{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:28:47Z","timestamp":1761236927598},"reference-count":78,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,9,27]],"date-time":"2002-09-27T00:00:00Z","timestamp":1033084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2002,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the effect of (\u00b1)\u2010gamma\u2010vinyl GABA (GVG, Vigabatrin), an irreversible inhibitor of the enzyme GABA transaminase, on the acquisition and expression of cocaine\u2010induced sensitization in albino male Sprague\u2010Dawley rats. Animals received a single injection of 1 ml\/kg i.p. of 0.9% saline or 15 mg\/kg i.p. of (\u2212)\u2010cocaine and locomotor activity was assessed using automated locomotor cages and stereotyped behaviors were scored using a 4\u2010point rating scale (Day 1). Subsequently, animals were given 15 mg\/kg i.p. of cocaine every 48 h in their home cage for 1 week (Days 3, 5, and 7) and then given no treatment for 1 week. A challenge injection of 15 mg\/kg i.p. of cocaine, but not vehicle, produced a significant increase in locomotor activity and stereotyped behaviors on Day 15 compared to animals that received cocaine on Day 1. Administration of 75 mg\/kg i.p. of GVG 2.5 h before the cocaine injections did not significantly alter the acquisition of cocaine\u2010induced locomotor sensitization. However, 150 mg\/kg i.p. of GVG significantly attenuated the acquisition of cocaine\u2010induced locomotor sensitization. Administration of 150 mg\/kg i.p. of GVG 2.5 h before the cocaine challenge injection on Day 15 significantly attenuated the expression of cocaine\u2010induced locomotor sensitization. Acquisition and expression of cocaine\u2010induced sensitization of stereotypy was also significantly attenuated by 150 mg\/kg i.p. of GVG. Since sensitization may be one of the factors involved in relapse to drug use, the present results, in combination with previous findings that GVG blocks the rewarding and incentive motivating effects of cocaine, suggest that GVG might prove useful in the treatment of cocaine addiction. Synapse 46:240\u2013250, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.10138","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T09:11:16Z","timestamp":1034154676000},"page":"240-250","source":"Crossref","is-referenced-by-count":32,"title":["Gamma\u2010vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine\u2010induced sensitization in male rats"],"prefix":"10.1002","volume":"46","author":[{"given":"Eliot L.","family":"Gardner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wynne K.","family":"Schiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan A.","family":"Horan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Highfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Dewey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Brodie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Charles R.","family":"Ashby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,27]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"51","article-title":"Implications of the GABAB receptor in gamma vinyl\u2010GABA's inhibition of cocaine\u2010induced increases in nucleus accumbens dopamine","volume":"32","author":"Ashby CR","year":"1999","journal-title":"Synapse"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(96)00164-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00019-8"},{"key":"e_1_2_1_5_1","first-page":"15","article-title":"The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain \u03b3\u2010aminobutyric acid type B receptors negatively coupled to voltage\u2010dependent calcium channels","volume":"298","author":"Bertrand S","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90824-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0722397.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb25960.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890110204"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00368.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00293-7"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199704)25:4<393::AID-SYN11>3.0.CO;2-W"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199810)30:2<119::AID-SYN1>3.0.CO;2-F"},{"key":"e_1_2_1_14_1","first-page":"199","article-title":"The effect of repeated doses of cocaine on the rat","volume":"46","author":"Downs AW","year":"1932","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_15_1","first-page":"1148","article-title":"Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine\u2010induced seizures","volume":"290","author":"Gasior M","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90355-C"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00122-0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)80005-4"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00815-2"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1523\/JNEUROSCI.15-09-06287.1995","article-title":"The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons","volume":"15","author":"Henry DJ","year":"1995","journal-title":"J Neurosci"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2347662"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000394"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10721.x"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199911)34:2<103::AID-SYN3>3.0.CO;2-Z"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(93)90008-N"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(94)01063-Q"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70041497.