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This study describes, for the first time, the phenotype of congenic D<jats:sub>3<\/jats:sub>\u2010null mice. Initially, 129\/Sv \u00d7 C57BL\/6 D<jats:sub>3<\/jats:sub>\u2010null mice were backcrossed 14 times onto C57BL\/6; they were then assessed using an ethologically based approach which resolves all topographies of behaviour within the mouse repertoire. The ethogram of D<jats:sub>3<\/jats:sub>\u2010null mice, on comparison with wildtypes, was characterised by no alteration in any topography of behaviour over an initial period of exploration; subsequent assessment over several hours revealed only increased rearing among females due to delayed habituation. Low doses of the selective D<jats:sub>2<\/jats:sub>\u2010like agonist RU 24213 (0.016\u20130.25 mg\/kg) inhibited topographies of exploratory behaviour; this effect was diminished in D<jats:sub>3<\/jats:sub>\u2010null mice only when investigated following prolonged habituation, and then only for certain topographies of behaviour, primarily sniffing and rearing. High doses of RU 24213 (0.1\u201312.5 mg\/kg) induced stereotyped sniffing and \u201cponderous\u201d locomotion, while the selective D<jats:sub>1<\/jats:sub>\u2010like agonist SK&amp;F 83959 (0.016\u20132.0 mg\/kg) promoted characteristic grooming syntax; these effects did not differ materially between the genotypes. When examined topographically on an essentially congenic C57BL\/6 background (&lt;0.005% 129\/Sv), the resultant phenotype indicated essential conservation of the mouse ethogram, high\u2010dose D<jats:sub>2<\/jats:sub>\u2010like stimulatory effects, and D<jats:sub>1<\/jats:sub>\u2010like stimulatory effects in the absence of D<jats:sub>3<\/jats:sub> receptors. A role for D<jats:sub>3<\/jats:sub> receptors in inhibitory processes appeared topographically circumscribed and only when baseline levels of behaviour were low. Synapse 46:19\u201331, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.10108","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:53:08Z","timestamp":1033905188000},"page":"19-31","source":"Crossref","is-referenced-by-count":33,"title":["Phenotypic, ethologically based resolution of spontaneous and D<sub>2<\/sub>\u2010like vs D<sub>1<\/sub>\u2010like agonist\u2010induced behavioural topography in mice with congenic D<sub>3<\/sub> dopamine receptor \u201cknockout\u201d"],"prefix":"10.1002","volume":"46","author":[{"given":"Fergal N.","family":"McNamara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah J.","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orna","family":"Tighe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Kinsella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Drago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Croke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Waddington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.1945"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00970-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00825-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90690-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(20000901)37:3<194::AID-SYN3>3.0.CO;2-A"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00213-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00064-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050567"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00116-6"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00297-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00150-1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00246-9"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5420.1670"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050327"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244332"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb16420.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(80)90190-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)20020-7"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00035-X"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.29406"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00705-2"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00347-2"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-09-03470.1998"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-02231.1998"},{"key":"e_1_2_1_26_1","first-page":"231","article-title":"The D3 dopamine receptor: neurobiology and potential clinical relevance","volume":"49","author":"Levant B","year":"1997","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01356-8"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.6.2196"},{"key":"e_1_2_1_29_1","first-page":"323","article-title":"Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice","volume":"79","author":"Mercuri NB","year":"1997","journal-title":"Neuroscience"},{"key":"e_1_2_1_30_1","first-page":"1048","article-title":"S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)\u2010receptors. 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