{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:43:29Z","timestamp":1791236609344,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH","award":["NCT01011244"],"award-info":[{"award-number":["NCT01011244"]}]},{"name":"NIH","award":["NCT01314079"],"award-info":[{"award-number":["NCT01314079"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fistula is a representative devastating complication in Crohn's patients due to refractory to conventional therapy and high recurrence. In our phase I clinical trial, adipose tissue-derived stem cells (ASCs) demonstrated their safety and therapeutic potential for healing fistulae associated with Crohn's disease. This study was carried out to evaluate the efficacy and safety of ASCs in patients with Crohn's fistulae. In this phase II study, forty-three patients were treated with ASCs. The amount of ASCs was proportioned to fistula size and fistula tract was filled with ASCs in combination with fibrin glue after intralesional injection of ASCs. Patients without complete closure of fistula at 8 weeks received a second injection of ASCs containing 1.5 times more cells than the first injection. Fistula healing at week 8 after final dose injection and its sustainability for 1-year were evaluated. Healing was defined as a complete closure of external opening without any sign of drainage and inflammation. A modified per-protocol analysis showed that complete fistula healing was observed in 27\/33 patients (82%) by 8 weeks after ASC injection. Of 27 patients with fistula healing, 26 patients completed additional observation study for 1-year and 23 patients (88%) sustained complete closure. There were no adverse events related to ASC administration. ASC treatment for patients with Crohn's fistulae was well tolerated, with a favorable therapeutic outcome. Furthermore, complete closure was well sustained. These results strongly suggest that autologous ASC could be a novel treatment option for the Crohn's fistula with high-risk of recurrence.<\/jats:p>","DOI":"10.1002\/stem.1357","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T07:00:17Z","timestamp":1360738817000},"page":"2575-2581","source":"Crossref","is-referenced-by-count":241,"title":["Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula"],"prefix":"10.1093","volume":"31","author":[{"given":"Woo Yong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Beom","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Nam","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Ho","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Surgery Daehang Hospital, Seocho-gu, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Daehang Hospital, Seocho-gu, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hun","family":"Jung","sequence":"additional","affiliation":[{"name":"Yeungnam University Medical Center, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Anterogen Co., Ltd., Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Won","family":"Yoo","sequence":"additional","affiliation":[{"name":"Anterogen Co., Ltd., Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inok","family":"Kim","sequence":"additional","affiliation":[{"name":"Anterogen Co., Ltd., Seoul, Korea"},{"name":"Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling & Drug Discovery Research College of Pharmacy, Ewha Womans University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunjoo","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling & Drug Discovery Research College of Pharmacy, Ewha Womans University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Sik","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"2022011119044231500_stem1357-bib-0001","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ibd.20352","article-title":"New global map of Crohn's disease: Genetic, environmental, and socioeconomic correlations","volume":"14","author":"Economou","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"2022011119044231500_stem1357-bib-0002","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/ibd.20310","article-title":"Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005: A KASID study","volume":"14","author":"Yang","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"2022011119044231500_stem1357-bib-0003","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1053\/j.gastro.2004.02.072","article-title":"From symptom to diagnosis: Clinical distinctions among various forms of intestinal inflammation","volume":"126","author":"Sands","year":"2004","journal-title":"Gastroenterology"},{"key":"2022011119044231500_stem1357-bib-0004","first-page":"1503","article-title":"American Gastroenterological Association medical position statement: Perianal Crohn's disease","volume":"125","author":"American Gastroenterological Association Clinical Practice Committee","year":"2003","journal-title":"Gastroenterology"},{"issue":"4 pt1","key":"2022011119044231500_stem1357-bib-0005","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0016-5085(75)80270-8","article-title":"et al. 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