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(91)90007-U"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199308000-00005"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988119801200107"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245070"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000026529"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050224"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00926-7"},{"key":"e_1_2_1_34_1","volume-title":"Experimental design: procedures for the behavioral sciences","author":"Kirk RE","year":"1982"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.3.482"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01203-6"},{"key":"e_1_2_1_37_1","first-page":"797","article-title":"The irreversible gamma\u2010aminobutyric acid (GABA) transaminase inhibitor gamma\u2010vinyl\u2010GABA blocks cocaine self\u2010administration in rats","volume":"290","author":"Kushner SA","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0028-3908(01)00140-X","article-title":"GABA peritin is not a GABAB receptor agonist","volume":"41","author":"Lanneau C","journal-title":"Neuropharmacology"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91313-P"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1977.tb11410.x"},{"key":"e_1_2_1_41_1","first-page":"27","article-title":"Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy","volume":"162","author":"Mattson RH","year":"1995","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(92)90057-Z"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(93)90059-G"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199810)30:2<211::AID-SYN11>3.0.CO;2-4"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1201\/b15236"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199801)28:1<60::AID-SYN7>3.0.CO;2-A"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.1.144"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(81)80001-9"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244651"},{"key":"e_1_2_1_50_1","first-page":"1002","article-title":"Repeated cocaine injections decrease the function of striatal gamma\u2010aminobutyric acid (A) receptors","volume":"276","author":"Peris J","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_51_1","first-page":"38","article-title":"Persistence of neurochemical changes in dopamine systems after repeated cocaine administration","volume":"253","author":"Peris J","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00102-8"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740605"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00227.x"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00021-0"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00366-7"},{"key":"e_1_2_1_57_1","first-page":"169","volume-title":"Stimulants: neurochemical, behavioral and clinical perspectives","author":"Post RM","year":"1983"},{"key":"e_1_2_1_58_1","first-page":"115","volume-title":"Caldwell","author":"Post RM","year":"1992"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0731539.x"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2001.9611038.x"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-8833-2_4"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90073-6"},{"key":"e_1_2_1_63_1","first-page":"450","article-title":"Behavioral and biochemical evidence of opioidergic involvement in cocaine sensitization","volume":"274","author":"Sala M","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_64_1","first-page":"1","article-title":"Dopamine\u2010GABA interactions: evidence that GABA transmits, modulates and mediates dopaminergic function in the basal ganglia and the limbic system","volume":"107","author":"Scheel\u2010Kruger J","year":"1986","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_1_65_1","first-page":"56","article-title":"Stimulant preexposure sensitizes rats and humans to the rewarding effects of cocaine","volume":"169","author":"Schenk S","year":"1998","journal-title":"NIDA Res Monogr Ser"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90858-3"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00450-9"},{"key":"e_1_2_1_68_1","first-page":"545","article-title":"Kappa\u2010opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine","volume":"276","author":"Shippenberg TS","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(94)00176-G"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(98)00083-7"},{"key":"e_1_2_1_71_1","first-page":"S39","article-title":"Mechanisms of action of gabapentin","volume":"153","author":"Taylor CP","year":"1997","journal-title":"Rev Neurol"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00834.x"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000493"},{"key":"e_1_2_1_74_1","first-page":"261","volume-title":"Boca Raton","author":"White FJ","year":"1992"},{"key":"e_1_2_1_75_1","volume-title":"Statistical principles in experimental design","author":"Winer BJ","year":"1971"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00090-7"},{"key":"e_1_2_1_77_1","first-page":"229","volume-title":"Cocaine: pharmacology, physiology and clinical strategies","author":"Zahniser NR","year":"1992"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90655-F"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.10138","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.10138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T13:44:07Z","timestamp":1700315047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.10138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,27]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,12,15]]}},"alternative-id":["10.1002\/syn.10138"],"URL":"https:\/\/doi.org\/10.1002\/syn.10138","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,27]]}}}