{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:11:03Z","timestamp":1772035863813,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100005301","name":"American College of Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005405","name":"American Surgical Association Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Liver progenitor cells have the potential to repair and regenerate a diseased liver. The success of any translational efforts, however, hinges on thorough understanding of the fate of these cells after transplant, especially in terms of long-term safety and efficacy. Here, we report transplantation of a liver progenitor population isolated from human fetal livers into immune-permissive mice with follow-up up to 36 weeks after transplant. We found that human progenitor cells engraft and differentiate into functional human hepatocytes in the mouse, producing albumin, alpha-1-antitrypsin, and glycogen. They create tight junctions with mouse hepatocytes, with no evidence of cell fusion. Interestingly, they also differentiate into functional endothelial cell and bile duct cells. Transplantation of progenitor cells abrogated carbon tetrachloride-induced fibrosis in recipient mice, with downregulation of procollagen and anti-smooth muscle actin. Paradoxically, the degree of engraftment of human hepatocytes correlated negatively with the anti-fibrotic effect. Progenitor cell expansion was most prominent in cirrhotic animals, and correlated with transcript levels of pro-fibrotic genes. Animals that had resolution of fibrosis had quiescent native progenitor cells in their livers. No evidence of neoplasia was observed, even up to 9 months after transplantation. Human fetal liver progenitor cells successfully attenuate liver fibrosis in mice. They are activated in the setting of liver injury, but become quiescent when injury resolves, mimicking the behavior of de novo progenitor cells. Our data suggest that liver progenitor cells transplanted into injured livers maintain a functional role in the repair and regeneration of the liver.<\/jats:p>","DOI":"10.1002\/stem.2710","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:58:34Z","timestamp":1506614314000},"page":"103-113","source":"Crossref","is-referenced-by-count":26,"title":["Long-Term Fate of Human Fetal Liver Progenitor Cells Transplanted in Injured Mouse Livers"],"prefix":"10.1093","volume":"36","author":[{"given":"Antony","family":"Irudayaswamy","sequence":"first","affiliation":[{"name":"Department of Medicine, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Muthiah","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Singapore, Singapore"},{"name":"Division of Gastroenterology and Hepatology, National University Hospital. National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hau","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Halisah Bte","family":"Jumat","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamil","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narcissus","family":"Teoh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Australian National University, Canberra, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Medicine, Australian National University, Canberra, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly J.","family":"Riehle","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle, Washington, USA"},{"name":"Department of Surgery, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaymie Siqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin Lin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry Ky","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National University Singapore, Singapore"},{"name":"Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Choolani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng Cheang","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aileen","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Pathology, National University Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seng Gee","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine, National University Singapore, Singapore"},{"name":"Division of Gastroenterology and Hepatology, National University Hospital. 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