{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:43:36Z","timestamp":1789944216662,"version":"4.0.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":2365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Research on Regenerative Medicine for Clinical Application from the Ministry of Health, Labor and Welfare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although meniscus defects and degeneration are strongly correlated with the later development of osteoarthritis, the promise of regenerative medicine strategies is to prevent and\/or delay the disease's progression. Meniscal reconstruction has been shown in animal models with tendon grafting and transplantation of mesenchymal stem cells (MSCs); however, these procedures have not shown the same efficacy in clinical studies. Here, our aim was to investigate the ability of tendon grafts pretreated with exogenous synovial-derived MSCs to prevent cartilage degeneration in a rat partial meniscus defect model. We removed the anterior half of the medial meniscus and grafted autologous Achilles tendons with or without a 10-minute pretreatment of the tendon with synovial MSCs. The meniscus and surrounding cartilage were evaluated at 2, 4, and 8 weeks (n\u2009=\u20095). Tendon grafts increased meniscus size irrespective of synovial MSCs. Histological scores for regenerated menisci were better in the tendon + MSC group than in the other two groups at 4 and 8 weeks. Both macroscopic and histological scores for articular cartilage were significantly better in the tendon + MSC group at 8 weeks. Implanted synovial MSCs survived around the grafted tendon and native meniscus integration site by cell tracking assays with luciferase+, LacZ+, DiI+, and\/or GFP+ synovial MSCs and\/or GFP+ tendons. Flow cytometric analysis showed that transplanted synovial MSCs retained their MSC properties at 7 days and host synovial tissue also contained cells with MSC characteristics. Synovial MSCs promoted meniscus regeneration augmented by autologous Achilles tendon grafts and prevented cartilage degeneration in rats. Stem Cells \u00a02015;33:1927\u20131938<\/jats:p>","DOI":"10.1002\/stem.2030","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T07:38:29Z","timestamp":1432193909000},"page":"1927-1938","source":"Crossref","is-referenced-by-count":58,"title":["Synovial Mesenchymal Stem Cells Promote Meniscus Regeneration Augmented by an Autologous Achilles Tendon Graft in a Rat Partial Meniscus Defect Model"],"prefix":"10.1093","volume":"33","author":[{"given":"Nobutake","family":"Ozeki","sequence":"first","affiliation":[{"name":"Department of Joint Surgery and Sports medicine, Yokohama, Japan"},{"name":"Department of Orthopaedic Surgery Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Muneta","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery and Sports medicine, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Matsuta","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery and Sports medicine, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery and Sports medicine, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery and Sports medicine, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Center for Stem Cell and Regenerative Medicine Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunikazu","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Cartilage Regeneration Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Graduate School of Health care Science Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Graduate School of Health care Science Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Organ Fabrication Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Sekiya","sequence":"additional","affiliation":[{"name":"Center for Stem Cell and Regenerative Medicine Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"2021121023334391700_stem2030-bib-0001","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0749-8063(97)90000-1","article-title":"Fifteen-year follow-up of arthroscopic partial meniscectomy","volume":"13","author":"Burks","year":"1997","journal-title":"Arthroscopy"},{"key":"2021121023334391700_stem2030-bib-0002","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/rheumatology\/40.6.631","article-title":"Patient-relevant outcomes fourteen years after meniscectomy: Influence of type of meniscal tear and size of resection","volume":"40","author":"Englund","year":"2001","journal-title":"Rheumatology"},{"key":"2021121023334391700_stem2030-bib-0003","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2012.69","article-title":"Meniscus pathology, osteoarthritis and the treatment controversy","volume":"8","author":"Englund","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"2021121023334391700_stem2030-bib-0004","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2106\/00004623-200603000-00027","article-title":"American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, certification