{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:36:07Z","timestamp":1791329767447,"version":"4.3.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["279174"],"award-info":[{"award-number":["279174"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mesenchymal or stromal stem cells (MSC) interact with cells of the immune system in multiple ways. Modulation of the immune system by MSC is believed to be a therapeutic option for autoimmune disease and transplant rejection. In recent years, B cells have moved into the focus of the attention as targets for the treatment of immune disorders. Current B-cell targeting treatment is based on the indiscriminate depletion of B cells. The aim of this study was to examine whether human adipose tissue-derived MSC (ASC) interact with B cells to affect their proliferation, differentiation, and immune function. ASC supported the survival of quiescent B cells predominantly via contact-dependent mechanisms. Coculture of B cells with activated T helper cells led to proliferation and differentiation of B cells into CD19+CD27highCD38high antibody-producing plasmablasts. ASC inhibited the proliferation of B cells and this effect was dependent on the presence of T cells. In contrast, ASC directly targeted B-cell differentiation, independently of T cells. In the presence of ASC, plasmablast formation was reduced and IL-10-producing CD19+CD24highCD38high B cells, known as regulatory B cells, were induced. These results demonstrate that ASC affect B cell biology in vitro, suggesting that they can be a tool for the modulation of the B-cell response in immune disease. Stem Cells \u00a02015;33:880\u2013891<\/jats:p>","DOI":"10.1002\/stem.1881","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T03:57:35Z","timestamp":1415246255000},"page":"880-891","source":"Crossref","is-referenced-by-count":203,"title":["Human Adipose Tissue-Derived Mesenchymal Stem Cells Abrogate Plasmablast Formation and Induce Regulatory B Cells Independently of T Helper Cells"],"prefix":"10.1093","volume":"33","author":[{"given":"M.","family":"Franquesa","sequence":"first","affiliation":[{"name":"Nephrology and Transplantation, Department of Internal Medicine University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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D.","family":"Laman","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Neuroscience\/Medical Physiology University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Griny\u00f3","sequence":"additional","affiliation":[{"name":"Experimental Nephrology and Transplantation Hospital Universitari de Bellvitge-IDIBELL, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Weimar","sequence":"additional","affiliation":[{"name":"Nephrology and Transplantation, Department of Internal Medicine University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G. 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