{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:34:14Z","timestamp":1788042854944,"version":"build-2784847793"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Institutes of Health National Institute of Neurological Disorders and Stroke","award":["NS058784"],"award-info":[{"award-number":["NS058784"]}]},{"name":"National Institutes of Health National Institute of Neurological Disorders and Stroke","award":["NS27292"],"award-info":[{"award-number":["NS27292"]}]},{"name":"National Institutes of Health National Institute of Neurological Disorders and Stroke","award":["NS37520"],"award-info":[{"award-number":["NS37520"]}]},{"name":"William Randolph Hearst Foundation, Bernard and Ronni Lacroute, Russell and Elizabeth Siegelman, and the Edward E. Hills Fund"},{"name":"Ministry of Education and Science of Spain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cell transplantation offers a novel therapeutic strategy for stroke; however, how transplanted cells function in vivo is poorly understood. We show for the first time that after subacute transplantation into the ischemic brain of human central nervous system stem cells grown as neurospheres (hCNS-SCns), the stem cell-secreted factor, human vascular endothelial growth factor (hVEGF), is necessary for cell-induced functional recovery. We correlate this functional recovery to hVEGF-induced effects on the host brain including multiple facets of vascular repair and its unexpected suppression of the inflammatory response. We found that transplanted hCNS-SCns affected multiple parameters in the brain with different kinetics: early improvement in blood-brain barrier integrity and suppression of inflammation was followed by a delayed spatiotemporal regulated increase in neovascularization. These events coincided with a bimodal pattern of functional recovery, with, an early recovery independent of neovascularization, and a delayed hVEGF-dependent recovery coincident with neovascularization. Therefore, cell transplantation therapy offers an exciting multimodal strategy for brain repair in stroke and potentially other disorders with a vascular or inflammatory component.<\/jats:p>","DOI":"10.1002\/stem.584","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T17:28:54Z","timestamp":1295026134000},"page":"274-285","source":"Crossref","is-referenced-by-count":214,"title":["Transplanted Stem Cell-Secreted Vascular Endothelial Growth Factor Effects Poststroke Recovery, Inflammation, and Vascular Repair"],"prefix":"10.1093","volume":"29","author":[{"given":"Nobutaka","family":"Horie","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta P.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyasu","family":"Niizuma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadar","family":"Keren-Gill","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Encarnacion","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Shamloo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Huhn","sequence":"additional","affiliation":[{"name":"StemCells Inc., Palo Alto, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya M.","family":"Bliss","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stanford Stroke Center, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,2,24]]},"reference":[{"key":"2022011210352903600_bib1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/exnr.1997.6730","article-title":"Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats","volume":"149","author":"Borlongan","year":"1998","journal-title":"Exp Neurol"},{"key":"2022011210352903600_bib2","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"2022011210352903600_bib3","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1460-9568.2008.06599.x","article-title":"Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: Cell survival and functional recovery","volume":"29","author":"Hicks","year":"2009","journal-title":"Eur J Neurosci"},{"key":"2022011210352903600_bib4","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.2741\/2842","article-title":"Development of a human neural stem cell line for use in recovery from disability after stroke","volume":"13","author":"Stroemer","year":"2008","journal-title":"Front Biosci"},{"key":"2022011210352903600_bib5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.STR.0000247888.25985.62","article-title":"Cell transplantation therapy for stroke","volume":"38","author":"Bliss","year":"2007","journal-title":"Stroke"},{"key":"2022011210352903600_bib6","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.3171\/FOC\/2008\/24\/3-4\/E14","article-title":"Intravascular cell replacement therapy for stroke","volume":"24","author":"Guzman","year":"2008","journal-title":"Neurosurg Focus"},{"key":"2022011210352903600_bib7","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1371\/journal.pone.0000156","article-title":"Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model","volume":"2","author":"Lee","year":"2007","journal-title":"Plos One"},{"key":"2022011210352903600_bib8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1227\/01.NEU.0000290907.30814.42","article-title":"Vascular endothelial growth factor gene-transferred bone marrow stromal cells engineered with a herpes simplex virus type 1 vector can improve neurological deficits and reduce infarction volume in rat brain ischemia","volume":"61","author":"Miki","year":"2007","journal-title":"Neurosurgery"},{"key":"2022011210352903600_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/0140-6736(93)91734-4","article-title":"Prognostic value of blood vessel density in ischaemic stroke","volume":"342","author":"Krupinski","year":"1993","journal-title":"Lancet"},{"key":"2022011210352903600_bib10","first-page":"817","article-title":"Angiogenesis and functional recovery demonstrated after minor stroke","volume":"358","author":"Senior","year":"2001","journal-title":"Lancet"},{"key":"2022011210352903600_bib11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.jcbfm.9600527","article-title":"Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia","volume":"28","author":"Onda","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022011210352903600_bib12","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1172\/JCI200420622","article-title":"Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model","volume":"114","author":"Taguchi","year":"2004","journal-title":"J