{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:17:03Z","timestamp":1791263823069,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Wnt-ligands are among key morphogens that mediate patterning of the anterior territories of the developing brain in mammals. We qualified the role of Wnt-signals in regional specification and subregional organization of the human telencephalon using human pluripotent stem cells (hPSCs). One step neural conversion of hPSCs using SMAD inhibitors leads to progenitors with a default rostral identity. It provides an ideal biological substrate for investigating the role of Wnt signaling in both anteroposterior and dorso-ventral processes. Challenging hPSC-neural derivatives with Wnt-antagonists, alone or combined with sonic hedgehog (Shh), we found that Wnt-inhibition promote both telencephalic specification and ventral patterning of telencephalic neural precursors in a dose-dependent manner. Using optimal Wnt-antagonist and Shh-agonist signals we produced human ventral-telencephalic precursors, committed to differentiation into striatal projection neurons both in vitro and in vivo after homotypic transplantation in quinolinate-lesioned rats. This study indicates that sequentially organized Wnt-signals play a key role in the development of human ventral telencephalic territories from which the striatum arise. In addition, the optimized production of hPSC-derived striatal cells described here offers a relevant biological resource for exploring and curing Huntington disease.<\/jats:p>","DOI":"10.1002\/stem.1462","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T06:45:11Z","timestamp":1372747511000},"page":"1763-1774","source":"Crossref","is-referenced-by-count":110,"title":["Embryonic stem cells neural differentiation qualifies the role of Wnt\/\u03b2-Catenin signals in human telencephalic specification and regionalization"],"prefix":"10.1093","volume":"31","author":[{"given":"Camille","family":"Nicoleau","sequence":"first","affiliation":[{"name":"Inserm U861, I-STEM, AFM, Evry 91030, Cedex, France"},{"name":"UEVE U861, I-STEM, AFM, Evry 91030, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Varela","sequence":"additional","affiliation":[{"name":"CECS, I-STEM, AFM, Evry 91030, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bonnefond","sequence":"additional","affiliation":[{"name":"CECS, I-STEM, AFM, Evry 91030, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Maury","sequence":"additional","affiliation":[{"name":"CECS, I-STEM, AFM, Evry 91030, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Bugi","sequence":"additional","affiliation":[{"name":"CECS, I-STEM, AFM, Evry 91030, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Aubry","sequence":"additional","affiliation":[{"name":"Inserm U861, I-STEM, AFM, Evry 91030, Cedex, France"},{"name":"UEVE U861, I-STEM, AFM, Evry 91030, Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Viegas","sequence":"additional","affiliation":[{"name":"Inserm U861, I-STEM, AFM, Evry 91030, Cedex, 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