{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:34:45Z","timestamp":1791117285435,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":1865,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000163","name":"ARC","doi-asserted-by":"publisher","award":["SFI2011205489"],"award-info":[{"award-number":["SFI2011205489"]}],"id":[{"id":"10.13039\/100000163","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Plan Nacional","award":["RTA2012-00004 and AGL2012-37988-C04"],"award-info":[{"award-number":["RTA2012-00004 and AGL2012-37988-C04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The prion protein is infamous for its involvement in a group of neurodegenerative diseases known as Transmissible Spongiform Encephalopathies. In the longstanding quest to decipher the physiological function of its cellular isoform, PrPC, the discovery of its participation to the self-renewal of hematopoietic and neural stem cells has cast a new spotlight on its potential role in stem cell biology. However, still little is known on the cellular and molecular mechanisms at play. Here, by combining in vitro and in vivo murine models of PrPC depletion, we establish that PrPC deficiency severely affects the Notch pathway, which plays a major role in neural stem cell maintenance. We document that the absence of PrPC in a neuroepithelial cell line or in primary neurospheres is associated with drastically reduced expression of Notch ligands and receptors, resulting in decreased levels of Notch target genes. Similar alterations of the Notch pathway are recovered in the neuroepithelium of Prnp\u2212\/\u2212 embryos during a developmental window encompassing neural tube closure. In addition, in line with Notch defects, our data show that the absence of PrPC results in altered expression of Nestin and Olig2 as well as N-cadherin distribution. We further provide evidence that PrPC controls the expression of the epidermal growth factor receptor (EGFR) downstream from Notch. Finally, we unveil a negative feedback action of EGFR on both Notch and PrPC. As a whole, our study delineates a molecular scenario through which PrPC takes part to the self-renewal of neural stem and progenitor cells.<\/jats:p>","DOI":"10.1002\/stem.2501","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T08:51:35Z","timestamp":1474275095000},"page":"754-765","source":"Crossref","is-referenced-by-count":37,"title":["The Cellular Prion Protein Controls Notch Signaling in Neural Stem\/Progenitor Cells"],"prefix":"10.1093","volume":"35","author":[{"given":"S\u00e9verine","family":"Martin-Lanner\u00e9e","sequence":"first","affiliation":[{"name":"a INSERM UMR 1124, Paris, France"},{"name":"b Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, UMR 1124, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Halliez","sequence":"additional","affiliation":[{"name":"c VIM, UR 892, INRA, Universit\u00e9 Paris-Saclay, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9o Z.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"a INSERM UMR 1124, Paris, France"},{"name":"b Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, UMR 1124, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hernandez-Rapp","sequence":"additional","affiliation":[{"name":"a INSERM UMR 1124, Paris, France"},{"name":"b Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, UMR 1124, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Passet","sequence":"additional","affiliation":[{"name":"d Department of Pharma Research, INRA UMR 1313, G\u00e9n\u00e9tique animale et biologie int\u00e9grative, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Tomkiewicz","sequence":"additional","affiliation":[{"name":"a INSERM UMR 1124, Paris, France"},{"name":"b Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, UMR 1124, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Villa-Diaz","sequence":"additional","affiliation":[{"name":"e Centro de Investigaci\u00f3n en Sanidad Animal-INIA, U 942 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Maria","family":"Torres","sequence":"additional","affiliation":[{"name":"e Centro de Investigaci\u00f3n en Sanidad Animal-INIA, U 942 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Launay","sequence":"additional","affiliation":[{"name":"f AP-HP Service de Biochimie, Fondation FondaMental, INSERM U942 H\u00f4pital Lariboisi\u00e8re, Paris, France"},{"name":"g Pharma Research Department, F. Hoffmann-La-Roche Ltd, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"B\u00e9ringue","sequence":"additional","affiliation":[{"name":"c VIM, UR 892, INRA, Universit\u00e9 Paris-Saclay, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Vilotte","sequence":"additional","affiliation":[{"name":"d Department of Pharma Research, INRA UMR 1313, G\u00e9n\u00e9tique animale et biologie int\u00e9grative, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Mouillet-Richard","sequence":"additional","affiliation":[{"name":"a INSERM UMR 1124, Paris, France"},{"name":"b Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, UMR 1124, Paris, 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