{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:55:27Z","timestamp":1791618927533,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,2,5]],"date-time":"2017-02-05T00:00:00Z","timestamp":1486252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mesenchymal stem cells (MSC) are multipotent cells able to differentiate into several cell types, hence providing cell reservoirs for therapeutic applications. The absence of detectable MSC homing at injury sites suggests that paracrine functions could, at least in part, be mediated by extracellular vesicles (EVs); EVs are newly identified players that are studied mainly as predictive or diagnostic biomarkers. Together with their clinical interests, EVs have recently come to the fore for their role in cell-to-cell communication. In this context, we investigated gene-based communication mechanisms in EVs generated by bone marrow and umbilical cord blood MSC (BMMSC and CBMSC, respectively). Both MSC types released vesicles with similar physical properties, although CBMSC were able to secrete EVs with faster kinetics. A pattern of preferentially incorporated EV transcripts was detected with respect to random internalization from the cytosol, after a validated normalization procedure was established. In the paradigm where EVs act as bioeffectors educating target cells, we demonstrated that kidney tubular cells lacking IL-10 expression and exposed to BMMSC-EVs and CBMSC-EVs acquired the IL-10 mRNA, which was efficiently translated into the corresponding protein. These findings suggest that horizontal mRNA transfer through EVs is a new mechanism in the MSC restoring ability observed in vivo that is here further demonstrated in an in vitro rescue model after acute cisplatin injury of tubular cells.<\/jats:p>","DOI":"10.1002\/stem.2557","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T03:23:23Z","timestamp":1486351403000},"page":"1093-1105","source":"Crossref","is-referenced-by-count":104,"title":["Extracellular Vesicle-Shuttled mRNA in Mesenchymal Stem Cell Communication"],"prefix":"10.1093","volume":"35","author":[{"given":"Enrico","family":"Ragni","sequence":"first","affiliation":[{"name":"a Cell Factory, Unit of Cell Therapy and Cryobiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Banfi","sequence":"additional","affiliation":[{"name":"a Cell Factory, Unit of Cell Therapy and Cryobiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Barilani","sequence":"additional","affiliation":[{"name":"a Cell Factory, Unit of Cell Therapy and Cryobiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"b Department of Industrial Engineering, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cherubini","sequence":"additional","affiliation":[{"name":"a Cell Factory, Unit of Cell Therapy and Cryobiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Parazzi","sequence":"additional","affiliation":[{"name":"a Cell Factory, Unit of Cell Therapy and Cryobiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Larghi","sequence":"additional","affiliation":[{"name":"c Autoimmunity Program, Istituto Nazionale di Genetica Molecolare \u201cRomeo Ed Enrica Invernizzi\u201d, Milan, Italy"},{"name":"d Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Dolo","sequence":"additional","affiliation":[{"name":"e Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bollati","sequence":"additional","affiliation":[{"name":"f EPIGET - Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy"},{"name":"g Epidemiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Lazzari","sequence":"additional","affiliation":[{"name":"a Cell Factory, Unit of Cell Therapy and Cryobiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,5]]},"reference":[{"key":"2022022509204513200_stem2557-bib-0001","doi-asserted-by":"crossref","first-page":"e00191","DOI":"10.1042\/BSR20150025","article-title":"Human mesenchymal stem cells - Current trends and future prospective","volume":"35","author":"Ullah","year":"2015","journal-title":"Biosci Rep"},{"key":"2022022509204513200_stem2557-bib-0002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4161\/org.7.2.16150","article-title":"Multilineage stem cells in the adult: A perivascular legacy?","volume":"7","author":"Crisan","year":"2011","journal-title":"Organogenesis"},{"key":"2022022509204513200_stem2557-bib-0003","doi-asserted-by":"crossref","first-page":"734731","DOI":"10.1155\/2015\/734731","article-title":"Stem cells and regenerative medicine: Myth or reality of the 21th century","volume":"2015","author":"Stoltz","year":"2015","journal-title":"Stem Cells Int"},{"key":"2022022509204513200_stem2557-bib-0004","doi-asserted-by":"crossref","first-page":"e2062","DOI":"10.1038\/cddis.2015.327","article-title":"Mesenchymal stem cells and immunomodulation: Current status and future prospects","volume":"7","author":"Gao","year":"2016","journal-title":"Cell Death Dis"},{"key":"2022022509204513200_stem2557-bib-0005","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jcyt.2015.10.011","article-title":"Mesenchymal stromal cells and immunomodulation: A gathering of regulatory