{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:27:16Z","timestamp":1787678836847,"version":"build-2784847793"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Urology Association"},{"name":"French National Institute of Health and Medical Research"},{"name":"National Research Agency"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Urinary incontinence (UI) and erectile dysfunction (ED) are the most common functional urological disorders and the main sequels of radical prostatectomy (RP) for prostate cancer. Mesenchymal stem cell (MSC) therapy holds promise for repairing tissue damage due to RP. Because animal studies accurately replicating post-RP clinical UI and ED are lacking, little is known about the mechanisms underlying the urological benefits of MSC in this setting. To determine whether and by which mechanisms MSC can repair damages to both striated urethral sphincter (SUS) and penis in the same animal, we delivered human multipotent adipose stem cells, used as MSC model, in an immunocompetent rat model replicating post-RP UI and ED. In this model, we demonstrated by using noninvasive methods in the same animal from day 7 to day 90 post-RP injury that MSC administration into both the SUS and the penis significantly improved urinary continence and erectile function. The regenerative effects of MSC therapy were not due to transdifferentiation and robust engraftment at injection sites. Rather, our results suggest that MSC benefits in both target organs may involve a paracrine process with not only soluble factor release by the MSC but also activation of the recipient's secretome. These two effects of MSC varied across target tissues and damaged-cell types. In conclusion, our work provides new insights into the regenerative properties of MSC and supports the ability of MSC from a single source to repair multiple types of damage, such as those seen after RP, in the same individual.<\/jats:p>","DOI":"10.1002\/stem.2226","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T15:42:46Z","timestamp":1444146166000},"page":"392-404","source":"Crossref","is-referenced-by-count":36,"title":["Delivery of human mesenchymal adipose-derived stem cells restores multiple urological dysfunctions in a rat model mimicking radical prostatectomy damages through tissue-specific paracrine mechanisms"],"prefix":"10.1093","volume":"34","author":[{"given":"Ren\u00e9","family":"Yiou","sequence":"first","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"},{"name":"Urology Department, APHP, H\u00f4pital H. Mondor-A. Chenevier, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Mahrouf-Yorgov","sequence":"additional","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Tr\u00e9beau","sequence":"additional","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Zanaty","sequence":"additional","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"},{"name":"Urology Department, APHP, H\u00f4pital H. Mondor-A. Chenevier, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Lecointe","sequence":"additional","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"},{"name":"Plateforme Exploration Fonctionnelle du Petit Animal EPFA01 Mondor Institute, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Souktani","sequence":"additional","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"},{"name":"Plateforme Exploration Fonctionnelle du Petit Animal EPFA01 Mondor Institute, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Zadigue","sequence":"additional","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Figeac","sequence":"additional","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"INSERM U955 Team 12, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, UMR_S955, UPEC, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,23]]},"reference":[{"key":"2022010523342132800_stem2226-bib-0001","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.ejca.2012.11.030","article-title":"Cancer incidence and mortality patterns in South Eastern Europe in the last decade: Gaps persist compared with the rest of Europe","volume":"49","author":"Znaor","year":"2013","journal-title":"Eur J Cancer"},{"key":"2022010523342132800_stem2226-bib-0002","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","article-title":"Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012","volume":"49","author":"Ferlay","year":"2013","journal-title":"Eur J Cancer"},{"key":"2022010523342132800_stem2226-bib-0003","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.juro.2008.10.019","article-title":"Changes in continence and erectile function between 2 and 4 years after radical prostatectomy","volume":"181","author":"Glickman","year":"2009","journal-title":"J Urol"},{"key":"2022010523342132800_stem2226-bib-0004","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1089\/end.2010.0295","article-title":"Retropubic, laparoscopic, and