{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:01:13Z","timestamp":1761418873790},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Achieving efficient \u03b2-cell regeneration is a major goal of diabetes research. Previously, we found that a combination of \u03b2-cell ablation and pancreatic duct ligation led to \u03b2-cell regeneration by direct conversion from \u03b1-cells. Here, we studied the effect of surgical reversal of the duct ligation, finding that there was a wave of \u03b2-cell replication following reversal. The combination of \u03b2-cell neogenesis prior to reversal of the duct ligation and \u03b2-cell replication following reversal resulted in efficient \u03b2-cell regeneration and eventual recovery of function. This provides an important proof of principle that efficient \u03b2-cell regeneration is possible, even from a starting point of profound \u03b2-cell ablation. This has important implications for efforts to promote \u03b2-cell regeneration.<\/jats:p>","DOI":"10.1002\/stem.1492","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T19:55:19Z","timestamp":1375818919000},"page":"2388-2395","source":"Crossref","is-referenced-by-count":12,"title":["Efficient \u03b2-cell regeneration by a combination of neogenesis and replication following \u03b2-cell ablation and reversal of pancreatic duct ligation"],"prefix":"10.1093","volume":"31","author":[{"given":"Ergeng","family":"Hao","sequence":"first","affiliation":[{"name":"Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA"},{"name":"Pediatric Diabetes Research Center University of California, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Levine","sequence":"additional","affiliation":[{"name":"Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"2022011119044437700_stem1492-bib-0001","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4161\/isl.3.4.16338","article-title":"beta-Cell replication and islet neogenesis following partial pancreatectomy","volume":"3","author":"Lee","year":"2011","journal-title":"Islets"},{"key":"2022011119044437700_stem1492-bib-0002","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.2337\/diab.42.12.1715","article-title":"A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development","volume":"42","author":"Bonner-Weir","year":"1993","journal-title":"Diabetes"},{"key":"2022011119044437700_stem1492-bib-0003","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2007.12.015","article-title":"Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas","volume":"132","author":"Xu","year":"2008","journal-title":"Cell"},{"key":"2022011119044437700_stem1492-bib-0004","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/stem.482","article-title":"Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells","volume":"28","author":"Chung","year":"2010","journal-title":"Stem Cells"},{"key":"2022011119044437700_stem1492-bib-0005","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2337\/db12-0848","article-title":"Beta cells are not generated in pancreatic duct ligation induced injury in adult mice","volume":"62","author":"Rankin","year":"2013","journal-title":"Diabetes"},{"key":"2022011119044437700_stem1492-bib-0006","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/gcen.2001.7638","article-title":"Species differences in susceptibility of transplanted and cultured pancreatic islets to the \u03b2-cell toxin alloxan","volume":"122","author":"Tyrberg","year":"2001","journal-title":"Gen Comp Endocrinol"},{"key":"2022011119044437700_stem1492-bib-0007","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"2022011119044437700_stem1492-bib-0008","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1172\/JCI66323","article-title":"No evidence for beta cell neogenesis in murine adult pancreas","volume":"123","author":"Xiao","year":"2013","journal-title":"J Clin Invest"},{"key":"2022011119044437700_stem1492-bib-0009","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08894","article-title":"Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss","volume":"464","author":"Thorel","year":"2010","journal-title":"Nature"},{"issue":"suppl 4","key":"2022011119044437700_stem1492-bib-0010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1463-1326.2009.01105.x","article-title":"Adult human beta-cell neogenesis?","volume":"11","author":"Demeterco","year":"2009","journal-title":"Diabetes Obes Metab"},{"key":"2022011119044437700_stem1492-bib-0011","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"2022011119044437700_stem1492-bib-0012","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.2337\/db10-0676","article-title":"Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study","volume":"59","author":"Keenan","year":"2010","journal-title":"Diabetes"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.1492","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.1492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.1492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/31\/11\/2388\/41979806\/stmcls_31_11_2388.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/31\/11\/2388\/41979806\/stmcls_31_11_2388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T02:50:38Z","timestamp":1642560638000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/31\/11\/2388-2395\/6449151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,15]]},"published-print":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.1492","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,11,1]]},"published":{"date-parts":[[2013,11,1]]}}}