immune cells","volume":"18","author":"Najar","year":"2016","journal-title":"Cytotherapy"},{"key":"2022022509204513200_stem2557-bib-0006","doi-asserted-by":"crossref","first-page":"e19569","DOI":"10.1371\/journal.pone.0019569","article-title":"Human bone marrow-derived stem cells acquire epithelial characteristics through fusion with gastrointestinal epithelial cells","volume":"6","author":"Ferrand","year":"2011","journal-title":"PLoS One"},{"key":"2022022509204513200_stem2557-bib-0007","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1073\/pnas.0437997100","article-title":"Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma","volume":"100","author":"Spees","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022022509204513200_stem2557-bib-0008","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nature01539","article-title":"Transplanted bone marrow regenerates liver by cell fusion","volume":"422","author":"Vassilopoulos","year":"2003","journal-title":"Nature"},{"key":"2022022509204513200_stem2557-bib-0009","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/01.tp.0000214462.63943.14","article-title":"Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease","volume":"81","author":"Ringd\u00e9n","year":"2006","journal-title":"Transplantation"},{"key":"2022022509204513200_stem2557-bib-0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSC improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6","volume":"5","author":"Lee","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2022022509204513200_stem2557-bib-0011","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev-bioeng-070909-105309","article-title":"Mesenchymal stem cells as therapeutics","volume":"12","author":"Parekkadan","year":"2010","journal-title":"Annu Rev Biomed Eng"},{"key":"2022022509204513200_stem2557-bib-0012","doi-asserted-by":"crossref","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"2022022509204513200_stem2557-bib-0013","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/mt.2015.44","article-title":"Mesenchymal stem cell-derived extracellular vesicles: Toward cell-free therapeutic applications","volume":"5","author":"Rani","year":"2015","journal-title":"Mol Ther"},{"key":"2022022509204513200_stem2557-bib-0014","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.3390\/ijms15034142","article-title":"Exosomes derived from mesenchymal stem cells","volume":"15","author":"Yu","year":"2014","journal-title":"Int J Mol Sci"},{"key":"2022022509204513200_stem2557-bib-0015","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00018-015-2007-y","article-title":"Protein O-mannosylation is crucial for human mesencyhmal stem cells fate","volume":"73","author":"Ragni","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"2022022509204513200_stem2557-bib-0016","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"2022022509204513200_stem2557-bib-0017","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1582-4934.2012.01660.x","article-title":"What is beyond a qRT-PCR study on mesenchymal stem cell differentiation properties: How to choose the most reliable housekeeping genes","volume":"17","author":"Ragni","year":"2013","journal-title":"J Cell Mol Med"},{"key":"2022022509204513200_stem2557-bib-0018","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1046\/j.1523-1755.2001.00043.x","article-title":"Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury","volume":"60","author":"Deng","year":"2001","journal-title":"Kidney Int"},{"key":"2022022509204513200_stem2557-bib-0019","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1681\/ASN.2005030297","article-title":"IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease","volume":"16","author":"Mu","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2022022509204513200_stem2557-bib-0020","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1182\/blood-2007-03-078709","article-title":"Endothelial progenitor cell-derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA","volume":"110","author":"Deregibus","year":"2007","journal-title":"Blood"},{"key":"2022022509204513200_stem2557-bib-0021","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"2022022509204513200_stem2557-bib-0022","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"2022022509204513200_stem2557-bib-0023","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1681\/ASN.2008070798","article-title":"Mesenchymal stem cell-derived microvesicles protect against acute tubular injury","volume":"20","author":"Bruno","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"2022022509204513200_stem2557-bib-0024","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/stem.1504","article-title":"Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice","volume":"32","author":"Zhu","year":"2014","journal-title":"Stem Cells"},{"key":"2022022509204513200_stem2557-bib-0025","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"2022022509204513200_stem2557-bib-0026","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-1-61779-427-8_18","article-title":"miRNA expression profiling: From reference genes to