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Here, we demonstrate that Sox2 expression is enriched in the epithelial cells of the proximal prostate adjacent to the urethra. We use lineage tracing of Sox2-positive cells during prostatic development, homeostasis, and regeneration to show that the Sox2 lineage is capable of self-renewal and contributes to prostatic regeneration. Persisting luminal cells express Sox2 after castration, highlighting a potential role for Sox2 in cell survival and castration-resistance. In addition to revealing a novel progenitor population in the prostate, these data implicate Sox2 as a regulatory factor of adult prostate epithelial stem cells. Stem Cells \u00a02019;37:690\u2013700<\/jats:p>\n               <jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>","DOI":"10.1002\/stem.2987","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T18:14:55Z","timestamp":1549390495000},"page":"690-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sox2 Expression Marks Castration-Resistant Progenitor Cells in the Adult Murine Prostate"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3911-4390","authenticated-orcid":false,"given":"Erin","family":"McAuley","sequence":"first","affiliation":[{"name":"a The Committee on Molecular Pathogenesis and Molecular Medicine, The University of Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Moline","sequence":"additional","affiliation":[{"name":"b The Committee on Development, Regeneration, and Stem Cell Biology, The University of Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"VanOpstall","sequence":"additional","affiliation":[{"name":"c The Committee on Cancer Biology, The University of Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Lamperis","sequence":"additional","affiliation":[{"name":"d Department of Surgery, Section of Urology, The University of Chicago, Chicago, Illinois, USA"},{"name":"e Department of Pathology, The University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Brown","sequence":"additional","affiliation":[{"name":"d Department of Surgery, Section of Urology, The University of Chicago, Chicago, Illinois, USA"},{"name":"e Department of Pathology, The University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-5698","authenticated-orcid":false,"given":"Donald J.","family":"Vander Griend","sequence":"additional","affiliation":[{"name":"d Department of Surgery, Section of Urology, The University of Chicago, Chicago, Illinois, USA"},{"name":"e Department of Pathology, The University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"2022030205390723500_stem2987-bib-0001","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0002-9440(10)64814-6","article-title":"p63 is a prostate basal cell marker and is required for prostate development","volume":"157","author":"Signoretti","year":"2000","journal-title":"Am J Pathol"},{"key":"2022030205390723500_stem2987-bib-0002","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1101\/gad.819500","article-title":"Molecular genetics of prostate cancer","volume":"14","author":"Abate-Shen","year":"2000","journal-title":"Genes Dev"},{"key":"2022030205390723500_stem2987-bib-0003","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12015-008-9033-1","article-title":"Exploring the origins of the normal prostate and prostate cancer stem cell","volume":"4","author":"Kasper","year":"2008","journal-title":"Stem Cell Rev"},{"key":"2022030205390723500_stem2987-bib-0004","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jsbmb.2004.10.017","article-title":"Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development","volume":"92","author":"Cunha","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2022030205390723500_stem2987-bib-0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/pros.2990110304","article-title":"Response of glandular versus basal rat ventral prostatic epithelial cells to androgen withdrawal and replacement","volume":"11","author":"English","year":"1987","journal-title":"Prostate"},{"key":"2022030205390723500_stem2987-bib-0006","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/pros.2990100208","article-title":"Cell proliferation studies in rat prostate. 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