{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:45:35Z","timestamp":1768473935974,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":1965,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Strategic Priority Research Program","award":["XDA01020106"],"award-info":[{"award-number":["XDA01020106"]}]},{"name":"Hong Kong Research Grant Council","award":["Theme Based Research Scheme (T12-705\/11 to HFT)"],"award-info":[{"award-number":["Theme Based Research Scheme (T12-705\/11 to HFT)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent pre-clinical and clinical studies have suggested that endogenous cardiospheres (eCS) are potentially safe and effective for cardiac regeneration following myocardial infarction (MI). Nevertheless the preparation of autologous eCS requires invasive myocardial biopsy with limited yield. We describe a novel approach to generate induced cardiospheres (iCS) from adult skin fibroblasts via somatic reprogramming. After infection with Sox2, Klf4, and Oct4, iCS were generated from mouse adult skin fibroblasts treated with Gsk3\u03b2 inhibitor-(2\u2032Z,3\u2032E)- 6-Bromoindirubin-3\u2032-oxime and Oncostatin M. They resembled eCS, but contained a higher percentage of cells expressing Mesp1, Isl1, and Nkx2.5. They were differentiated into functional cardiomyocytes in vitro with similar electrophysiological properties, calcium transient and contractile function to eCS and mouse embryonic stem cell-derived cardiomyocytes. Transplantation of iCS (1 \u00d7 106 cells) into mouse myocardium following MI had similar effects to transplantation of eCS but significantly better than saline or fibroblast in improving left ventricular ejection fraction, increasing anterior\/septal ventricular wall thickness and capillary density in the infarcted region 4 weeks after transplantation. No tumor formation was observed. iCS generated from adult skin fibroblasts by somatic reprogramming and a cocktail of Gsk3\u03b2 inhibitor-6-Bromoindirubin-3\u2032-oxime and Oncostatin M may represent a novel source for cell therapy in MI.<\/jats:p>","DOI":"10.1002\/stem.2438","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T01:23:04Z","timestamp":1466644984000},"page":"2693-2706","source":"Crossref","is-referenced-by-count":33,"title":["Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration"],"prefix":"10.1093","volume":"34","author":[{"given":"Jian-Yong","family":"Xu","sequence":"first","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"},{"name":"Shenzhen Institutes of Research and Innovation, the University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee-Ki","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinru","family":"Ran","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-Yan","family":"Liao","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"},{"name":"Shenzhen Institutes of Research and Innovation, the University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka-Wing","family":"Au","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing-Hon","family":"Lai","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Esteban","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"},{"name":"Hong Kong-Guangdong Joint Laboratory on Stem Cell and Regenerative Medicine, The University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, China"},{"name":"Laboratory of Chromatin and Human Disease, Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Fat","family":"Tse","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China"},{"name":"Shenzhen Institutes of Research and Innovation, the University of Hong Kong, Hong Kong, SAR, China"},{"name":"Hong Kong-Guangdong Joint Laboratory on Stem Cell and Regenerative Medicine, The University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, China"},{"name":"Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"2022010901435239100_stem2438-bib-0001","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"2022010901435239100_stem2438-bib-0002","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the global burden of disease study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"2022010901435239100_stem2438-bib-0003","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/01.CIR.103.5.634","article-title":"Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia","volume":"103","author":"Kawamoto","year":"2001","journal-title":"Circulation"},{"key":"2022010901435239100_stem2438-bib-0004","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(12)60236-0","article-title":"Cardiac regeneration: Messages from CADUCEUS","volume":"379","author":"Siu","year":"2012","journal-title":"Lancet"},{"key":"2022010901435239100_stem2438-bib-0005","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/CIRCRESAHA.113.300219","article-title":"Cell therapy for heart failure: A comprehensive overview of experimental and clinical studies, current challenges, and future directions","volume":"113","author":"Sanganalmath","year":"2013","journal-title":"Circ Res"},{"key":"2022010901435239100_stem2438-bib-0006","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ejheart.2007.03.008","article-title":"Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium","volume":"9","author":"Tse","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2022010901435239100_stem2438-bib-0007","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1172\/JCI27019","article-title":"Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines","volume":"116","author":"Fazel","year":"2006","journal-title":"J Clin