Clin Invest"},{"key":"2022011210352903600_bib13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.RES.0000063425.51108.8D","article-title":"Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats","volume":"92","author":"Chen","year":"2003","journal-title":"Circ Res"},{"key":"2022011210352903600_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/156720206776875902","article-title":"Cerebral ischemia and angiogenesis","volume":"3","author":"Hayashi","year":"2006","journal-title":"Curr Neurovasc Res"},{"key":"2022011210352903600_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/CS20060049","article-title":"Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential","volume":"111","author":"Slevin","year":"2006","journal-title":"Clin Sci (Lond)"},{"key":"2022011210352903600_bib16","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1007\/s11064-007-9342-9","article-title":"Cell-cell signaling in the neurovascular unit","volume":"32","author":"Lok","year":"2007","journal-title":"Neurochem Res"},{"key":"2022011210352903600_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1007074420772","article-title":"Inflammatory mediators and modulation of blood-brain barrier permeability","volume":"20","author":"Abbott","year":"2000","journal-title":"Cell Mol Neurobiol"},{"key":"2022011210352903600_bib18","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1523\/JNEUROSCI.2674-08.2008","article-title":"Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice","volume":"28","author":"McColl","year":"2008","journal-title":"J Neurosci"},{"key":"2022011210352903600_bib19","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.neuroscience.2008.08.028","article-title":"Inflammation and the neurovascular unit in the setting of focal cerebral ischemia","volume":"158","author":"del Zoppo","year":"2009","journal-title":"Neuroscience"},{"key":"2022011210352903600_bib20","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/brain\/awm306","article-title":"Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke","volume":"131","author":"Lee","year":"2008","journal-title":"Brain"},{"key":"2022011210352903600_bib21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/scd.2005.14.595","article-title":"Anti-inflammatory effects of human cord blood cells in a rat model of stroke","volume":"14","author":"Vendrame","year":"2005","journal-title":"Stem Cells Dev"},{"key":"2022011210352903600_bib22","doi-asserted-by":"crossref","first-page":"14638","DOI":"10.1073\/pnas.0803670105","article-title":"Stem\/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory\/immune responses","volume":"105","author":"Ohtaki","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011210352903600_bib23","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/brain\/awp174","article-title":"Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms","volume":"132","author":"Bacigaluppi","year":"2009","journal-title":"Brain"},{"key":"2022011210352903600_bib24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nature03889","article-title":"Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism","volume":"436","author":"Pluchino","year":"2005","journal-title":"Nature"},{"key":"2022011210352903600_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0090-1229(80)90033-1","article-title":"The athymic nude rat. II. Immunological characteristics","volume":"15","author":"Vos","year":"1980","journal-title":"Clin Immunol Immunopathol"},{"key":"2022011210352903600_bib26","doi-asserted-by":"crossref","first-page":"11839","DOI":"10.1073\/pnas.0404474101","article-title":"Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex","volume":"101","author":"Kelly","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011210352903600_bib27","doi-asserted-by":"crossref","first-page":"14720","DOI":"10.1073\/pnas.97.26.14720","article-title":"Direct isolation of human central nervous system stem cells","volume":"97","author":"Uchida","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011210352903600_bib28","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.neo.7900102","article-title":"Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption","volume":"2","author":"Rubenstein","year":"2000","journal-title":"Neoplasia"},{"key":"2022011210352903600_bib29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.expneurol.2004.09.005","article-title":"Testing forelimb placing \u201cacross the midline\u201d reveals distinct, lesion-dependent patterns of recovery in rats","volume":"191","author":"Woodlee","year":"2005","journal-title":"Exp Neurol"},{"key":"2022011210352903600_bib30","doi-asserted-by":"crossref","first-page":"10211","DOI":"10.1073\/pnas.0608519104","article-title":"Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI","volume":"104","author":"Guzman","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011210352903600_bib31","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0408258102","article-title":"Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway","volume":"101","author":"Imitola","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022011210352903600_bib32","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1523\/JNEUROSCI.4323-06.2006","article-title":"A neurovascular niche for neurogenesis after stroke","volume":"26","author":"Ohab","year":"2006","journal-title":"J Neurosci"},{"key":"2022011210352903600_bib33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd1381","article-title":"Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer","volume":"3","author":"Ferrara","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"2022011210352903600_bib34","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1161\/01.STR.0000173408.94728.79","article-title":"Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia","volume":"36","author":"Veltkamp","year":"2005","journal-title":"Stroke"},{"key":"2022011210352903600_bib35","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/sj.jcbfm.9600378","article-title":"Stroke-evoked angiogenesis results in a transient population of microvessels","volume":"27","author":"Yu","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022011210352903600_bib36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood-brain barrier