{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:46:06Z","timestamp":1790145966058,"version":"4.0.1"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":2423,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Understanding stem cell homing, which is governed by environmental signals from the surrounding niche, is important for developing effective stem cell-based repair strategies. The molecular mechanism by which the brain under ischemic stress recruits bone marrow-derived cells (BMDCs) to the vascular niche remains poorly characterized. Here we report that hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) activation upregulates pituitary adenylate cyclase-activating peptide 38 (PACAP38), which in turn activates PACAP type 1 receptor (PAC1) under hypoxia in vitro and cerebral ischemia in vivo. BMDCs homing to endothelial cells in the ischemic brain are mediated by HIF-1\u03b1 activation of the PACAP38-PAC1 signaling cascade followed by upregulation of cellular prion protein and \u03b16-integrin to enhance the ability of BMDCs to bind laminin in the vascular niche. Exogenous PACAP38 confers a similar effect in facilitating BMDCs homing into the ischemic brain, resulting in reduction of ischemic brain injury. These findings suggest a novel HIF-1\u03b1-activated PACAP38-PAC1 signaling process in initiating BMDCs homing into the ischemic brain for reducing brain injury and enhancing functional recovery after ischemic stroke. Stem Cells \u00a02015;33:1153\u20131172<\/jats:p>","DOI":"10.1002\/stem.1915","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:32:04Z","timestamp":1418981524000},"page":"1153-1172","source":"Crossref","is-referenced-by-count":20,"title":["PACAP38\/PAC1 Signaling Induces Bone Marrow-Derived Cells Homing to Ischemic Brain"],"prefix":"10.1093","volume":"33","author":[{"given":"Chen-Huan","family":"Lin","sequence":"first","affiliation":[{"name":"Center for Neuropsychiatry and Translational Medicine Research Center China Medical University and Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Nursing College of Medicine and Nursing, Hungkuang University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsu-Tung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Taichung Veterans General Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wei","family":"Chiang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Science, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry and Translational Medicine Research Center China Medical University and Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Basic Science, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Hsiang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pathology Buddhist Tzu-Chi General Hospital, Tzu-Chi University, Hualien, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinn-Zong","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatry and Translational Medicine Research Center China Medical University and Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Immunology, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Y.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hung","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan"},{"name":"Department of Biomedical Informatics Asia University, Taichung, 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