robot-assisted radical prostatectomy: A critical review of outcomes reported by high-volume centers","volume":"24","author":"Coelho","year":"2010","journal-title":"J Endourol"},{"key":"2022010523342132800_stem2226-bib-0005","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0022-5347(17)53012-8","article-title":"Impotence following radical prostatectomy: Insight into etiology and prevention","volume":"128","author":"Walsh","year":"1982","journal-title":"J Urol"},{"issue":"pt 4","key":"2022010523342132800_stem2226-bib-0006","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1046\/j.1469-7580.1999.19540605.x","article-title":"Supra and infralevator neurovascular pathways to the penile corpora cavernosa","volume":"195","author":"Benoit","year":"1999","journal-title":"J Anat"},{"key":"2022010523342132800_stem2226-bib-0007","first-page":"91","article-title":"The hemodynamics of erectile dysfunction following nerve-sparing radical retropubic prostatectomy","volume":"8","author":"Mulhall","year":"1996","journal-title":"Int J Impot Res"},{"key":"2022010523342132800_stem2226-bib-0008","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1442-2042.2010.02632.x","article-title":"Upfront transection and subsequent ligation of the dorsal vein complex during laparoscopic radical prostatectomy","volume":"17","author":"Sasaki","year":"2010","journal-title":"Int J Urol"},{"key":"2022010523342132800_stem2226-bib-0009","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1089\/end.2010.0581","article-title":"Sphincter lesions after radical prostatectomy-evaluation and classification","volume":"25","author":"Gerullis","year":"2011","journal-title":"J Endourol"},{"key":"2022010523342132800_stem2226-bib-0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/00365598909180336","article-title":"A neurophysiological study of patients undergoing radical prostatectomy","volume":"23","author":"Hansen","year":"1989","journal-title":"Scand J Urol Nephrol"},{"key":"2022010523342132800_stem2226-bib-0011","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.eururo.2008.08.057","article-title":"Recovery of urinary continence after radical prostatectomy: Association with urethral length and urethral fibrosis measured by preoperative and postoperative endorectal magnetic resonance imaging","volume":"55","author":"Paparel","year":"2009","journal-title":"Eur Urol"},{"key":"2022010523342132800_stem2226-bib-0012","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.eururo.2011.03.020","article-title":"Contemporary management of postprostatectomy incontinence","volume":"59","author":"Bauer","year":"2011","journal-title":"Eur Urol"},{"key":"2022010523342132800_stem2226-bib-0013","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.purol.2009.09.019","article-title":"Management of erectile dysfunction after radical prostatectomy","volume":"19","author":"Droupy","year":"2009","journal-title":"Prog Urol"},{"key":"2022010523342132800_stem2226-bib-0014","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.juro.2013.06.084","article-title":"Combined inflatable penile prosthesis-artificial urinary sphincter implantation: No increased risk of adverse events compared to single or staged device implantation","volume":"190","author":"Segal","year":"2013","journal-title":"J Urol"},{"key":"2022010523342132800_stem2226-bib-0015","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1242\/jcs.01103","article-title":"Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential","volume":"117","author":"D'Ippolito","year":"2004","journal-title":"J Cell Sci"},{"key":"2022010523342132800_stem2226-bib-0016","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1084\/jem.20042224","article-title":"Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse","volume":"201","author":"Rodriguez","year":"2005","journal-title":"J Exp Med"},{"key":"2022010523342132800_stem2226-bib-0017","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1182\/blood.V98.9.2615","article-title":"Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells","volume":"98","author":"Reyes","year":"2001","journal-title":"Blood"},{"key":"2022010523342132800_stem2226-bib-0018","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1097\/01.ju.0000176489.96993.84","article-title":"Processed lipoaspirate cells for tissue engineering of the lower urinary tract: Implications for the treatment of stress urinary incontinence and bladder reconstruction","volume":"174","author":"Jack","year":"2005","journal-title":"J Urol"},{"key":"2022010523342132800_stem2226-bib-0019","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/nau.20998","article-title":"Bone marrow mesenchymal stromal cell therapy for external urethral sphincter restoration in a rat model of stress