":"23","author":"Hegg","year":"2003","journal-title":"J Neurosci"},{"key":"2022011221420466400_bib36","first-page":"252","article-title":"Dopamine promotes differentiation of olfactory neuron in vitro","volume":"845","author":"Feron","year":"1999","journal-title":"Brain Res"},{"key":"2022011221420466400_bib37","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4067\/S0716-97602006000500002","article-title":"Role of nitric oxide during neurogenesis in the olfactory epithelium","volume":"39","author":"Sulz","year":"2006","journal-title":"Biol Res"},{"key":"2022011221420466400_bib38","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1460-9568.2005.04355.x","article-title":"Regulation of adult olfactory neurogenesis by insulin-like growth factor-I","volume":"22","author":"McCurdy","year":"2005","journal-title":"Eur J Neurosci"},{"key":"2022011221420466400_bib39","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1749-6632.1998.tb10579.x","article-title":"Alterations in the neurotrophic factors BDNF, GDNF and CNTF in the regenerating olfactory system","volume":"855","author":"Buckland","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"2022011221420466400_bib40","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00424-006-0067-4","article-title":"Nucleotide signaling in nervous system development","volume":"452","author":"Zimmermann","year":"2006","journal-title":"Pflugers Arch"},{"key":"2022011221420466400_bib41","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1242\/dev.02233","article-title":"Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation","volume":"133","author":"Mishra","year":"2006","journal-title":"Development"},{"key":"2022011221420466400_bib42","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.neuroscience.2007.07.064","article-title":"The ectonucleotidases alkaline phosphatase and nucleoside triphosphate diphosphohydrolase 2 are associated with subsets of progenitor cell populations in the mouse embryonic, postnatal and adult neurogenic zones","volume":"150","author":"Langer","year":"2007","journal-title":"Neuroscience"},{"key":"2022011221420466400_bib43","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/jnr.20508","article-title":"Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampus","volume":"80","author":"Shukla","year":"2005","journal-title":"J Neurosci Res"},{"key":"2022011221420466400_bib44","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1111\/j.0953-816X.2004.03346.x","article-title":"Functional maturation of isolated neural progenitor cells from the adult rat hippocampus","volume":"19","author":"Hogg","year":"2004","journal-title":"Eur J Neurosci"},{"key":"2022011221420466400_bib45","volume-title":"Normal Table of Xenopus laevis (Daudin)","author":"Nieuwkoop","year":"1994"},{"key":"2022011221420466400_bib46","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1113\/jphysiol.2002.033175","article-title":"Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles","volume":"546","author":"Manzini","year":"2003","journal-title":"J Physiol"},{"key":"2022011221420466400_bib47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jneumeth.2007.07.018","article-title":"Improved fluorescent (calcium indicator) dye uptake in brain slices by blocking multidrug resistance transporters","volume":"167","author":"Manzini","year":"2008","journal-title":"J Neurosci Methods"},{"key":"2022011221420466400_bib48","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/glia.20714","article-title":"Nucleotide-induced Ca2+ signaling in sustentacular supporting cells of the olfactory epithelium","volume":"56","author":"Hassenkl\u00f6ver","year":"2008","journal-title":"Glia"},{"key":"2022011221420466400_bib49","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol"},{"key":"2022011221420466400_bib50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1460-9568.2005.04533.x","article-title":"ATP activates both receptor and sustentacular supporting cells in the olfactory epithelium of Xenopus laevis tadpoles","volume":"23","author":"Czesnik","year":"2006","journal-title":"Eur J Neurosci"},{"key":"2022011221420466400_bib51","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/scdb.1996.0138","article-title":"Cellular and molecular interactions in the development of the Xenopus olfactory system","volume":"8","author":"Reiss","year":"1997","journal-title":"Semin Cell Dev Biol"},{"key":"2022011221420466400_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s004410000208","article-title":"Structure of the olfactory bulb in tadpoles of Xenopus laevis","volume":"302","author":"Nezlin","year":"2000","journal-title":"Cell Tissue Res"},{"key":"2022011221420466400_bib53","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1113\/jphysiol.2002.031914","article-title":"cAMP-independent responses of olfactory neurons in Xenopus laevis tadpoles and their projection onto olfactory bulb neurons","volume":"545","author":"Manzini","year":"2002","journal-title":"J Physiol"},{"key":"2022011221420466400_bib54","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1113\/jphysiol.2003.043059","article-title":"cAMP-independent olfactory transduction of amino acids in Xenopus laevis tadpoles","volume":"551","author":"Manzini","year":"2003","journal-title":"J Physiol"},{"key":"2022011221420466400_bib55","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1113\/jphysiol.2007.130518","article-title":"Response profiles to amino acid odorants of olfactory glomeruli in larval Xenopus laevis","volume":"581","author":"Manzini","year":"2007","journal-title":"J