Invest"},{"key":"2022010901435239100_stem2438-bib-0008","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.RES.0000147315.71699.51","article-title":"Isolation and expansion of adult cardiac stem cells from human and murine heart","volume":"95","author":"Messina","year":"2004","journal-title":"Circ Res"},{"key":"2022010901435239100_stem2438-bib-0009","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCULATIONAHA.106.655209","article-title":"Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens","volume":"115","author":"Smith","year":"2007","journal-title":"Circulation"},{"key":"2022010901435239100_stem2438-bib-0010","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","article-title":"Adult cardiac stem cells are multipotent and support myocardial regeneration","volume":"114","author":"Beltrami","year":"2003","journal-title":"Cell"},{"key":"2022010901435239100_stem2438-bib-0011","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.devcel.2006.10.002","article-title":"Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages","volume":"11","author":"Kattman","year":"2006","journal-title":"Dev Cell"},{"key":"2022010901435239100_stem2438-bib-0012","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature07060","article-title":"Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart","volume":"454","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"2022010901435239100_stem2438-bib-0013","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.stem.2008.06.009","article-title":"Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification","volume":"3","author":"Bondue","year":"2008","journal-title":"Cell Stem Cell"},{"key":"2022010901435239100_stem2438-bib-0014","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai","year":"2003","journal-title":"Dev Cell"},{"key":"2022010901435239100_stem2438-bib-0015","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.cell.2006.10.028","article-title":"Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart","volume":"127","author":"Wu","year":"2006","journal-title":"Cell"},{"key":"2022010901435239100_stem2438-bib-0016","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1083\/jcb.200603014","article-title":"Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo","volume":"176","author":"Oyama","year":"2007","journal-title":"J Cell Biol"},{"key":"2022010901435239100_stem2438-bib-0017","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.RES.0000150856.47324.5b","article-title":"Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction","volume":"95","author":"Kucia","year":"2004","journal-title":"Circ Res"},{"key":"2022010901435239100_stem2438-bib-0018","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/CIRCRESAHA.115.306850","article-title":"Comparative efficacy of intracoronary allogeneic mesenchymal stem cells and cardiosphere-derived cells in swine with hibernating myocardium","volume":"117","author":"Weil","year":"2015","journal-title":"Circ Res"},{"key":"2022010901435239100_stem2438-bib-0019","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/CIRCULATIONAHA.110.971622","article-title":"Characterization and functionality of cardiac progenitor cells in congenital heart patients","volume":"123","author":"Mishra","year":"2011","journal-title":"Circulation"},{"key":"2022010901435239100_stem2438-bib-0020","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.116.304671","article-title":"Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome (TICAP): A prospective phase 1 controlled Trial","volume":"116","author":"Ishigami","year":"2013","journal-title":"Circ Res"},{"key":"2022010901435239100_stem2438-bib-0021","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/eurheartj\/ehu192","article-title":"Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: A translational experience","volume":"36","author":"Menasche","year":"2015","journal-title":"Eur Heart J"},{"key":"2022010901435239100_stem2438-bib-0022","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ncb2164","article-title":"Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy","volume":"13","author":"Efe","year":"2011","journal-title":"Nat Cell Biol"},{"key":"2022010901435239100_stem2438-bib-0023","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.celrep.2014.01.038","article-title":"Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4","volume":"6","author":"Wang","year":"2014","journal-title":"Cell Rep"},{"key":"2022010901435239100_stem2438-bib-0024","doi-asserted-by":"crossref","DOI":"10.3791\/51357-v","article-title":"Isolation and culture of adult mouse cardiomyocytes for cell signaling and in vitro cardiac hypertrophy","author":"Li","year":"2014","journal-title":"J Vis Exp"},{"key":"2022010901435239100_stem2438-bib-0025","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"2022010901435239100_stem2438-bib-0026","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1128\/jvi.70.8.5701-5705.1996","article-title":"The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses","volume":"70","author":"Naviaux","year":"1996","journal-title":"J Virol"},{"key":"2022010901435239100_stem2438-bib-0027","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1096\/fj.08-128546","article-title":"Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro","volume":"23","author":"Kuzmenkin","year":"2009","journal-title":"FASEB J"},{"key":"2022010901435239100_stem2438-bib-0028","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.33549\/physiolres.932000","article-title":"Measurement of cellular excitability by whole cell patch clamp technique","volume":"59","author":"Karmazinova","year":"2010","journal-title":"Physiol