{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:30:14Z","timestamp":1790400614065,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HB037163"],"award-info":[{"award-number":["N01-HB037163"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21 HD060978"],"award-info":[{"award-number":["R21 HD060978"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32NS04712"],"award-info":[{"award-number":["T32NS04712"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01\u2010HB037163"],"award-info":[{"award-number":["N01\u2010HB037163"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21 HD060978"],"award-info":[{"award-number":["R21 HD060978"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32NS04712"],"award-info":[{"award-number":["T32NS04712"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cellular therapy is a promising investigational modality to enhance poststroke recovery. We conducted a single-arm, phase I clinical trial to determine the safety and feasibility of intravenous (IV) administration of autologous bone marrow mononuclear cells (MNCs) after acute ischemic stroke (AIS). Patients with moderate severity of AIS underwent bone marrow harvest followed by IV reinfusion of MNCs within 24\u201372\u2009hours of onset. A target dose of 10 million cells per kilogram was chosen based on preclinical data. Patients were followed up daily during hospitalization and at 1, 3, 6, 12, and 24\u2009months for incidence of adverse events using laboratory, clinical (12\u2009months), and radiological (24\u2009months) parameters. The trial was powered to detect severe adverse events (SAEs) with incidences of at least 10% and planned to enroll 30 patients. Primary outcomes were study-related SAEs and the proportion of patients successfully completing study intervention. A propensity score-based matched control group was used for the estimation of effect size (ES) for day-90 modified Rankin score (mRS). There were no study-related SAEs and, based on a futility analysis, enrolment was stopped after 25 patients. All patients successfully completed study intervention and most received the target dose. Secondary analysis estimated the ES to be a reduction of 1 point (95% confidence interval: 0.33\u20131.67) in median day-90 mRS for treated patients as compared with the matched control group. Bone marrow harvest and infusion of MNCs is safe and feasible in patients with AIS. The estimated ES is helpful in designing future randomized controlled trials. Stem Cells \u00a02019;37:1481\u20131491<\/jats:p><jats:sec><jats:title\/><\/jats:sec>","DOI":"10.1002\/stem.3080","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T11:45:39Z","timestamp":1568720739000},"page":"1481-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Intravenous Bone Marrow Mononuclear Cells for Acute Ischemic Stroke: Safety, Feasibility, and Effect Size from a Phase I Clinical Trial"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-2111","authenticated-orcid":false,"given":"Farhaan S.","family":"Vahidy","sequence":"first","affiliation":[{"name":"a Institute for Stroke and Cerebrovascular Disease and Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad E.","family":"Haque","sequence":"additional","affiliation":[{"name":"a Institute for Stroke and Cerebrovascular Disease and Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"Rahbar","sequence":"additional","affiliation":[{"name":"b Biostatistics\/Epidemiology\/Research Design (BERD) Core, Center for Clinical and Translational Sciences (CCTS), UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Zhu","sequence":"additional","affiliation":[{"name":"c Department of Biostatistics and Data Science, School of Public Health, UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Rowan","sequence":"additional","affiliation":[{"name":"d Department of Health Policy and Management, School of Public Health, UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imoigele P.","family":"Aisiku","sequence":"additional","affiliation":[{"name":"e Division of Emergency Critical Care, Department of Emergency Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Lee","sequence":"additional","affiliation":[{"name":"f Division of Pediatrics, Cell Therapy Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harinder S.","family":"Juneja","sequence":"additional","affiliation":[{"name":"g Hematology Division, Department of Medicine, UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Alderman","sequence":"additional","affiliation":[{"name":"a Institute for Stroke and Cerebrovascular Disease and Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Barreto","sequence":"additional","affiliation":[{"name":"a Institute for Stroke and Cerebrovascular Disease and Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose I.","family":"Suarez","sequence":"additional","affiliation":[{"name":"h Division of Neurosciences Critical Care, Department of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Bambhroliya","sequence":"additional","affiliation":[{"name":"a Institute for Stroke and Cerebrovascular Disease and Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khader