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Thus, the objectives of this study were to examine the potential enhanced efficacy arising from addition of CQ to standard chemotherapy (paclitaxel) in TNBC and to identify the mechanism by which CQ eliminates CSCs in TNBCs. Herein, we report that CQ sensitizes TNBC cells to paclitaxel through inhibition of autophagy and reduces the CD44+\/CD24\u2212\/low CSC population in both preclinical and clinical settings. Also, we are the first to report a mechanism by which CQ regulates the CSCs in TNBC through inhibition of the Janus-activated kinase 2 (Jak2)\u2014signal transducer and activator of transcription 3 signaling pathway by reducing the expression of Jak2 and DNA methyltransferase 1. Stem Cells \u00a02014;32:2309\u20132323<\/jats:p>","DOI":"10.1002\/stem.1746","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T09:41:50Z","timestamp":1399628510000},"page":"2309-2323","source":"Crossref","is-referenced-by-count":105,"title":["Chloroquine Eliminates Cancer Stem Cells Through Deregulation of Jak2 and DNMT1"],"prefix":"10.1093","volume":"32","author":[{"given":"Dong Soon","family":"Choi","sequence":"first","affiliation":[{"name":"Methodist Cancer Center Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvin","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine Houston Methodist Research Institute, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo-Shin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Translational Imaging Houston Methodist Research Institute, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel A.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Methodist Cancer Center Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine and Bioengineering Weill Cornell Medical College, Houston Methodist Research Institute, Houston, Texas, USA"},{"name":"NCI Center for Modeling Cancer Development Houston Methodist Research Institute, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim Hui-Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine\/Institute of Biotechnology The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine\/Institute of Biotechnology The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine and Bioengineering Weill Cornell Medical College, Houston Methodist Research Institute, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa D.","family":"Landis","sequence":"additional","affiliation":[{"name":"Methodist Cancer Center Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacey A.","family":"Burey","sequence":"additional","affiliation":[{"name":"Methodist Cancer Center Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[{"name":"Methodist Cancer Center Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio M.","family":"Granados","sequence":"additional","affiliation":[{"name":"Methodist Cancer Center Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvanesh","family":"Dave","sequence":"additional","affiliation":[{"name":"Methodist Cancer Center Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Methodist Cancer Center Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine Houston Methodist Research Institute, Houston, Texas, USA"},{"name":"Weill Cornell Medical School, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T. 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