global mean normalization","volume":"822","author":"D'haene","year":"2012","journal-title":"Methods Mol Biol"},{"key":"2022022509204513200_stem2557-bib-0027","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1038\/mtna.2011.2","article-title":"miR-1289 and \u201czipcode\u201d-like sequence enrich mRNAs in microvesicles","volume":"1","author":"Bolukbasi","year":"2012","journal-title":"Mol Ther Nucleic Acids"},{"key":"2022022509204513200_stem2557-bib-0028","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1186\/1471-2164-12-S3-S18","article-title":"Identification of nucleotide patterns enriched in secreted RNAs as putative cis-acting elements targeting them to exosome nano-vesicles","volume":"12","author":"Batagov","year":"2011","journal-title":"BMC Genomics"},{"key":"2022022509204513200_stem2557-bib-0029","doi-asserted-by":"crossref","first-page":"23377","DOI":"10.3390\/ijms151223377","article-title":"RNA recognition and stress granule formation by TIA proteins","volume":"15","author":"Waris","year":"2014","journal-title":"Int J Mol Sci"},{"key":"2022022509204513200_stem2557-bib-0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1745-6150-8-12","article-title":"Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3'-untranslated regions","volume":"8","author":"Batagov","year":"2013","journal-title":"Biol Direct"},{"key":"2022022509204513200_stem2557-bib-0031","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-4939-1062-5_26","article-title":"A schematic workflow for collecting information about the interaction between copy number variants and microRNAs using existing resources","volume":"1182","author":"Dweep","year":"2014","journal-title":"Methods Mol Biol"},{"key":"2022022509204513200_stem2557-bib-0032","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/stem.293","article-title":"Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury","volume":"28","author":"Morigi","year":"2010","journal-title":"Stem Cells"},{"key":"2022022509204513200_stem2557-bib-0033","doi-asserted-by":"crossref","first-page":"F362","DOI":"10.1152\/ajprenal.00579.2015","article-title":"Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice","volume":"311","author":"Soranno","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"2022022509204513200_stem2557-bib-0034","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2217\/BMM.15.45","article-title":"Extracellular vesicle microRNAs: Biomarker discovery in various diseases based on RT-qPCR","volume":"9","author":"Liu","year":"2015","journal-title":"Biomark Med"},{"key":"2022022509204513200_stem2557-bib-0035","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/cas.12896","article-title":"Extracellular vesicle transfer of cancer pathogenic components","volume":"107","author":"Fujita","year":"2016","journal-title":"Cancer Sci"},{"key":"2022022509204513200_stem2557-bib-0036","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13287-015-0150-x","article-title":"Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming","volume":"6","author":"Quesenberry","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"2022022509204513200_stem2557-bib-0037","doi-asserted-by":"crossref","first-page":"1073140","DOI":"10.1155\/2016\/1073140","article-title":"Extracellular vesicles: Evolving factors in stem cell biology","author":"Nawaz","year":"2016","journal-title":"Stem Cells Int"},{"key":"2022022509204513200_stem2557-bib-0038","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1161\/CIRCULATIONAHA.112.114173","article-title":"Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension","volume":"126","author":"Lee","year":"2012","journal-title":"Circulation"},{"key":"2022022509204513200_stem2557-bib-0039","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1089\/scd.2012.0395","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis","volume":"22","author":"Li","year":"2013","journal-title":"Stem Cells Dev"},{"key":"2022022509204513200_stem2557-bib-0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/scrt465","article-title":"Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models","volume":"5","author":"Tan","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"2022022509204513200_stem2557-bib-0041","doi-asserted-by":"crossref","first-page":"21927","DOI":"10.3402\/jev.v2i0.21927","article-title":"Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning","volume":"2","author":"Kilpinen","year":"2013","journal-title":"J Extracell Vesicles"},{"key":"2022022509204513200_stem2557-bib-0042","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/jcb.23042","article-title":"Isolation and characterization of mesenchymal stem cells from human umbilical cord blood: Reevaluation of critical factors for successful isolation and high ability to proliferate and differentiate to chondrocytes as compared to mesenchymal stem cells from bone marrow and adipose tissue","volume":"112","author":"Zhang","year":"2011","journal-title":"J Cell Biochem"},{"key":"2022022509204513200_stem2557-bib-0043","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1089\/scd.2014.0160","article-title":"Dissection