{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:33:25Z","timestamp":1791254005232,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The junctional adhesion molecules Jam-b and Jam-c interact together at interendothelial junctions and have been involved in the regulation of immune response, inflammation, and leukocyte migration. More recently, Jam-c has been found to be expressed by hematopoietic stem and progenitor cells (HSPC) in mouse. Conversely, we have reported that Jam-b is present on bone marrow stromal cells and that Jam-b-deficient mice have defects in the regulation of hematopoietic stem cell pool. In this study, we have addressed whether interaction between Jam-b and Jam-c participates to HSPC mobilization or hematopoietic reconstitution after irradiation. We show that a blocking monoclonal antibody directed against Jam-c inhibits hematopoietic reconstitution, progenitor homing to the bone marrow, and induces HSPC mobilization in a Jam-b dependent manner. In the latter setting, antibody treatment over a period of 3 days does not alter hematopoietic differentiation nor induce leukocytosis. Results are translated to human hematopoietic system in which a functional adhesive interaction between JAM-B and JAM-C is found between human HSPC and mesenchymal stem cells. Such an interaction does not occur between HSPC and human endothelial cells or osteoblasts. It is further shown that anti-JAM-C blocking antibody interferes with CD34+ hematopoietic progenitor homing in mouse bone marrow suggesting that monoclonal antibodies inhibiting JAM-B\/JAM-C interaction may represent valuable therapeutic tools to improve stem cell mobilization protocols. Stem Cells \u00a02014;32:1043\u20131054<\/jats:p>","DOI":"10.1002\/stem.1624","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T15:14:50Z","timestamp":1387466090000},"page":"1043-1054","source":"Crossref","is-referenced-by-count":48,"title":["Function of Jam-B\/Jam-C Interaction in Homing and Mobilization of Human and Mouse Hematopoietic Stem and Progenitor Cells"],"prefix":"10.1093","volume":"32","author":[{"given":"Marie-Laure","family":"Arcangeli","sequence":"first","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille, InsermUMR1068, Marseille, France"},{"name":"Institut Paoli-Calmettes, Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Marseille, France"},{"name":"CNRS, UMR7258, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Bardin","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille, InsermUMR1068, Marseille, France"},{"name":"Institut Paoli-Calmettes, Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Marseille, France"},{"name":"CNRS, UMR7258, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Frontera","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille, InsermUMR1068, Marseille, France"},{"name":"Institut Paoli-Calmettes, Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Marseille, France"},{"name":"CNRS, UMR7258, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislain","family":"Bidaut","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille, InsermUMR1068, Marseille, France"},{"name":"Institut Paoli-Calmettes, Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Marseille, France"},{"name":"CNRS, UMR7258, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Obrados","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille, InsermUMR1068, Marseille, France"},{"name":"Institut Paoli-Calmettes, Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Marseille, France"},{"name":"CNRS, UMR7258, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf H.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Tissue Morphogenesis Max-Planck-Institute for Molecular Biomedicine and Faculty of Medicine, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Chabannon","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille, InsermUMR1068, Marseille, France"},{"name":"Institut Paoli-Calmettes, Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Marseille, France"},{"name":"Inserm, CBT-510, Centre d\u2019Investigations Cliniques en Bioth\u00e9rapie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Aurrand-Lions","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille, InsermUMR1068, Marseille, France"},{"name":"Institut Paoli-Calmettes, Marseille, France"},{"name":"Aix-Marseille Universit\u00e9, Marseille, France"},{"name":"CNRS, UMR7258, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,3,17]]},"reference":[{"key":"2022011200495349200_stem1624-bib-0001","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1471-4906(03)00117-0","article-title":"Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory 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