M.","family":"Hasan","sequence":"additional","affiliation":[{"name":"i Department of Diagnostic and Interventional Imaging, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallikarjuna Rao","family":"Kassam","sequence":"additional","affiliation":[{"name":"j Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Aronowski","sequence":"additional","affiliation":[{"name":"a Institute for Stroke and Cerebrovascular Disease and Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Gee","sequence":"additional","affiliation":[{"name":"k Department of Medicine and Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Charles S.","family":"Cox","sequence":"additional","affiliation":[{"name":"l Department of Pediatric Surgery, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Grotta","sequence":"additional","affiliation":[{"name":"m Memorial Hermann Health System, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean I.","family":"Savitz","sequence":"additional","affiliation":[{"name":"a Institute for Stroke and Cerebrovascular Disease and Department of Neurology, McGovern Medical School at UTHealth, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"2022022514495435500_stem3080-bib-0001","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics\u20142018 update: A report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"2022022514495435500_stem3080-bib-0002","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1212\/01.wnl.0000436946.08647.b5","article-title":"Thrombolytic utilization for ischemic stroke in US hospitals with neurology residency program","volume":"81","author":"Moradiya","year":"2013","journal-title":"Neurology"},{"key":"2022022514495435500_stem3080-bib-0003","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1747-4949.2012.00840.x","article-title":"Stem cells in stroke treatment: The promise and the challenges","volume":"7","author":"Sinden","year":"2012","journal-title":"Int J Stroke"},{"key":"2022022514495435500_stem3080-bib-0004","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cne.22038","article-title":"Stem cells for ischemic brain injury: A critical review","volume":"515","author":"Burns","year":"2009","journal-title":"J Comp Neurol"},{"key":"2022022514495435500_stem3080-bib-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2003.09.084","article-title":"A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats","volume":"1007","author":"Iihoshi","year":"2004","journal-title":"Brain Res"},{"key":"2022022514495435500_stem3080-bib-0006","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2009.09.094","article-title":"Therapeutic window for treatment of cortical ischemia with bone marrow-derived cells in rats","volume":"1306","author":"Vasconcelos Dos Santos","year":"2010","journal-title":"Brain Res"},{"key":"2022022514495435500_stem3080-bib-0007","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1002\/jnr.22452","article-title":"Bone marrow mononuclear cells protect neurons and modulate microglia in cell culture models of ischemic stroke","volume":"88","author":"Sharma","year":"2010","journal-title":"J Neurosci Res"},{"key":"2022022514495435500_stem3080-bib-0008","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12975-011-0101-5","article-title":"Histopathological investigation of different MCAO modalities and impact of autologous bone marrow mononuclear cell administration in an ovine stroke model","volume":"2","author":"Boltze","year":"2011","journal-title":"Transl Stroke Res"},{"key":"2022022514495435500_stem3080-bib-0009","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jnr.22614","article-title":"Therapeutic time window and dose response of autologous bone marrow mononuclear cells for ischemic stroke","volume":"89","author":"Yang","year":"2011","journal-title":"J Neurosci Res"},{"key":"2022022514495435500_stem3080-bib-0010","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.0611112104","article-title":"Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia","volume":"104","author":"Baker","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022022514495435500_stem3080-bib-0011","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/stem.454","article-title":"Bone marrow mononuclear cells promote proliferation of endogenous neural stem cells through vascular niches after cerebral infarction","volume":"28","author":"Nakano-Doi","year":"2010","journal-title":"Stem Cells"},{"key":"2022022514495435500_stem3080-bib-0012","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1089\/scd.2012.0037","article-title":"Ischemic stroke may activate bone marrow mononuclear cells to enhance recovery after stroke","volume":"21","author":"Yang","year":"2012","journal-title":"Stem Cells Dev"},{"key":"2022022514495435500_stem3080-bib-0013","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1161\/STROKEAHA.116.012701","article-title":"Systematic review and meta-analysis of bone marrow\u2013derived mononuclear cells in animal models of ischemic stroke","volume":"47","author":"Vahidy","year":"2016","journal-title":"Stroke"},{"key":"2022022514495435500_stem3080-bib-0014","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/CIRCULATIONAHA.111.086074","article-title":"Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: