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The carotid body (CB) contains a population of peripheral NSCs, which support organ growth during acclimatization to hypoxia. We have set up CB neurosphere (NS) cultures enriched in differentiated neuronal (glomus) cells versus undifferentiated progenitors to investigate molecular hallmarks of cell classes within the CB stem cell (CBSC) niche. Microarray gene expression analysis in NS is compatible with CBSCs being neural crest derived-multipotent progenitor cells able to sustain CB growth upon exposure to hypoxia. Moreover, we have identified CD10 as a marker suitable for isolation of a population of CB mesectoderm-committed progenitor cells. CD10\u2009+\u2009cells are resting in normoxia, and during hypoxia they are activated to proliferate and to eventually complete maturation into mesectodermal cells, thus participating in the angiogenesis necessary for CB growth. Our results shed light into the molecular and cellular mechanisms involved in CBSC fate choice, favoring a potential use of these cells for cell therapy.<\/jats:p>","DOI":"10.1002\/stem.2331","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T13:52:05Z","timestamp":1455198725000},"page":"1637-1650","source":"Crossref","is-referenced-by-count":23,"title":["Gene Expression Profiling Supports the Neural Crest Origin of Adult Rodent Carotid Body Stem Cells and Identifies CD10 as a Marker for Mesectoderm-Committed Progenitors"],"prefix":"10.1093","volume":"34","author":[{"given":"Elena","family":"Navarro-Guerrero","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Platero-Luengo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Linares-Clemente","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildefonso","family":"Cases","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology Group. 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