in health and chronic neurodegenerative disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"key":"2022011210352903600_bib37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2008.08.005","article-title":"Blood-brain barrier tight junction permeability and ischemic stroke","volume":"32","author":"Sandoval","year":"2008","journal-title":"Neurobiol Dis"},{"key":"2022011210352903600_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"2022011210352903600_bib39","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/sj.jcbfm.9600585","article-title":"The rapid decrease in astrocyte-associated dystroglycan expression by focal cerebral ischemia is protease-dependent","volume":"28","author":"Milner","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022011210352903600_bib40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/glia.10216","article-title":"Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice","volume":"42","author":"Nico","year":"2003","journal-title":"Glia"},{"key":"2022011210352903600_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0968-0004(00)01731-X","article-title":"The complexities of dystroglycan","volume":"26","author":"Winder","year":"2001","journal-title":"Trends Biochem Sci"},{"key":"2022011210352903600_bib42","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1523\/JNEUROSCI.5165-05.2006","article-title":"Intracerebral peripheral blood stem cell (CD34+) implantation induces neuroplasticity by enhancing beta1 integrin-mediated angiogenesis in chronic stroke rats","volume":"26","author":"Shyu","year":"2006","journal-title":"J Neurosci"},{"key":"2022011210352903600_bib43","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00004647-200204000-00002","article-title":"Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia","volume":"22","author":"Zhang","year":"2002","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022011210352903600_bib44","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0306-4522(01)00092-6","article-title":"Dystroglycan distribution in adult mouse brain: A light and electron microscopy study","volume":"104","author":"Zaccaria","year":"2001","journal-title":"Neuroscience"},{"key":"2022011210352903600_bib45","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1161\/01.ATV.0000232525.65682.a2","article-title":"Integrin-matrix interactions in the cerebral microvasculature","volume":"26","author":"del Zoppo","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022011210352903600_bib46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1152\/physrev.00031.2008","article-title":"Role and therapeutic potential of VEGF in the nervous system","volume":"89","author":"Ruiz de Almodovar","year":"2009","journal-title":"Physiol Rev"},{"key":"2022011210352903600_bib47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainres.2008.07.116","article-title":"Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult rats","volume":"1236","author":"Omori","year":"2008","journal-title":"Brain Res"},{"key":"2022011210352903600_bib48","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2004.02.072","article-title":"Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats","volume":"1010","author":"Borlongan","year":"2004","journal-title":"Brain Res"},{"key":"2022011210352903600_bib49","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/sj.jcbfm.9600475","article-title":"Angiopoietin1\/Tie2 and VEGF\/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke","volume":"27","author":"Zacharek","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022011210352903600_bib50","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.vph.2006.01.008","article-title":"Contraindications of VEGF-based therapeutic angiogenesis: Effects on macrophage density and histology of normal and ischemic brains","volume":"44","author":"Manoonkitiwongsa","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"2022011210352903600_bib51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0925-5710(95)00412-2","article-title":"Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor","volume":"62","author":"Broxmeyer","year":"1995","journal-title":"Int J Hematol"},{"key":"2022011210352903600_bib52","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1096-1096","article-title":"Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells","volume":"2","author":"Gabrilovich","year":"1996","journal-title":"Nat Med"},{"key":"2022011210352903600_bib53","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1182\/blood-2002-07-1956","article-title":"VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression","volume":"101","author":"Ohm","year":"2003","journal-title":"Blood"},{"key":"2022011210352903600_bib54","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc2403","article-title":"VEGF-targeted therapy: Mechanisms of anti-tumour activity","volume":"8","author":"Ellis","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"2022011210352903600_bib55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1471-4159.2007.04773.x","article-title":"Vitamin transport, homeostasis in mammalian brain: Focus on Vitamins B, E","volume":"103","author":"Spector","year":"2007","journal-title":"J Neurochem"},{"key":"2022011210352903600_bib56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.stem.2008.09.001","article-title":"The systematic production of cells for cell therapies","volume":"3","author":"Kirouac","year":"2008","journal-title":"Cell Stem Cell"}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fstem.584","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/stem.584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/stem.584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/29\/2\/274\/41967714\/stmcls_29_2_274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/29\/2\/274\/41967714\/stmcls_29_2_274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T03:10:06Z","timestamp":1642561806000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/29\/2\/274-285\/6403516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,1]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,24]]},"published-print":{"date-parts":[[2011,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/stem.584","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,2,1]]},"published":{"date-parts":[[2011,2,1]]}}}