{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:47:19Z","timestamp":1790369239552,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1997,5,1]],"date-time":"1997-05-01T00:00:00Z","timestamp":862444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[1997,5,1]],"date-time":"1997-05-01T00:00:00Z","timestamp":862444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["STEM CELLS"],"published-print":{"date-parts":[[1997,5]]},"DOI":"10.1002\/stem.150198","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T15:31:16Z","timestamp":1245079876000},"page":"198-206","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of Cytokines for Expansion of the Megakaryocyte and Granulocyte Lineages"],"prefix":"10.1093","volume":"15","author":[{"given":"Jennifer A.","family":"LaIuppa","sequence":"first","affiliation":[{"name":"Northwestern University Department of Chemical Engineering, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Terry","family":"Papoutsakis","sequence":"additional","affiliation":[{"name":"Northwestern University Department of Chemical Engineering, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Northwestern University Department of Chemical Engineering, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,1]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"109","article-title":"An unusual pattern of hemopoietic reconstitution in patient with acute myeloid leukemia transplanted with autologous recovery phase peripheral blood.","volume":"6","author":"To LB","year":"1990","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_3_2","first-page":"297a","article-title":"Phase I evaluation of ex vivo expanded hematopoietic cells produced by perfusion cultures in autologous bone marrow transplantation (BMT).","volume":"82","author":"Silver SM","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_4_2","first-page":"295a","article-title":"Ex vivo expanded progenitor cell transplantation in patients with breast cancer.","volume":"86","author":"Champlin R","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1182\/blood.V87.5.1687.1687","article-title":"Selection and expansion of peripheral blood CD34+ cells in autologous stem cell transplantation for breast cancer.","volume":"87","author":"Williams SF","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508033330503"},{"key":"e_1_2_6_7_2","first-page":"294a","article-title":"A Phase I study to evaluate the safety of re\u2010infusing CD34 cells expanded ex vivo as part or all of a PBPC transplant procedure.","volume":"86","author":"Holyoake TL","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1182\/blood.V86.2.540.bloodjournal862540","article-title":"Purification and biologic characterization of plasma\u2010derived megakaryocyte growth and development factor.","volume":"86","author":"Hunt P","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530130313"},{"key":"e_1_2_6_10_2","first-page":"371","article-title":"Effect of recombinant and purified hematopoietic growth factors on human megakaryocyte colony formation.","volume":"16","author":"Bruno E","year":"1988","journal-title":"Exp Hematol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1182\/blood.V79.2.365.365","article-title":"Effects of the stem cell factor, c\u2010kit ligand, on human megakaryocytic cells.","volume":"79","author":"Avraham H","year":"1992","journal-title":"Blood"},{"key":"e_1_2_6_12_2","first-page":"11","article-title":"Hematopoietic growth factors and human megakaryocyte differentiation.","volume":"9","author":"Debili N","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1182\/blood.V82.1.84.bloodjournal82184","article-title":"Effects of the recombinant hematopoietic growth factors interleukin\u20103, interleukin\u20106, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells.","volume":"82","author":"Debili N","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.15.5953"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1182\/blood.V78.8.1969.1969","article-title":"Interleukin\u20106 supports human megakaryocytic proliferation and differentiation in vitro.","volume":"78","author":"Imai T","year":"1991","journal-title":"Blood"},{"key":"e_1_2_6_16_2","first-page":"1038","article-title":"Effect of interleukin 6 on in vitro human megakaryocytopoiesis: its interaction with other cytokines.","volume":"17","author":"Bruno E","year":"1989","journal-title":"Exp Hematol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1182\/blood.V73.7.1828.1828","article-title":"Interleukin\u20106 interacts with interleukin\u20104 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic, erythroid, myeloid, and multipotential progenitor cells.","volume":"73","author":"Rennick D","year":"1989","journal-title":"Blood"},{"key":"e_1_2_6_18_2","first-page":"1095","article-title":"The role of interleukin 6 and interleukin 1 in megakaryocyte development.","volume":"17","author":"Warren M","year":"1989","journal-title":"Exp Hematol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1182\/blood.V79.2.332.332","article-title":"Role of cytokines in sustaining long\u2010term human megakaryocytopoiesis in vitro.","volume":"79","author":"Briddell R","year":"1992","journal-title":"Blood"},{"key":"e_1_2_6_20_2","first-page":"1011","article-title":"Effect of recombinant hemopoietic growth factors on human megakaryocyte colony formation in serum\u2010free cultures.","volume":"17","author":"Teramura M","year":"1989","journal-title":"Exp Hematol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113002"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041180115"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041130410"},{"key":"e_1_2_6_24_2","first-page":"650","article-title":"Normal human serum contains a factor(s) capable of inhibiting megakaryocyte colony formation.","volume":"10","author":"Vainchenker W","year":"1982","journal-title":"Exp Hematol"},{"key":"e_1_2_6_25_2","first-page":"1049","article-title":"The biology of hematopoietic growth factors: studies in vitro under serum\u2010deprived conditions.","volume":"18","author":"Migliaccio G","year":"1990","journal-title":"Exp Hematol"},{"key":"e_1_2_6_26_2","unstructured":"LaIuppaJA.Defined culture conditions for ex vivo expansion of megakaryocytes and myeloid progenitors. PhD Thesis Northwestern University 1996."