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This study examined, by in situ hybridization histochemistry, the effects of continuous or intermittent L\u2010DOPA administration on gene expression in the globus pallidus and subthalamic nucleus of adult rats with a unilateral 6\u2010hydroxydopamine (6\u2010OHDA) lesion of the nigrostriatal pathway. Results were compared to 6\u2010OHDA\u2010treated rats receiving vehicle. Our results provide original evidence that continuous L\u2010DOPA normalizes the 6\u2010OHDA\u2010lesion\u2010induced increase in mRNA levels encoding for the 67 kDa isoform of glutamate decarboxylase in neurons of the globus pallidus and cytochrome oxidase subunit I mRNA levels in the subthalamic nucleus. The extent of normalization did not differ between the continuous and intermittent groups. In addition, intermittent L\u2010DOPA induced an increase in the mRNA levels encoding for the 65 kDa isoform of glutamate decarboxylase in globus pallidus neurons ipsilateral to the lesion and a bilateral increase in c\u2010fos mRNA expression in the subthalamic nucleus. These results suggest that continuous L\u2010DOPA tends to normalize the 6\u2010OHDA\u2010lesion\u2010induced alterations in cell signaling in the pallido\u2010subthalamic loop. On the other hand, we propose that chronic intermittent L\u2010DOPA exerts a dual effect by normalizing cell signaling in a subpopulation of neurons in the globus pallidus and subthalamic nucleus while inducing abnormal signaling in another subpopulation. Synapse 49:246\u2013260, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.10234","type":"journal-article","created":{"date-parts":[[2003,6,23]],"date-time":"2003-06-23T10:16:29Z","timestamp":1056363389000},"page":"246-260","source":"Crossref","is-referenced-by-count":22,"title":["Dual effects of intermittent or continuous L\u2010DOPA administration on gene expression in the globus pallidus and subthalamic nucleus of adult rats with a unilateral 6\u2010OHDA lesion"],"prefix":"10.1002","volume":"49","author":[{"given":"Kirsten 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