examination case mix","volume":"88","author":"Garrett","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"2021121023334391700_stem2030-bib-0005","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1053\/jars.2002.30435","article-title":"Arthroscopic partial and total meniscectomy: A long-term follow-up study with matched controls","volume":"18","author":"Andersson-Molina","year":"2002","journal-title":"Arthroscopy"},{"key":"2021121023334391700_stem2030-bib-0006","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/03635465010290022401","article-title":"Meniscal allografts--where do we stand?","volume":"29","author":"Rodeo","year":"2001","journal-title":"Am J Sports Med"},{"key":"2021121023334391700_stem2030-bib-0007","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.arthro.2006.11.032","article-title":"Meniscus allograft transplantation: Ten-year results of cryopreserved allografts","volume":"23","author":"Hommen","year":"2007","journal-title":"Arthroscopy"},{"key":"2021121023334391700_stem2030-bib-0008","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/bjsm.2010.081257","article-title":"Meniscal tears, repairs and replacement: Their relevance to osteoarthritis of the knee","volume":"45","author":"McDermott","year":"2011","journal-title":"Br J Sports Med"},{"key":"2021121023334391700_stem2030-bib-0009","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/0363546510391179","article-title":"Prospective long-term outcomes of the medial collagen meniscus implant versus partial medial meniscectomy: A minimum 10-year follow-up study","volume":"39","author":"Zaffagnini","year":"2011","journal-title":"Am J Sports Med"},{"key":"2021121023334391700_stem2030-bib-0010","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1302\/0301-620X.74B6.1447257","article-title":"Medial meniscus replacement by a tendon autograft. Experiments in sheep","volume":"74","author":"Kohn","year":"1992","journal-title":"J Bone Joint Surg Br"},{"key":"2021121023334391700_stem2030-bib-0011","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0749-8063(00)90035-5","article-title":"Autogenous tendon graft substitution for absent knee joint meniscus: A pilot study","volume":"16","author":"Johnson","year":"2000","journal-title":"Arthroscopy"},{"key":"2021121023334391700_stem2030-bib-0012","first-page":"19","article-title":"Material properties and structure-function relationships in the menisci","author":"Fithian","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"2021121023334391700_stem2030-bib-0013","first-page":"83","article-title":"Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method","volume":"2","author":"Friedenstein","year":"1974","journal-title":"Exp Hematol"},{"key":"2021121023334391700_stem2030-bib-0014","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.276.5309.71","article-title":"Marrow stromal cells as stem cells for nonhematopoietic tissues","volume":"276","author":"Prockop","year":"1997","journal-title":"Science"},{"key":"2021121023334391700_stem2030-bib-0015","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/art.11365","article-title":"Stem cell therapy in a caprine model of osteoarthritis","volume":"48","author":"Murphy","year":"2003","journal-title":"Arthrit Rheumat"},{"key":"2021121023334391700_stem2030-bib-0016","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.biomaterials.2012.11.039","article-title":"Repair of meniscal lesions using a scaffold-free tissue-engineered construct derived from allogenic synovial MSCs in a miniature swine model","volume":"34","author":"Moriguchi","year":"2013","journal-title":"Biomaterials"},{"key":"2021121023334391700_stem2030-bib-0017","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5966\/sctm.2012-0170","article-title":"Intra-articular injection of human meniscus stem\/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1\/CXCR4-mediated homing","volume":"3","author":"Shen","year":"2014","journal-title":"Stem Cells Transl Med"},{"key":"2021121023334391700_stem2030-bib-0018","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2106\/JBJS.M.00058","article-title":"Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: A randomized, double-blind, controlled study","volume":"96","author":"Vangsness","year":"2014","journal-title":"J Bone Joint Surg Am"},{"key":"2021121023334391700_stem2030-bib-0019","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P","article-title":"Multipotent mesenchymal stem cells from adult human synovial membrane","volume":"44","author":"Bari","year":"2001","journal-title":"Arthrit Rheumat"},{"key":"2021121023334391700_stem2030-bib-0020","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/art.21212","article-title":"Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source","volume":"52","author":"Sakaguchi","year":"2005","journal-title":"Arthrit