urinary incontinence","volume":"30","author":"Corcos","year":"2011","journal-title":"Neurourol Urodyn"},{"key":"2022010523342132800_stem2226-bib-0020","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/01.TP.0000090396.71097.C2","article-title":"Restoration of functional motor units in a rat model of sphincter injury by muscle precursor cell autografts","volume":"76","author":"Yiou","year":"2003","journal-title":"Transplantation"},{"key":"2022010523342132800_stem2226-bib-0021","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.eururo.2011.07.061","article-title":"Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury","volume":"61","author":"Fandel","year":"2012","journal-title":"Eur Urol"},{"key":"2022010523342132800_stem2226-bib-0022","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.eururo.2008.09.059","article-title":"Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction","volume":"56","author":"Fall","year":"2009","journal-title":"Eur Urol"},{"key":"2022010523342132800_stem2226-bib-0023","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00192-010-1255-5","article-title":"Intrasphincteric injections of autologous muscular cells in women with refractory stress urinary incontinence: A prospective study","volume":"22","author":"Sebe","year":"2011","journal-title":"Int Urogynecol J"},{"key":"2022010523342132800_stem2226-bib-0024","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/iju.12266","article-title":"Regenerative treatment of male stress urinary incontinence by periurethral injection of autologous adipose-derived regenerative cells: 1-year outcomes in 11 patients","volume":"21","author":"Gotoh","year":"2014","journal-title":"Int J Urol"},{"key":"2022010523342132800_stem2226-bib-0025","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0090-4295(98)00128-9","article-title":"Preservation of putative continence nerves during radical retropubic prostatectomy leads to more rapid return of urinary continence","volume":"51","author":"Hollabaugh","year":"1998","journal-title":"Urology"},{"key":"2022010523342132800_stem2226-bib-0026","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00345-014-1302-9","article-title":"Do we need the nerve sparing radical prostatectomy techniques (intrafascial vs. interfascial) in men with erectile dysfunction? Results of a single-centre study","volume":"33","author":"Khoder","year":"2015","journal-title":"World J Urol"},{"key":"2022010523342132800_stem2226-bib-0027","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1464-410X.2012.11315.x","article-title":"Nerve-sparing approach during radical prostatectomy is strongly associated with the rate of postoperative urinary continence recovery","volume":"111","author":"Suardi","year":"2013","journal-title":"BJU Int"},{"key":"2022010523342132800_stem2226-bib-0028","first-page":"1","article-title":"Adult mesenchymal stem cells and their potency in the cell-based therapy","volume":"8","author":"Das","year":"2013","journal-title":"Stem Cells"},{"key":"2022010523342132800_stem2226-bib-0029","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1038\/emm.2013.94","article-title":"Mesenchymal Stem Cells: Environmentally responsive therapeutics for regenerative medicine","volume":"45","author":"Murphy","year":"2013","journal-title":"Exp Mol Med"},{"key":"2022010523342132800_stem2226-bib-0030","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3727\/096368913X670921","article-title":"Rat mesenchymal stem cell secretome promotes elastogenesis and facilitates recovery from simulated childbirth injury","volume":"23","author":"Dissaranan","year":"2014","journal-title":"Cell Transplant"},{"key":"2022010523342132800_stem2226-bib-0031","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1111\/j.1743-6109.2010.01875.x","article-title":"Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury","volume":"7","author":"Albersen","year":"2010","journal-title":"J Sex Med"},{"key":"2022010523342132800_stem2226-bib-0032","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1365-2605.2012.01250.x","article-title":"Neurotrophic effect of bone marrow mesenchymal stem cells for erectile dysfunction in diabetic rats","volume":"35","author":"Sun","year":"2012","journal-title":"Int J Androl"},{"key":"2022010523342132800_stem2226-bib-0033","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1111\/j.1743-6109.2012.02905.x","article-title":"Monitoring of erectile and urethral sphincter dysfunctions in a rat model mimicking radical prostatectomy damage","volume":"9","author":"Khodari","year":"2012","journal-title":"J Sex Med"},{"key":"2022010523342132800_stem2226-bib-0034","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.eururo.2012.05.046","article-title":"Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy","volume":"62","author":"Ficarra","year":"2012","journal-title":"Eur