A systematic review and meta-analysis","volume":"126","author":"Jeevanantham","year":"2012","journal-title":"Circulation"},{"key":"2022022514495435500_stem3080-bib-0015","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.jvs.2011.01.074","article-title":"Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia","volume":"53","author":"Murphy","year":"2011","journal-title":"J Vasc Surg"},{"key":"2022022514495435500_stem3080-bib-0016","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3171\/2012.8.JNS111446","article-title":"Dose-dependent facilitation of peripheral nerve regeneration by bone marrow-derived mononuclear cells: A randomized controlled study: Laboratory investigation","volume":"117","author":"Raheja","year":"2012","journal-title":"J Neurosurg"},{"key":"2022022514495435500_stem3080-bib-0017","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1227\/NEU.0b013e318207734c","article-title":"Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children","volume":"68","author":"Cox","year":"2011","journal-title":"Neurosurgery"},{"key":"2022022514495435500_stem3080-bib-0018","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/jcbfm.2009.198","article-title":"Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats","volume":"30","author":"Brenneman","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022022514495435500_stem3080-bib-0019","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ana.22458","article-title":"Intravenous autologous bone marrow mononuclear cells for ischemic stroke","volume":"70","author":"Savitz","year":"2011","journal-title":"Ann Neurol"},{"key":"2022022514495435500_stem3080-bib-0020","first-page":"194","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE)","author":"National Cancer Institute (U.S.)","year":"2009"},{"key":"2022022514495435500_stem3080-bib-0021","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fneur.2019.00141","article-title":"Serial cerebral metabolic changes in patients with ischemic stroke treated with autologous bone marrow derived mononuclear cells","volume":"10","author":"Haque","year":"2019","journal-title":"Front Neurol"},{"key":"2022022514495435500_stem3080-bib-0022","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-2377-13-61","article-title":"The University of Texas Houston Stroke Registry (UTHSR): Implementation of enhanced data quality assurance procedures improves data quality","volume":"13","author":"Rahbar","year":"2013","journal-title":"BMC Neurol"},{"key":"2022022514495435500_stem3080-bib-0023","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/aje\/kwf215","article-title":"Statistical analysis of correlated data using generalized estimating equations: An orientation","volume":"157","author":"Hanley","year":"2003","journal-title":"Am J Epidemiol"},{"key":"2022022514495435500_stem3080-bib-0024","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2307\/2532051","article-title":"A concordance correlation coefficient to evaluate reproducibility","volume":"45","author":"Lin","year":"1989","journal-title":"Biometrics"},{"key":"2022022514495435500_stem3080-bib-0025","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"2022022514495435500_stem3080-bib-0026","volume-title":"The Central Role of the Propensity Score in Observational Studies for Causal Effects","author":"Rosenbaum","year":"1982"},{"key":"2022022514495435500_stem3080-bib-0027","volume-title":"Epidemiology: Beyond the Basics","author":"Szklo","year":"2007"},{"key":"2022022514495435500_stem3080-bib-0028","volume-title":"Propensity Score Analysis: Statistical Methods and Applications","author":"Guo","year":"2010"},{"key":"2022022514495435500_stem3080-bib-0029","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/STROKEAHA.110.601914","article-title":"Stem cell therapy as an emerging paradigm for stroke (STEPS) II","volume":"42","author":"Savitz","year":"2011","journal-title":"Stroke"},{"key":"2022022514495435500_stem3080-bib-0030","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/stem.2538","article-title":"Treatment of severe adult traumatic brain injury using bone marrow mononuclear cells","volume":"35","author":"Cox","year":"2017","journal-title":"Stem Cells"},{"key":"2022022514495435500_stem3080-bib-0031","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3109\/02699052.2010.520298","article-title":"Analysis of homing potential of marrow-derived mononuclear cells in an experimentally-induced brain stroke mouse model","volume":"24","author":"Prabhakar","year":"2010","journal-title":"Brain Injury"},{"key":"2022022514495435500_stem3080-bib-0032","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3727\/096368914X684934","article-title":"Intra-arterial bone marrow mononuclear cell transplantation correlates with GM-CSF, PDGF-BB, and MMP-2 serum levels in stroke patients: Results from a clinical trial","volume":"23","author":"Moniche","year":"2014","journal-title":"Cell