{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:41:08Z","timestamp":1770910868133,"version":"3.50.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH awards: RC1","award":["HL099461"],"award-info":[{"award-number":["HL099461"]}]},{"name":"NIH RO1","award":["HL075585"],"award-info":[{"award-number":["HL075585"]}]},{"name":"NIH RO1","award":["HL075585-S1"],"award-info":[{"award-number":["HL075585-S1"]}]},{"name":"NIH RO1","award":["HL107686"],"award-info":[{"award-number":["HL107686"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Tissue-specific stem cell (TSC) number is tightly regulated in normal individuals but can change following severe injury. We previously showed that tracheobronchial epithelial TSC number increased after severe naphthalene (NA) injury and then returned to normal. This study focused on the fate of the supernumerary TSC and the signals that regulate TSC pool size. We used the Keratin 5-rTA\/Histone 2B:green fluorescent protein (GFP) model to purify basal cells that proliferated infrequently (GFPbright) or frequently (GFPdim) after NA injury. Both populations contained TSC but TSCs were 8.5-fold more abundant in the GFPbright population. Interestingly, both populations also contained a unipotential basal progenitor (UPB), a mitotic basal cell subtype whose daughters were terminally differentiated basal cells. The ratio of TSC to UPB was 5:1 in the GFPbright population and 1:5 in the GFPdim population. These data suggested that TSC proliferation in vivo promoted TSC-to-UPB differentiation. To evaluate this question, we cloned TSC from the GFPbright and GFPdim populations and passaged the clones seven times. We found that TSC number decreased and UPB number increased at each passage. Reciprocal changes in TSC and UPB frequency were more dramatic in the GFPdim lineage. Gene expression analysis showed that \u03b2-catenin and Notch pathway genes were differentially expressed in freshly isolated TSC derived from GFPbright and GFPdim populations. We conclude that (a) TSC and UPB are members of a single lineage; (b) TSC proliferation in vivo or in vitro promotes TSC-to-UPB differentiation; and (c) an interaction between the \u03b2-catenin and Notch pathways regulates the TSC-to-UPB differentiation process. Stem Cells \u00a02013;31:2767\u20132778<\/jats:p>","DOI":"10.1002\/stem.1440","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T11:42:41Z","timestamp":1369654961000},"page":"2767-2778","source":"Crossref","is-referenced-by-count":27,"title":["Regulation of Trachebronchial Tissue-Specific Stem Cell Pool Size"],"prefix":"10.1093","volume":"31","author":[{"given":"Moumita","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Jewish Health, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Jewish Health, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Runkle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Jewish Health, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas A.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Jewish Health, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Helm","sequence":"additional","affiliation":[{"name":"University of Colorado Cancer Center Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan D.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Jewish Health, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"2022011123262229000_stem1440-bib-0001","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1016\/S0960-9822(00)00033-6","article-title":"Stem cell potential: Can anything make anything?","volume":"11","author":"Morrison","year":"2001","journal-title":"Curr Biol"},{"key":"2022011123262229000_stem1440-bib-0002","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1165\/rcmb.2010-0283OC","article-title":"Context-dependent differentiation of multipotential keratin 14-expressing tracheal basal cells","volume":"45","author":"Ghosh","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2022011123262229000_stem1440-bib-0003","doi-asserted-by":"crossref","first-page":"L643","DOI":"10.1152\/ajplung.00155.2003","article-title":"In vivo differentiation potential of tracheal basal cells: Evidence for multipotent and unipotent subpopulations","volume":"286","author":"Hong","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2022011123262229000_stem1440-bib-0004","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011123262229000_stem1440-bib-0005","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1165\/rcmb.2010-0314OC","article-title":"A single cell functions as a tissue-specific stem cell and the in vitro niche-forming cell","volume":"45","author":"Ghosh","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2022011123262229000_stem1440-bib-0006","first-page":"2455","article-title":"Rawlins EL, Hogan BL. 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