Res"},{"key":"2022010901435239100_stem2438-bib-0029","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-60761-950-5_12","article-title":"Imaging calcium sparks in cardiac myocytes","volume":"689","author":"Guatimosim","year":"2011","journal-title":"Methods Mol Biol"},{"key":"2022010901435239100_stem2438-bib-0030","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00424-013-1414-x","article-title":"Modeling of friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells","volume":"466","author":"Lee","year":"2014","journal-title":"Pflugers Arch"},{"key":"2022010901435239100_stem2438-bib-0031","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s12015-011-9273-3","article-title":"Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes","volume":"7","author":"Lee","year":"2011","journal-title":"Stem Cell Rev"},{"key":"2022010901435239100_stem2438-bib-0032","doi-asserted-by":"crossref","first-page":"e19787","DOI":"10.1371\/journal.pone.0019787","article-title":"Exogenous expression of human apoA-I enhances cardiac differentiation of pluripotent stem Cells","volume":"6","author":"Ng","year":"2011","journal-title":"Plos One"},{"key":"2022010901435239100_stem2438-bib-0033","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/toxsci\/kfu312","article-title":"Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes","volume":"144","author":"Pointon","year":"2015","journal-title":"Toxicol Sci"},{"key":"2022010901435239100_stem2438-bib-0034","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open source clustering software","volume":"20","author":"de Hoon","year":"2004","journal-title":"Bioinformatics"},{"key":"2022010901435239100_stem2438-bib-0035","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.hrthm.2010.09.006","article-title":"Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium","volume":"7","author":"Liao","year":"2010","journal-title":"Heart Rhythm"},{"key":"2022010901435239100_stem2438-bib-0036","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/nprot.2008.138","article-title":"Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats","volume":"3","author":"Pacher","year":"2008","journal-title":"Nat Protoc"},{"key":"2022010901435239100_stem2438-bib-0037","doi-asserted-by":"crossref","first-page":"31066","DOI":"10.1074\/jbc.M110.139436","article-title":"Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells","volume":"285","author":"Chen","year":"2010","journal-title":"J Biol Chem"},{"key":"2022010901435239100_stem2438-bib-0038","doi-asserted-by":"crossref","first-page":"10894","DOI":"10.1073\/pnas.0704044104","article-title":"Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors","volume":"104","author":"Kwon","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022010901435239100_stem2438-bib-0039","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.stem.2007.05.018","article-title":"The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt\/beta-catenin pathway","volume":"1","author":"Qyang","year":"2007","journal-title":"Cell Stem Cell"},{"key":"2022010901435239100_stem2438-bib-0040","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1161\/CIRCULATIONAHA.111.084699","article-title":"A strong regenerative ability of cardiac stem cells derived from neonatal hearts","volume":"126","author":"Simpson","year":"2012","journal-title":"Circulation"},{"key":"2022010901435239100_stem2438-bib-0041","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/01.RES.0000117306.10142.50","article-title":"Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression","volume":"94","author":"Torella","year":"2004","journal-title":"Circ Res"},{"key":"2022010901435239100_stem2438-bib-0042","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/CIRCRESAHA.110.221531","article-title":"The multiple phases and faces of Wnt signaling during cardiac differentiation and development","volume":"107","author":"Gessert","year":"2010","journal-title":"Circ Res"},{"key":"2022010901435239100_stem2438-bib-0043","doi-asserted-by":"crossref","first-page":"9313","DOI":"10.1073\/pnas.0700923104","article-title":"Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis","volume":"104","author":"Lin","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022010901435239100_stem2438-bib-0044","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1172\/JCI31731","article-title":"Wnt\/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling","volume":"117","author":"Cohen","year":"2007","journal-title":"J Clin Invest"},{"key":"2022010901435239100_stem2438-bib-0045","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.stem.2011.08.013","article-title":"Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling","volume":"9","author":"Kubin","year":"2011","journal-title":"Cell Stem Cell"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.2438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.2438","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.2438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.2438","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/34\/11\/2693\/42027621\/stmcls_34_11_2693.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/34\/11\/2693\/42027621\/stmcls_34_11_2693.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:03:23Z","timestamp":1692403403000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/34\/11\/2693-2706\/6408391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,7,7]]},"published-print":{"date-parts":[[2016,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.2438","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,11,1]]},"published":{"date-parts":[[2016,7,7]]}}}