{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:53:44Z","timestamp":1759683224493},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,5,9]],"date-time":"2001-05-09T00:00:00Z","timestamp":989366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>GABA<jats:sub>A<\/jats:sub> receptors are heteropentamers that are heterogeneously distributed at different synapses in the central nervous system. Although the modulation of GABA<jats:sub>A<\/jats:sub> receptors received much attention in hippocampal pyramidal cells, information is scarce regarding the pharmacology of these receptors in inhibitory interneurons. We investigated the pharmacological properties of GABA<jats:sub>A<\/jats:sub>\u2010mediated miniature inhibitory postsynaptic currents (mIPSCs) using whole\u2010cell voltage clamp recordings in two morphologically identified types of hippocampal CA1 interneurons, horizontal and vertical cells of stratum oriens\u2010alveus. The negative modulators zinc (200 \u03bcM) and furosemide (600 \u03bcM) significantly decreased the amplitude of mIPSCs. Benzodiazepine agonists also produced significant effects: 10 \u03bcM zolpidem increased the amplitude, rise time, and decay time constant (decay \u03c4) of mIPSCs, whereas 10 \u03bcM flunitrazepam affected similarly the amplitude and decay \u03c4, but not the rise time. The neurosteroid allopregnanolone (10 \u03bcM) prolonged the decay \u03c4 of mIPSCs. Since these modulators act on different GABA<jats:sub>A<\/jats:sub> receptor subunits, this pharmacological profile suggests that GABA<jats:sub>A<\/jats:sub> receptors at spontaneously active inhibitory synapses onto vertical and horizontal interneurons are heterogeneous and formed by co\u2010assembly of different combinations of subunits (\u03b1<jats:sub>1\u20135<\/jats:sub>\u03b2<jats:sub>1\u20133<\/jats:sub>\u03b3<jats:sub>1\u20133<\/jats:sub>). Furthermore, these synaptic GABA<jats:sub>A<\/jats:sub> receptors appear in large part pharmacologically similar to those of pyramidal cells. Synapse 41:29\u201339, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.1057","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:08:54Z","timestamp":1030313334000},"page":"29-39","source":"Crossref","is-referenced-by-count":11,"title":["Sensitivity of synaptic GABA<sub>A<\/sub> receptors to allosteric modulators in hippocampal oriens\u2010alveus 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