{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:27:52Z","timestamp":1790188072642,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T00:00:00Z","timestamp":1443916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Scientific Research","award":["25293093 (to M.S.)"],"award-info":[{"award-number":["25293093 (to M.S.)"]}]},{"name":"Scientific Research","award":["20590381\/23590444 (to Y.I.)"],"award-info":[{"award-number":["20590381\/23590444 (to Y.I.)"]}]},{"name":"Scientific Research on Innovative Areas","award":["23122506 (to S.Y.)"],"award-info":[{"award-number":["23122506 (to S.Y.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The neuroprotective agents and induction of endogenous neurogenesis remain to be the urgent issues to be established for the care of cerebral stroke. Platelet-derived growth factor receptor beta (PDGFR-\u03b2) is mainly expressed in neural stem\/progenitor cells (NSPCs), neurons and vascular pericytes of the brain; however, the role in pathological neurogenesis remains elusive. To this end, we examined the role of PDGFR-\u03b2 in the migration and proliferation of NSPCs after stroke. A transient middle cerebral-arterial occlusion (MCAO) was introduced into the mice with conditional Pdgfrb-gene inactivation, including N-PR\u03b2-KO mice where the Pdgfrb-gene was mostly inactivated in the brain except that in vascular pericytes, and E-PR\u03b2-KO mice with tamoxifen-induced systemic Pdgfrb-gene inactivation. The migration of the DCX+ neuroblasts from the subventricular zone toward the ischemic core was highly increased in N-PR\u03b2-KO, but not in E-PR\u03b2-KO as compared to Pdgfrb-gene preserving control mice. We showed that CXCL12, a potent chemoattractant for CXCR4-expressing NSPCs, was upregulated in the ischemic lesion of N-PR\u03b2-KO mice. Furthermore, integrin \u03b13 intrinsically expressed in NSPCs that critically mediates extracellular matrix-dependent migration, was upregulated in N-PR\u03b2-KO after MCAO. NSPCs isolated from N-PR\u03b2-KO rapidly migrated on the surface coated with collagen type IV or fibronectin that are abundant in vascular niche and ischemic core. PDGFR-\u03b2 was suggested to be critically involved in pathological neurogenesis through the regulation of lesion-derived chemoattractant as well as intrinsic signal of NSPCs, and we believe that a coordinated regulation of these molecular events may be able to improve neurogenesis in injured brain for further functional recovery.<\/jats:p>","DOI":"10.1002\/stem.2212","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T05:11:20Z","timestamp":1444021880000},"page":"685-698","source":"Crossref","is-referenced-by-count":27,"title":["PDGFR-\u03b2 Plays a Key Role in the Ectopic Migration of Neuroblasts in Cerebral Stroke"],"prefix":"10.1093","volume":"34","author":[{"given":"Hikari","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Toyama, Toyama, 930-0194, Japan"},{"name":"Department of Neurosurgery, University of Toyama, Toyama, 930-0194, 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