Physiol"},{"key":"2022011221420466400_bib56","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1460-9568.2007.05731.x","article-title":"Presynaptic protein distribution and odour mapping in glomeruli of the olfactory bulb of Xenopus laevis tadpoles","volume":"26","author":"Manzini","year":"2007","journal-title":"Eur J Neurosci"},{"key":"2022011221420466400_bib57","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/(SICI)1096-9861(19980824)398:2<273::AID-CNE8>3.0.CO;2-Y","article-title":"Ultrastructure of the olfactory organ in the clawed frog, Xenopus laevis, during larval development and metamorphosis","volume":"398","author":"Hansen","year":"1998","journal-title":"J Comp Neurol"},{"key":"2022011221420466400_bib58","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0896-6273(89)90120-7","article-title":"Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro","volume":"3","author":"Calof","year":"1989","journal-title":"Neuron"},{"key":"2022011221420466400_bib59","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/(SICI)1098-1136(199804)22:4<315::AID-GLIA1>3.0.CO;2-2","article-title":"Supporting cell proliferation in the olfactory epithelium decreases postnatally","volume":"22","author":"Weiler","year":"1998","journal-title":"Glia"},{"key":"2022011221420466400_bib60","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic","year":"1998","journal-title":"Pharmacol Rev"},{"key":"2022011221420466400_bib61","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.pharmthera.2005.08.014","article-title":"Pharmacological profiles of cloned mammalian P2Y-receptor subtypes","volume":"110","author":"von K\u00fcgelgen","year":"2006","journal-title":"Pharmacol Ther"},{"key":"2022011221420466400_bib62","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00018-005-5083-6","article-title":"The cell cycle: a new entry in the field of Ca2+ signaling","volume":"62","author":"Santella","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"2022011221420466400_bib63","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1006\/bbrc.1996.0750","article-title":"P2Upurinergic activation leads to the cell cycle progression from the G1 to the S and M phases but not from the G0 to G1 phase in vascular smooth muscle cells in primary culture","volume":"222","author":"Miyagi","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"2022011221420466400_bib64","doi-asserted-by":"crossref","first-page":"17816","DOI":"10.1016\/S0021-9258(19)84646-X","article-title":"Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum","volume":"264","author":"Seidler","year":"1989","journal-title":"J Biol Chem"},{"key":"2022011221420466400_bib65","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00018-007-6497-0","article-title":"Purine and pyrimidine receptors","volume":"64","author":"Burnstock","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"2022011221420466400_bib66","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/pr.58.3.3","article-title":"International Union of Pharmacology. LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy","volume":"58","author":"Abbracchio","year":"2006","journal-title":"Pharmacol Rev"},{"key":"2022011221420466400_bib67","doi-asserted-by":"crossref","first-page":"12583","DOI":"10.1074\/jbc.272.19.12583","article-title":"Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos","volume":"272","author":"Bogdanov","year":"1997","journal-title":"J Biol Chem"},{"key":"2022011221420466400_bib68","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1124\/mol.64.4.785","article-title":"Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules","volume":"64","author":"Lazarowski","year":"2003","journal-title":"Mol Pharmacol"},{"key":"2022011221420466400_bib69","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/15216540600794526","article-title":"Pannexin: to gap or not to gap, is that a question?","volume":"58","author":"Dahl","year":"2006","journal-title":"IUBMB Life"},{"key":"2022011221420466400_bib70","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF00307095","article-title":"Extrinsic innervation of olfactory epithelium","volume":"138","author":"Graziadei","year":"1973","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"2022011221420466400_bib71","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s002100000309","article-title":"Extracellular metabolism of ATP and other nucleotides","volume":"362","author":"Zimmermann","year":"2000","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2022011221420466400_bib72","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/glia.20792","article-title":"Calcium store-mediated signaling in sustentacular cells of the mouse olfactory epithelium","volume":"57","author":"Hegg","year":"2009","journal-title":"Glia"},{"key":"2022011221420466400_bib73","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.febslet.2005.12.004","article-title":"Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium","volume":"580","author":"Locovei","year":"2006","journal-title":"FEBS Lett"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/27\/8\/2022\/41949045\/stmcls_27_8_2022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/27\/8\/2022\/41949045\/stmcls_27_8_2022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T12:22:26Z","timestamp":1739103746000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/27\/8\/2022-2031\/6402323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,14]]},"references-count":73,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2009,5,14]]},"published-print":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.126","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,8,1]]},"published":{"date-parts":[[2009,5,14]]}}}