Urol"},{"key":"2022010523342132800_stem2226-bib-0035","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/stem.1560","article-title":"Nanotubular crosstalk with distressed cardiomyocytes stimulates the paracrine repair function of mesenchymal stem cells","volume":"32","author":"Figeac","year":"2014","journal-title":"Stem Cells"},{"key":"2022010523342132800_stem2226-bib-0036","first-page":"1242","article-title":"Pericytes in the myovascular niche promote post-natal myofiber growth and satellite cell quiescence","volume":"142","author":"Kostallari","year":"2015","journal-title":"Development"},{"issue":"pt 3","key":"2022010523342132800_stem2226-bib-0037","first-page":"677","article-title":"Type-specific changes in fibre size and satellite cell activation following muscle denervation in two strains of turkey (Meleagris gallopavo)","volume":"188","author":"Bakou","year":"1996","journal-title":"J Anat"},{"key":"2022010523342132800_stem2226-bib-0038","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1464-410X.2009.08775.x","article-title":"The timing of penile rehabilitation after bilateral nerve-sparing radical prostatectomy affects the recovery of erectile function","volume":"105","author":"Mulhall","year":"2010","journal-title":"BJU Int"},{"key":"2022010523342132800_stem2226-bib-0039","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.eururo.2012.04.046","article-title":"Prevention and management of postprostatectomy sexual dysfunctions. Part 1: Choosing the right patient at the right time for the right surgery","volume":"62","author":"Salonia","year":"2012","journal-title":"Eur Urol"},{"key":"2022010523342132800_stem2226-bib-0040","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1089\/scd.2012.0176","article-title":"Allogeneic and xenogeneic transplantation of adipose-derived stem cells in immunocompetent recipients without immunosuppressants","volume":"21","author":"Lin","year":"2012","journal-title":"Stem Cells Dev"},{"key":"2022010523342132800_stem2226-bib-0041","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3892\/mmr.2014.2502","article-title":"Effect of bone marrow stromal cell transplantation on neurologic function and expression of VEGF in rats with focal cerebral ischemia","volume":"10","author":"Li","year":"2014","journal-title":"Mol Med Rep"},{"key":"2022010523342132800_stem2226-bib-0042","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1634\/stemcells.2005-0046","article-title":"Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells","volume":"24","author":"Ma","year":"2006","journal-title":"Stem Cells"},{"key":"2022010523342132800_stem2226-bib-0043","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.msea.2012.04.037","article-title":"Adipose-derived mesenchymal stem cells ameliorate STZ-induced pancreas damage in type 1 diabetes","volume":"22","author":"Li","year":"2012","journal-title":"Biomed Mater Eng"},{"key":"2022010523342132800_stem2226-bib-0044","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2796.2007.01844.x","article-title":"Immunomodulation by mesenchymal stem cells and clinical experience","volume":"262","author":"Blanc","year":"2007","journal-title":"J Intern Med"},{"key":"2022010523342132800_stem2226-bib-0045","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.eururo.2011.07.061","article-title":"Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury","volume":"61","author":"Fandel","year":"2012","journal-title":"Eur Urol"},{"key":"2022010523342132800_stem2226-bib-0046","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1442-2042.2010.02471.x","article-title":"Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter","volume":"17","author":"Kinebuchi","year":"2010","journal-title":"Int J Urol"},{"key":"2022010523342132800_stem2226-bib-0047","doi-asserted-by":"crossref","first-page":"e45538","DOI":"10.1371\/journal.pone.0045538","article-title":"Myogenic potential of whole bone marrow mesenchymal stem cells in vitro and in vivo for usage in urinary incontinence","volume":"7","author":"Gunetti","year":"2012","journal-title":"PLoS One"},{"key":"2022010523342132800_stem2226-bib-0048","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1741-7015-10-94","article-title":"Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model","volume":"10","author":"Kim","year":"2012","journal-title":"BMC Med"},{"key":"2022010523342132800_stem2226-bib-0049","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.urology.2012.08.046","article-title":"Periprostatic implantation of human bone marrow-derived mesenchymal stem cells potentiates recovery of erectile function by intracavernosal injection in a rat model of cavernous nerve injury","volume":"81","author":"You","year":"2013","journal-title":"Urology"},{"key":"2022010523342132800_stem2226-bib-0050","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1743-6109.2010.02118.x","article-title":"Intracavernous