Rheumat"},{"key":"2021121023334391700_stem2030-bib-0021","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00441-006-0308-z","article-title":"Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle","volume":"327","author":"Yoshimura","year":"2007","journal-title":"Cell Tissue Res"},{"key":"2021121023334391700_stem2030-bib-0022","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s11999-013-3418-4","article-title":"Mesenchymal stem cells in synovial fluid increase after meniscus injury","volume":"472","author":"Matsukura","year":"2014","journal-title":"Clinical Orthop Relat Res"},{"key":"2021121023334391700_stem2030-bib-0023","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1634\/stemcells.2008-0616","article-title":"Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect","volume":"27","author":"Horie","year":"2009","journal-title":"Stem Cells"},{"key":"2021121023334391700_stem2030-bib-0024","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2106\/JBJS.K.00176","article-title":"Implantation of allogenic synovial stem cells promotes meniscal regeneration in a rabbit meniscal defect model","volume":"94","author":"Horie","year":"2012","journal-title":"J Bone Joint Surg Am"},{"key":"2021121023334391700_stem2030-bib-0025","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/01.tp.0000203137.06587.4a","article-title":"\u201cFirefly rats\u201d as an organ\/cellular source for long-term in vivo bioluminescent imaging","volume":"81","author":"Hakamata","year":"2006","journal-title":"Transplantation"},{"key":"2021121023334391700_stem2030-bib-0026","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbrc.2005.01.132","article-title":"Development of new inbred transgenic strains of rats with LacZ or GFP","volume":"329","author":"Inoue","year":"2005","journal-title":"Biochem Biophys Res Comm"},{"key":"2021121023334391700_stem2030-bib-0027","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1634\/stemcells.2006-0281","article-title":"Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration","volume":"25","author":"Koga","year":"2007","journal-title":"Stem Cells"},{"key":"2021121023334391700_stem2030-bib-0028","doi-asserted-by":"crossref","first-page":"R206","DOI":"10.1186\/ar3182","article-title":"Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits","volume":"12","author":"Miyamoto","year":"2010","journal-title":"Arthrit Res Ther"},{"key":"2021121023334391700_stem2030-bib-0029","doi-asserted-by":"crossref","first-page":"R136","DOI":"10.1186\/ar3869","article-title":"Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration","volume":"14","author":"Suzuki","year":"2012","journal-title":"Arthrit Res Ther"},{"key":"2021121023334391700_stem2030-bib-0030","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1002\/art.38099","article-title":"Transplantation of Achilles tendon treated with bone morphogenetic protein 7 promotes meniscus regeneration in a rat model of massive meniscal defect","volume":"65","author":"Ozeki","year":"2013","journal-title":"Arthrit Rheumat"},{"key":"2021121023334391700_stem2030-bib-0031","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/art.21561","article-title":"The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee","volume":"54","author":"Inoue","year":"2006","journal-title":"Arthrit Rheumat"},{"key":"2021121023334391700_stem2030-bib-0032","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.joca.2011.05.008","article-title":"Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis","volume":"19","author":"Pauli","year":"2011","journal-title":"Osteoarthrit Cartil"},{"key":"2021121023334391700_stem2030-bib-0033","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data","volume":"53","author":"Mankin","year":"1971","journal-title":"J Bone Joint Surg Am"},{"key":"2021121023334391700_stem2030-bib-0034","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1177\/0363546512456835","article-title":"Arthroscopic collagen meniscus implantation for partial lateral meniscal defects: A 2-year minimum follow-up study","volume":"40","author":"Zaffagnini","year":"2012","journal-title":"Am J Sports Med"},{"key":"2021121023334391700_stem2030-bib-0035","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1177\/0363546511433032","article-title":"Successful treatment of painful irreparable partial meniscal defects with a polyurethane scaffold: Two-year safety and clinical outcomes","volume":"40","author":"Verdonk","year":"2012","journal-title":"Am J Sports Med"},{"key":"2021121023334391700_stem2030-bib-0036","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1053\/ar.1999.v15.0150611","article-title":"Two-bundle reconstruction of the anterior cruciate ligament using semitendinosus tendon with endobuttons: Operative technique and preliminary