of the cord blood stromal component reveals predictive parameters for culture outcome","volume":"24","author":"Barilani","year":"2015","journal-title":"Stem Cells Dev"},{"key":"2022022509204513200_stem2557-bib-0044","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.30.1_supplement.160.2","article-title":"Extracellular vesicles isolated from human mesenchymal stem cells promote resolution of pulmonary fibrosis","volume":"30","author":"Shentu","year":"2016","journal-title":"FASEB J"},{"key":"2022022509204513200_stem2557-bib-0045","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/nar\/gkp857","article-title":"Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs","volume":"1","author":"Chen","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"2022022509204513200_stem2557-bib-0046","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3892\/ijmm.2016.2488","article-title":"Role of Alix in miRNA packaging during extracellular vesicle biogenesis","volume":"37","author":"Iavello","year":"2016","journal-title":"Int J Mol Med"},{"key":"2022022509204513200_stem2557-bib-0047","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/labinvest.2013.64","article-title":"Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model","volume":"93","author":"Jin","year":"2013","journal-title":"Lab Invest"},{"key":"2022022509204513200_stem2557-bib-0048","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ndt\/gfs556","article-title":"Mesenchymal stem cells and kidney repair","volume":"28","author":"Morigi","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"2022022509204513200_stem2557-bib-0049","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1089\/scd.2012.0266","article-title":"Transfer of growth factor receptor mRNA via exosomes unravels the regenerative effect of mesenchymal stem cells","volume":"22","author":"Tomasoni","year":"2013","journal-title":"Stem Cells Dev"},{"key":"2022022509204513200_stem2557-bib-0050","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1042\/BST0320606","article-title":"Translation inhibition during the induction of apoptosis: RNA or protein degradation?","volume":"32","author":"Bushell","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"2022022509204513200_stem2557-bib-0051","doi-asserted-by":"crossref","first-page":"e33115","DOI":"10.1371\/journal.pone.0033115","article-title":"Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury","volume":"7","author":"Bruno","year":"2012","journal-title":"PLoS One"},{"key":"2022022509204513200_stem2557-bib-0052","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1002\/stem.1771","article-title":"HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing","volume":"33","author":"Zhang","year":"2015","journal-title":"Stem Cells"},{"key":"2022022509204513200_stem2557-bib-0053","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/ndt\/gfr015","article-title":"Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury","volume":"26","author":"Gatti","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"2022022509204513200_stem2557-bib-0054","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1186\/gb-2007-8-1-r3","article-title":"GENECODIS: A web-based tool for finding significant concurrent annotations in gene lists","volume":"8","author":"Carmona-Saez","year":"2007","journal-title":"Genome Biol"},{"key":"2022022509204513200_stem2557-bib-0055","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0301-472X(00)00482-3","article-title":"Mesenchymal stem cells","volume":"28","author":"Deans","year":"2000","journal-title":"Exp Hematol"},{"key":"2022022509204513200_stem2557-bib-0056","doi-asserted-by":"crossref","first-page":"W317","DOI":"10.1093\/nar\/gkp416","article-title":"GeneCodis: Interpreting gene lists through enrichment analysis and integration of diverse biological information","volume":"37","author":"Nogales-Cadenas","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2022022509204513200_stem2557-bib-0057","doi-asserted-by":"crossref","first-page":"W478","DOI":"10.1093\/nar\/gks402","article-title":"GeneCodis3: A non-redundant and modular enrichment analysis tool for functional genomics","volume":"40","author":"Tabas-Madrid","year":"2012","journal-title":"Nucleic Acids Res"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.2557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.2557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.2557","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/35\/4\/1093\/42604136\/stmcls_35_4_1093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/35\/4\/1093\/42604136\/stmcls_35_4_1093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:56:28Z","timestamp":1749948988000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/35\/4\/1093\/6423318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,5]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,5]]},"published-print":{"date-parts":[[2017,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.2557","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,4,1]]},"published":{"date-parts":[[2017,2,5]]}}}