transplantation of bone marrow-derived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats","volume":"8","author":"Qiu","year":"2011","journal-title":"J Sex Med"},{"key":"2022010523342132800_stem2226-bib-0051","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000317322","article-title":"Bone-marrow-derived mesenchymal stem cell transplantation enhances closing pressure and leak point pressure in a female urinary incontinence rat model","volume":"86","author":"Kim","year":"2011","journal-title":"Urol Int"},{"key":"2022010523342132800_stem2226-bib-0052","doi-asserted-by":"crossref","first-page":"e15652","DOI":"10.1371\/journal.pone.0015652","article-title":"Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration","volume":"6","author":"Gaebel","year":"2011","journal-title":"PLoS One"},{"key":"2022010523342132800_stem2226-bib-0053","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4252\/wjsc.v5.i4.112","article-title":"Regenerative medicine based applications to combat stress urinary incontinence","volume":"5","author":"Thaker","year":"2013","journal-title":"World J Stem Cells"},{"key":"2022010523342132800_stem2226-bib-0054","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.urology.2012.05.030","article-title":"Activation of VEGF and ERK1\/2 and improvement of urethral function by adipose-derived stem cells in a rat stress urinary incontinence model","volume":"80","author":"Li","year":"2012","journal-title":"Urology"},{"key":"2022010523342132800_stem2226-bib-0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/j.1939-4640.2003.tb02645.x","article-title":"Ex vivo expression of angiogenic growth factors and their receptors in human penile cavernosal cells","volume":"24","author":"Rajasekaran","year":"2003","journal-title":"J Androl"},{"key":"2022010523342132800_stem2226-bib-0056","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/nau.20748","article-title":"The effects of hepatocyte growth factor and insulin-like growth factor-1 on the myogenic differentiation of satellite cells in human urethral rhabdosphincter","volume":"29","author":"Sumino","year":"2010","journal-title":"Neurourol Urodyn"},{"key":"2022010523342132800_stem2226-bib-0057","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/aja.2011.161","article-title":"Mobilisation of endothelial progenitor cells: One of the possible mechanisms involved in the chronic administration of melatonin preventing erectile dysfunction in diabetic rats","volume":"14","author":"Qiu","year":"2012","journal-title":"Asian J Androl"},{"key":"2022010523342132800_stem2226-bib-0058","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1074\/jbc.M113.537597","article-title":"Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion","volume":"289","author":"Ziegler","year":"2014","journal-title":"J Biol Chem"},{"key":"2022010523342132800_stem2226-bib-0059","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.juro.2013.08.109","article-title":"Therapeutic effects of IGF-1 on stress urinary incontinence in rats with simulated childbirth trauma","volume":"191","author":"Sumino","year":"2014","journal-title":"J Urol"},{"key":"2022010523342132800_stem2226-bib-0060","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.3727\/096368911X623835","article-title":"Muscle precursor cells for the restoration of irreversibly damaged sphincter function","volume":"21","author":"Eberli","year":"2012","journal-title":"Cell Transplant"},{"key":"2022010523342132800_stem2226-bib-0061","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1464-410X.2012.11682.x","article-title":"Periurethral skeletal myofibre implantation in patients with urinary incontinence and intrinsic sphincter deficiency: A phase I clinical trial","volume":"111","author":"Yiou","year":"2013","journal-title":"BJU Int"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.2226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.2226","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.2226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.2226","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/34\/2\/392\/42047615\/stmcls_34_2_392.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/34\/2\/392\/42047615\/stmcls_34_2_392.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T22:47:47Z","timestamp":1748645267000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/34\/2\/392-404\/6407515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,23]]},"references-count":61,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,10,23]]},"published-print":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.2226","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,2,1]]},"published":{"date-parts":[[2015,10,23]]}}}