{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T22:57:56Z","timestamp":1772665076696,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,10,19]],"date-time":"2001-10-19T00:00:00Z","timestamp":1003449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2001,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of ketamine anesthesia on the binding of [<jats:sup>11<\/jats:sup>C]\u2010labeled cocaine analogs, [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CFT (2\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010fluorophenyl)tropane) and [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CIT\u2010FE (<jats:italic>N<\/jats:italic>\u2010(2\u2010fluoroethyl)\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)tropane), to the striatal dopamine transporter (DAT) were evaluated in the monkey brain using positron emission tomography (PET). We sequentially measured the kinetics of these labeled compounds in the brains of five young\u2010adult male rhesus monkeys (<jats:italic>Macaca mulatta<\/jats:italic>) in the conscious state, followed by those under ketamine anesthesia with continuous infusion (3 and 10 mg\/kg\/h). After intravenous injection, [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CFT and [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CIT\u2010FE were predominantly accumulated in the striatum in both conscious and ketamine\u2010anesthetized states. In the conscious state, the striatal uptake of [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CFT and [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CIT\u2010FE continuously increased with time up to 91 min after injection. Continuous infusion of ketamine\u2010induced higher levels of uptake of [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CFT and [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CIT\u2010FE into the brain in a dose\u2010dependent manner as compared with conscious state, and kinetic analysis with metabolite\u2010corrected arterial input function indicated that the binding potentials (BP = k<jats:sub>3<\/jats:sub>\/k<jats:sub>4<\/jats:sub>) of both compounds were elevated by ketamine. Not only [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CIT\u2010FE but also [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CFT reached the equilibrium state of specific binding in the striatum within 40\u201350 min after injection. The present results demonstrated that ketamine significantly alters the DAT availability as measured with [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CFT and [<jats:sup>11<\/jats:sup>C]\u03b2\u2010CIT\u2010FE in the brain. Synapse 42:273\u2013280, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.10012","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:15:54Z","timestamp":1030310154000},"page":"273-280","source":"Crossref","is-referenced-by-count":59,"title":["Ketamine alters the availability of striatal dopamine transporter as measured by [<sup>11<\/sup>C]\u03b2\u2010CFT and [<sup>11<\/sup>C]\u03b2\u2010CIT\u2010FE in the monkey 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