Transplant"},{"key":"2022022514495435500_stem3080-bib-0033","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/brain\/awr063","article-title":"Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke","volume":"134","author":"Honmou","year":"2011","journal-title":"Brain"},{"key":"2022022514495435500_stem3080-bib-0034","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/STROKEAHA.113.003379","article-title":"Stem cells as an emerging paradigm in stroke 3: Enhancing the development of clinical trials","volume":"45","author":"Savitz","year":"2014","journal-title":"Stroke"},{"key":"2022022514495435500_stem3080-bib-0035","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/STROKEAHA.114.007105","article-title":"One, two, three steps toward cell therapy for stroke","volume":"46","author":"Diamandis","year":"2015","journal-title":"Stroke"},{"key":"2022022514495435500_stem3080-bib-0036","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/sctm.19-0076","article-title":"Concise review: Stem cell therapy for stroke patients: Are we there yet?","volume":"8","author":"Borlongan","year":"2019","journal-title":"Stem Cells Translational Medicine"},{"key":"2022022514495435500_stem3080-bib-0037","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2217\/rme.13.2","article-title":"Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients","volume":"8","author":"Rosado-de-Castro","year":"2013","journal-title":"Regen Med"},{"key":"2022022514495435500_stem3080-bib-0038","first-page":"221","article-title":"Autologous intravenous bone marrow mononuclear cell therapy for patients with subacute ischaemic stroke: A pilot study","volume":"136","author":"Prasad","year":"2012","journal-title":"Indian J Med Res"},{"key":"2022022514495435500_stem3080-bib-0039","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1089\/scd.2015.0160","article-title":"Intravenous autologous bone marrow mononuclear cell transplantation for stroke: Phase1\/2a clinical trial in a homogeneous group of stroke patients","volume":"24","author":"Taguchi","year":"2015","journal-title":"Stem Cells Dev"},{"key":"2022022514495435500_stem3080-bib-0040","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.3727\/096368912X612512","article-title":"Intra-arterial infusion of autologous bone marrow mononuclear cells in patients with moderate to severe middle cerebral artery acute ischemic stroke","volume":"21","author":"Friedrich","year":"2012","journal-title":"Cell Transplant"},{"key":"2022022514495435500_stem3080-bib-0041","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1161\/STROKEAHA.112.659409","article-title":"Intra-arterial bone marrow mononuclear cells in ischemic stroke: A pilot clinical trial","volume":"43","author":"Moniche","year":"2012","journal-title":"Stroke"},{"key":"2022022514495435500_stem3080-bib-0042","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1161\/STROKEAHA.114.007028","article-title":"Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: A multicentric, randomized trial","volume":"45","author":"Prasad","year":"2014","journal-title":"Stroke"},{"key":"2022022514495435500_stem3080-bib-0043","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1089\/scd.2012.0404","article-title":"Challenges enrolling patients with acute ischemic stroke into cell therapy trials","volume":"22","author":"Vahidy","year":"2013","journal-title":"Stem Cells Dev"},{"key":"2022022514495435500_stem3080-bib-0044","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1161\/STROKEAHA.110.596379","article-title":"Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow","volume":"41","author":"Fujita","year":"2010","journal-title":"Stroke"},{"key":"2022022514495435500_stem3080-bib-0045","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1161\/STROKEAHA.108.533141","article-title":"Mechanisms underlying improved recovery of neurological function after stroke in the rodent after treatment with neurorestorative cell-based therapies","volume":"40","author":"Chopp","year":"2009","journal-title":"Stroke"},{"key":"2022022514495435500_stem3080-bib-0046","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/eurheartj\/ehs114","article-title":"Do observational studies using propensity score methods agree with randomized trials? A systematic comparison of studies on acute coronary syndromes","volume":"33","author":"Dahabreh","year":"2012","journal-title":"Eur Heart J"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.3080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.3080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.3080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/37\/11\/1481\/42612337\/stmcls_37_11_1481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/37\/11\/1481\/42612337\/stmcls_37_11_1481.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T16:09:08Z","timestamp":1721750948000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/37\/11\/1481\/6447864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,17]]},"references-count":46,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,9,17]]},"published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.3080","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11,1]]},"published":{"date-parts":[[2019,9,17]]},"assertion":[{"value":"2019-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}