{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:59:44Z","timestamp":1790996384191,"version":"4.1.0"},"reference-count":110,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Huntington's disease (HD) is a rare inherited neurodegenerative disease that manifests mostly in adulthood with progressive cognitive, behavioral, and motor dysfunction. Neuronal loss occurs predominantly in the striatum but also extends to other brain regions, notably the cortex. Most patients die around 20\u2009years after motor onset, although there is variability in the rate of progression and some phenotypic heterogeneity. The most advanced experimental therapies currently are huntingtin-lowering strategies, some of which are in stage 3 clinical trials. However, even if these approaches are successful, it is unlikely that they will be applicable to all patients or will completely halt continued loss of neural cells in all cases. On the other hand, cellular therapies have the potential to restore atrophied tissues and may therefore provide an important complementary therapeutic avenue. Pilot studies of fetal cell grafts in the 2000s reported the most dramatic clinical improvements yet achieved for this disease, but subsequent studies have so far failed to identify methodology to reliably reproduce these results. Moving forward, a major challenge will be to generate suitable donor cells from (nonfetal) cell sources, but in parallel there are a host of procedural and trial design issues that will be important for improving reliability of transplants and so urgently need attention. Here, we consider findings that have emerged from clinical transplant studies in HD to date, in particular new findings emerging from the recent multicenter intracerebral transplant HD study, and consider how these data may be used to inform future cell therapy trials.<\/jats:p>","DOI":"10.1002\/stem.3300","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T06:52:08Z","timestamp":1637909528000},"page":"144-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cell therapy in Huntington's disease: Taking stock of past studies to move the field forward"],"prefix":"10.1093","volume":"39","author":[{"given":"Anne-Catherine","family":"Bachoud-L\u00e9vi","sequence":"first","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, National Reference Center for Huntington's Disease, Neurology Department, Henri Mondor-Albert Chenevier Hospital, Cr\u00e9teil, France"},{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole Normale Sup\u00e9rieure, PSL University, Paris, France"},{"name":"Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe E01 NeuroPsychologie Interventionnelle, Cr\u00e9teil, France"},{"name":"NeurATRIS, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Massart","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, National Reference Center for Huntington's Disease, Neurology Department, Henri Mondor-Albert Chenevier Hospital, Cr\u00e9teil, France"},{"name":"D\u00e9partement d'Etudes Cognitives, \u00c9cole Normale Sup\u00e9rieure, PSL University, Paris, France"},{"name":"Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale, Equipe E01 NeuroPsychologie Interventionnelle, Cr\u00e9teil, France"},{"name":"NeurATRIS, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rosser","sequence":"additional","affiliation":[{"name":"Centre for Trials Research, Cardiff University, Cardiff, UK"},{"name":"Cardiff University Brain Repair Group, Life Sciences Building, School of Biosciences, Cardiff, UK"},{"name":"Neuroscience and Mental Health Research Institute and Division of Psychological Medicine and Clinical Neurosciences, Hadyn Ellis Building, Cardiff, UK"},{"name":"Brain Repair And Intracranial Neurotherapeutics (BRAIN) Unit, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"2022022510530960900_stem3300-bib-0001","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat Rev Dis 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