{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:11:54Z","timestamp":1792782714170,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":1768,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000855","name":"University of Birmingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK Career Development Fellowship","doi-asserted-by":"publisher","award":["19899"],"award-info":[{"award-number":["19899"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK Senior Fellowship","doi-asserted-by":"publisher","award":["21236"],"award-info":[{"award-number":["21236"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/14\/28\/30774"],"award-info":[{"award-number":["PG\/14\/28\/30774"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["8500669699"],"award-info":[{"award-number":["8500669699"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20298"],"award-info":[{"award-number":["20298"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Birmingham Women's Health Care NHS Trust","id":[{"id":"https:\/\/ror.org\/02vjc4d72","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011327","name":"Sandwell and West Birmingham Hospitals NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic inflammation is associated with formation of ectopic fat deposits that might represent damage-induced aberrant mesenchymal stem cell (MSC) differentiation. Such deposits are associated with increased levels of inflammatory infiltrate and poor prognosis. Here we tested the hypothesis that differentiation from MSC to adipocytes in inflamed tissue might contribute to chronicity through loss of immunomodulatory function. We assessed the effects of adipogenic differentiation of MSC isolated from bone marrow or adipose tissue on their capacity to regulate neutrophil recruitment by endothelial cells and compared the differentiated cells to primary adipocytes from adipose tissue. Bone marrow derived MSC were immunosuppressive, inhibiting neutrophil recruitment to TNF\u03b1-treated endothelial cells (EC), but MSC-derived adipocytes were no longer able to suppress neutrophil adhesion. Changes in IL-6 and TGF\u03b21 signalling appeared critical for the loss of the immunosuppressive phenotype. In contrast, native stromal cells, adipocytes derived from them, and mature adipocytes from adipose tissue were all immunoprotective. Thus disruption of normal tissue stroma homeostasis, as occurs in chronic inflammatory diseases, might drive \u201cabnormal\u201d adipogenesis which adversely influences the behavior of MSC and contributes to pathogenic recruitment of leukocytes. Interestingly, stromal cells programmed in native fat tissue retain an immunoprotective phenotype.<\/jats:p>","DOI":"10.1002\/stem.2622","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T13:25:58Z","timestamp":1491398758000},"page":"1636-1646","source":"Crossref","is-referenced-by-count":51,"title":["Adipogenic Differentiation of Mesenchymal Stem Cells Alters Their Immunomodulatory Properties in a Tissue-Specific Manner"],"prefix":"10.1093","volume":"35","author":[{"given":"Hafsa","family":"Munir","sequence":"first","affiliation":[{"name":"a Institute for Cardiovascular Sciences, College of Medical and Dental Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis S. C.","family":"Ward","sequence":"additional","affiliation":[{"name":"b Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lozan","family":"Sheriff","sequence":"additional","affiliation":[{"name":"a Institute for Cardiovascular Sciences, College of Medical and Dental Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kemble","sequence":"additional","affiliation":[{"name":"b Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Nayar","sequence":"additional","affiliation":[{"name":"b Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barone","sequence":"additional","affiliation":[{"name":"b Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard B.","family":"Nash","sequence":"additional","affiliation":[{"name":"a Institute for Cardiovascular Sciences, College of Medical and Dental Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-8840","authenticated-orcid":false,"given":"Helen M.","family":"McGettrick","sequence":"additional","affiliation":[{"name":"b Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"2022022511345633500_stem2622-bib-0001","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1089\/scd.2015.0008","article-title":"Mesenchymal stem cells therapy for autoimmune disease: Risks and rewards","volume":"24","author":"Munir","year":"2015","journal-title":"Stem Cells Dev"},{"key":"2022022511345633500_stem2622-bib-0002","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nri3209","article-title":"Multipotent mesenchymal stromal cells and the innate immune system","volume":"12","author":"Le Blanc","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"2022022511345633500_stem2622-bib-0003","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1002\/stem.1511","article-title":"Crosstalk between mesenchymal stem cells and endothelial cells leads to downregulation of cytokine-induced leukocyte 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