},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0290(19960605)50:5<505::AID-BIT4>3.0.CO;2-J"},{"key":"e_1_2_6_28_2","first-page":"660a","article-title":"Seeding density affects proliferation, differentiation, and metabolic patterns of peripheral blood mononuclear cell cultures.","volume":"86","author":"Collins PC","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_29_2","first-page":"870","article-title":"Expansion of neutrophil precursors and progenitors in suspension cultures of CD34+ cells enriched from human bone marrow.","volume":"21","author":"Smith SL","year":"1993","journal-title":"Exp Hematol"},{"key":"e_1_2_6_30_2","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1182\/blood.V82.12.3600.3600","article-title":"In vitro expansion of human peripheral blood CD34+ cells.","volume":"82","author":"Sato N","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.6.1405.bloodjournal8061405"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1182\/blood.V84.10.3567.3567","article-title":"Optimization of conditions for ex vivo expansion of CD34+ cells from patients with stage IV breast cancer.","volume":"84","author":"Shapiro F","year":"1994","journal-title":"Blood"},{"key":"e_1_2_6_33_2","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1182\/blood.V81.10.2579.2579","article-title":"Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, IL\u20101beta, IL\u20106, IL\u20103, Interferon\u2010gamma, and erythropoietin.","volume":"81","author":"Brugger W","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_34_2","first-page":"807","article-title":"Granulocyte colony\u2010stimulating factor augments in vitro megakaryocyte colony formation by interleukin\u20103.","volume":"16","author":"McNiece IK","year":"1988","journal-title":"Exp Hematol"},{"key":"e_1_2_6_35_2","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1182\/blood.V85.7.1719.bloodjournal8571719","article-title":"Thrombopoietin (c\u2010mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin\u201011 to enhance murine megakaryocytic colony growth and increases megakaryocyte ploidy in vitro.","volume":"85","author":"Broudy VC","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_36_2","first-page":"368a","article-title":"Effects of thrombopoietin on megakaryocyte colony formation and ploidy by human CD34 positive cells in a serum\u2010free system.","volume":"86","author":"Angchaisuksiri P","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_37_2","first-page":"1","article-title":"Clinical implications of positive and negative hematopoietic stem cell regulators.","volume":"78","author":"Moore M","year":"1991","journal-title":"Blood"},{"key":"e_1_2_6_38_2","first-page":"857","article-title":"New hats for hematopoietic hormones.","volume":"19","author":"Sieff CA","year":"1991","journal-title":"Exp Hematol"},{"key":"e_1_2_6_39_2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1182\/blood.V86.4.1331.bloodjournal8641331","article-title":"Modulation of megakaryocytopoiesis by thrombopoietin: the c\u2010mpl ligand.","volume":"86","author":"Banu N","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_40_2","first-page":"660","article-title":"Insights into the cellular mechanisms of erythropoietin\u2010thrombopoietin synergy.","volume":"24","author":"Papayannopoulou T","year":"1996","journal-title":"Exp Hematol"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530130208"},{"key":"e_1_2_6_42_2","first-page":"364a","article-title":"Megakaryopoiesis in vitro: effects of various cytokines including thrombopoietin (TPO) on the growth and generation of murine megakaryocyte colony\u2010forming cells (Meg\u2010CFC).","volume":"86","author":"Sotiropoulos D","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_43_2","first-page":"419a","article-title":"The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells.","volume":"86","author":"Sitnicka E","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_44_2","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1182\/blood.V84.9.2898.2898","article-title":"Maintenance of transplantation potential in ex vivo expanded CD34+\u2010selected human peripheral blood progenitor cells.","volume":"84","author":"Henschler R","year":"1994","journal-title":"Blood"},{"key":"e_1_2_6_45_2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1182\/blood.V82.2.378.378","article-title":"Large\u2010scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures.","volume":"82","author":"Koller MR","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_46_2","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1182\/blood.V86.3.958.958","article-title":"Effects of CD34+ cell selection and perfusion on ex vivo expansion of peripheral blood mononuclear cells.","volume":"86","author":"Sandstrom CE","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08002.x"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530120610"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.1.1996.5.461"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.1.1992.1.329"}],"container-title":["STEM CELLS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.150198","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.150198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.150198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.150198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T02:50:50Z","timestamp":1642560650000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/15\/3\/198-206\/6390463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,5]]}},"alternative-id":["10.1002\/stem.150198"],"URL":"https:\/\/doi.org\/10.1002\/stem.150198","archive":["Portico"],"relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5]]}}}