{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:07:26Z","timestamp":1791295646229,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"S1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6332,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cells"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1002\/stem.5530160721","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T15:35:52Z","timestamp":1245080152000},"page":"185-192","source":"Crossref","is-referenced-by-count":19,"special_numbering":"supplement S1","title":["A novel thrombopoietin signaling defect in polycythemia vera platelets"],"prefix":"10.1093","volume":"16","author":[{"given":"Alison R.","family":"Moliterno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Siebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Y.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. David","family":"Hankins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L.","family":"Spivak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"10.1002\/stem.5530160721-BIB1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJM197610212951702","article-title":"Polycythemia vera: stem‐cell and probable clonal origin of the disease","volume":"295","author":"Adamson","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1002\/stem.5530160721-BIB2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1182\/blood.V51.2.189.189","article-title":"Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis","volume":"51","author":"Jacobson","year":"1978","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1182\/blood.V56.1.70.70","article-title":"Philadelphia chromosome (Ph1)‐negative chronic myelogenous leukemia (CML): a clonal disease with origin in a multipotent stem cell","volume":"56","author":"Fialkow","year":"1980","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB4","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1182\/blood.V58.5.916.916","article-title":"Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell","volume":"58","author":"Fialkow","year":"1981","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB5","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1073\/pnas.89.12.5640","article-title":"Molecular cloning and characterization of MPL, the human homolog of the v‐mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily","volume":"89","author":"Vignon","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/stem.5530160721-BIB6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1182\/blood.V86.2.419.bloodjournal862419","article-title":"Thrombopoietin: the primary regulator of platelet production","volume":"86","author":"Kaushansky","year":"1995","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB7","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1182\/blood.V87.11.4544.bloodjournal87114544","article-title":"Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice","volume":"87","author":"Ku","year":"1996","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1182\/blood.V88.3.803.803","article-title":"Low levels of erythroid and myeloid progenitors in thrombopoietin‐and c‐mpl‐deficient mice","volume":"88","author":"Carver‐Moore","year":"1996","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB9","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1182\/blood.V86.11.4025.bloodjournal86114025","article-title":"Chronic exposure to retroviral vector encoded MGDF (mpl‐ligand) induces lineage‐specific growth and differentiation of megakaryocytes in mice","volume":"86","author":"Yan","year":"1995","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB10","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1182\/blood.V88.5.1656.1656","article-title":"Ectopic expression of murine TPO receptor (c‐mpl) in mice is pathogenic and induces erythroblastic proliferation","volume":"88","author":"Cocault","year":"1996","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0042-6822(86)90125-X","article-title":"MPLV: a retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice","volume":"149","author":"Wendling","year":"1986","journal-title":"Virology"},{"key":"10.1002\/stem.5530160721-BIB12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0092-8674(90)90410-G","article-title":"A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors","volume":"63","author":"Souyri","year":"1990","journal-title":"Cell"},{"key":"10.1002\/stem.5530160721-BIB13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1182\/blood.V85.2.391.391","article-title":"The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets","volume":"85","author":"Debili","year":"1995","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB14","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1182\/blood.V85.12.3444.bloodjournal85123444","article-title":"Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2","volume":"85","author":"Tortolani","year":"1995","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB15","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1074\/jbc.270.10.4979","article-title":"The c‐Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of JAK2, Shc, and c‐Mpl","volume":"270","author":"Drachman","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1002\/stem.5530160721-BIB16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0014-5793(95)01072-M","article-title":"Thrombopoietin, c‐Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists‐induced aggregation in platelets in vitro","volume":"374","author":"Ezumi","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1002\/stem.5530160721-BIB17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1182\/blood.V86.1.23.bloodjournal86123","article-title":"Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets","volume":"86","author":"Miyakawa","year":"1995","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1182\/blood.V87.2.439.bloodjournal872439","article-title":"Thrombopoietin induces tyrosine phosphorylation of STAT3 and STAT5 in human blood platelets","volume":"87","author":"Miyakawa","year":"1996","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB19","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1182\/blood.V85.10.2720.bloodjournal85102720","article-title":"The reciprocal relationship of thrombopoietin (c‐Mpl ligand) to changes in the platelet mass during busulfan‐induced thrombocytopenia in the rabbit","volume":"85","author":"Kuter","year":"1995","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB20","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1182\/blood.V87.10.4068.bloodjournal87104068","article-title":"Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to decreased platelet destruction","volume":"87","author":"Emmons","year":"1996","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1046\/j.1365-2141.1996.d01-1966.x","article-title":"Serum thrombopoietin levels in patients with aplastic anaemia","volume":"95","author":"Marsh","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1002\/stem.5530160721-BIB22","first-page":"1121","volume-title":"Hematology","author":"Hoffman","year":"1995"},{"key":"10.1002\/stem.5530160721-BIB23","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1172\/JCI114303","article-title":"Erythropoietin receptors in polycythemia vera","volume":"84","author":"Means","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1002\/stem.5530160721-BIB24","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1182\/blood.V87.4.1502.bloodjournal8741502","article-title":"Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies","volume":"87","author":"Le Couedic","year":"1996","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB25","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1365-2141.1994.tb05119.x","article-title":"Molecular analysis of the erythropoietin receptor system in patients with polycythaemia vera","volume":"88","author":"Hess","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1002\/stem.5530160721-BIB26","first-page":"2683","article-title":"Abnormalities of platelet function in patients with polycythemia vera","volume":"33","author":"Berger","year":"1973","journal-title":"Cancer Res"},{"key":"10.1002\/stem.5530160721-BIB27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/ajcp\/91.6.647","article-title":"Platelet function and structure in myeloproliferative disease, myelodysplastic syndrome and secondary thrombocytosis","volume":"91","author":"Raman","year":"1989","journal-title":"Am J Clin Pathol"},{"key":"10.1002\/stem.5530160721-BIB28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1056\/NEJM198202183060701","article-title":"Deficiency of platelet lipoxygenase activity in myeloproliferative disorders","volume":"306","author":"Schafer","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1002\/stem.5530160721-BIB29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1126\/science.7716517","article-title":"Cytokine signaling through nonreceptor protein tyrosine kinases","volume":"268","author":"Taniguchi","year":"1995","journal-title":"Science"},{"key":"10.1002\/stem.5530160721-BIB30","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1182\/blood.V88.11.4304.4304","article-title":"Crkl is constitutively tyrosine phospholylated in platelets from chronic myelogenous leukemia patients and inducibly phosphyorylated in normal platelets stimulated by thrombopoietin","volume":"88","author":"Oda","year":"1996","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB31","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1172\/JCI109497","article-title":"Characterization of the platelet prostaglandin D2 receptor. Loss of prostaglandin D2 receptors in platelets of patients with myeloproliferative disorders","volume":"64","author":"Cooper","year":"1979","journal-title":"J Clin Invest"},{"key":"10.1002\/stem.5530160721-BIB32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1056\/NEJM197809072991002","article-title":"Platelet function in essential thrombocythemia. Decreased epinephrine responsiveness associated with a deficiency of platelet α‐adrenergic receptors","volume":"299","author":"Kaywin","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1002\/stem.5530160721-BIB33","first-page":"132","article-title":"Therapeutic recommendations in polycythemia vera based on polycythemia vera study group protocols","volume":"23","author":"Berk","year":"1986","journal-title":"Semin Hematol"},{"key":"10.1002\/stem.5530160721-BIB34","first-page":"1455","article-title":"Early events in erythropoietin‐induced signaling","volume":"24","author":"Damen","year":"1996","journal-title":"Exp Hematol"},{"key":"10.1002\/stem.5530160721-BIB35","first-page":"981","article-title":"In polycythemia vera human interleukin 3 and granulocyte‐macrophage colony‐stimulating factor enhance erythroid colony growth in the absence of erythropoietin","volume":"17","author":"de Wolf","year":"1989","journal-title":"Exp Hematol"},{"key":"10.1002\/stem.5530160721-BIB36","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1182\/blood.V80.4.891.891","article-title":"Polycythemia vera. II. Hypersensitivity of bone marrow erythroid, granulocyte‐macrophage, and megakaryocyte progenitor cells to interleukin‐3 and granulocyte‐macrophage colony‐stimulating factor","volume":"80","author":"Dai","year":"1992","journal-title":"Blood"},{"key":"10.1002\/stem.5530160721-BIB37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2141.1994.tb03246.x","article-title":"Polycythemia vera. III. Burst‐forming units‐erythroid (BFU‐E) response to stem cell factor and c‐kit receptor expression","volume":"86","author":"Dai","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1002\/stem.5530160721-BIB38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1182\/blood.V83.1.99.99","article-title":"Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin‐like growth factor‐1 in vitro: studies in an improved serum‐free medium","volume":"83","author":"Correa","year":"1994","journal-title":"Blood"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.5530160721","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/stem.5530160721\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T03:09:32Z","timestamp":1642561772000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/16\/S1\/185-192\/6391318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":38,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[1998,5]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.5530160721","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}