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Current stroke treatments (aspirin, tissue plasminogen activator) are significantly limited by timing and risks for hemorrhage which have driven researchers to explore other approaches. Stem cell-based therapy appears to be an effective option for ischemic stroke. Besides trans-differentiation into neural cells, stem cells also provide acute protection via paracrine signaling pathways through which releasing neuroprotective factors. We previously reported that intraperitoneal administration of human placenta mesenchymal stem cell (hPMSC) therapy upon reperfusion significantly protected the brain against middle cerebral artery occlusion (MCAO)-induced injury. In the present study, we specifically investigated the role of hPMSC-derived angiotensin converting enzyme-2 (ACE-2) in protection of MCAO-induced brain injury by measurement of brain tissue viability, cerebral blood flow, and neurological score. Here, we report for the first time that hPMSC expressing substantial amount of ACE-2, which mediates hPMSC protection in the MCAO model. Strikingly, we found that the protective effects of hPMSC in MCAO-induced brain injury could be attenuated by pretreatment of hPMSCs with MLN-4760, a specific inhibitor of ACE-2 activity, or by transfection of hPMSCs with ACE-2-shRNA-lentivirus. The hPMSC-derived ACE-2 specific protective mechanism was further demonstrated by administration of PD123319, an Angiotensin type-2 receptor antagonist, or A779, a MasR antagonist. Importantly, our study demonstrated that the protective effects of hPMSC in experimental stroke are ACE-2\/MasR dependent and this signaling pathway represents an innovative and highly promising approach for targeted stroke therapy.<\/jats:p>","DOI":"10.1002\/stem.3426","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T04:59:23Z","timestamp":1636606763000},"page":"1335-1348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Human Placenta Mesenchymal Stem Cell Protection in Ischemic Stroke is Angiotensin Converting Enzyme-2 and Masr Receptor-Dependent"],"prefix":"10.1093","volume":"39","author":[{"given":"Mansoureh","family":"Barzegar","sequence":"first","affiliation":[{"name":"Molecular and Cellular Physiology, Ochsner-LSU Health Sciences Center, Shreveport, Louisiana, 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