results","volume":"15","author":"Muneta","year":"1999","journal-title":"Arthroscopy"},{"key":"2021121023334391700_stem2030-bib-0037","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/14653249.2011.638912","article-title":"Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs","volume":"14","author":"Nakamura","year":"2012","journal-title":"Cytotherapy"},{"key":"2021121023334391700_stem2030-bib-0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2015.02.008","article-title":"Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs","author":"Nakagawa","year":"2015","journal-title":"Osteoarthrit Cartil"},{"key":"2021121023334391700_stem2030-bib-0039","doi-asserted-by":"crossref","first-page":"R84","DOI":"10.1186\/ar2460","article-title":"Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect","volume":"10","author":"Koga","year":"2008","journal-title":"Arthrit Res Ther"},{"key":"2021121023334391700_stem2030-bib-0040","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.joca.2012.06.002","article-title":"Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen","volume":"20","author":"Horie","year":"2012","journal-title":"Osteoarthrit Cartil"},{"key":"2021121023334391700_stem2030-bib-0041","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.joca.2010.06.005","article-title":"Magnesium enhances adherence and cartilage formation of synovial mesenchymal stem cells through integrins","volume":"18","author":"Shimaya","year":"2010","journal-title":"Osteoarthrit Cartil"},{"key":"2021121023334391700_stem2030-bib-0042","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"2021121023334391700_stem2030-bib-0043","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jor.22614","article-title":"Meniscus regeneration by syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model","volume":"32","author":"Okuno","year":"2014","journal-title":"J Orthop Res"},{"key":"2021121023334391700_stem2030-bib-0044","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1073\/pnas.1016753108","article-title":"PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia","volume":"108","author":"Tamai","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021121023334391700_stem2030-bib-0045","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcb.20886","article-title":"Mesenchymal stem cells as trophic mediators","volume":"98","author":"Caplan","year":"2006","journal-title":"J Cell Biochem"},{"key":"2021121023334391700_stem2030-bib-0046","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-004-1075-3","article-title":"Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma","volume":"320","author":"Sekiya","year":"2005","journal-title":"Cell Tissue Res"},{"issue":"Suppl 3","key":"2021121023334391700_stem2030-bib-0047","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2106\/00004623-200300003-00019","article-title":"Acceleration of regenerate ossification during distraction osteogenesis with recombinant human bone morphogenetic protein-7","volume":"85-A","author":"Mizumoto","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"2021121023334391700_stem2030-bib-0048","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/jor.22564","article-title":"Enhancement of Achilles tendon repair mediated by matrix metalloproteinase inhibition via systemic administration of doxycycline","volume":"32","author":"Kessler","year":"2014","journal-title":"J Orthopaed Res"},{"key":"2021121023334391700_stem2030-bib-0049","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative\u2014Recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthrit Cartil"},{"key":"2021121023334391700_stem2030-bib-0050","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.bbrc.2013.05.026","article-title":"Transplantation of aggregates of synovial mesenchymal stem cells regenerates meniscus more effectively in a rat massive meniscal defect","volume":"435","author":"Katagiri","year":"2013","journal-title":"Biochem Biophys Res Comm"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.2030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.2030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.2030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.2030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/33\/6\/1927\/41511384\/stmcls_33_6_1927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/33\/6\/1927\/41511384\/stmcls_33_6_1927.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T02:55:48Z","timestamp":1642560948000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/33\/6\/1927-1938\/6407321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,21]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,5,21]]},"published-print":{"date-parts":[[2015,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.2030","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,6,1]]},"published":{"date-parts":[[2015,5,21]]}}}